π-Complexes with planar chirality: control centres for stereoselective synthesis

Organom etallic π-complexes are defined as the synthetic equivalents of cationic synthons for use in organic synthesis. W hen complexes of this type are employed, activation and stereocontrol effects (which arise from properties of the metal), and regiocontrol effects and functional group locations (resulting from substitution pattern), are separated from one another. The consequences of this distinction for synthesis design are discussed by using two examples, an approach for the synthesis of tridachiapyrones based on a ‘linear’ synthetic sequence, and an alternative method for double alkylations employing an ‘iterative’ strategy. Access to resolved compounds for enantiom er synthesis is described.

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