Reproducing kernel Hilbert spaces for spike train analysis

This paper introduces a generalized cross-correlation (GCC) measure for spike train analysis derived from reproducing kernel Hilbert spaces (RKHS) theory. An estimator for GCC is derived that does not depend on binning or a specific kernel and it operates directly and efficiently on spike times. For instantaneous analysis as required for real-time use, an instantaneous estimator is proposed and proved to yield the GCC on average. We finalize with two experiments illustrating the usefulness of the techniques derived.

[1]  N. Aronszajn Theory of Reproducing Kernels. , 1950 .

[2]  R. Kass,et al.  Statistical smoothing of neuronal data. , 2003, Network.

[3]  Deniz Erdogmus,et al.  Information Theoretic Learning , 2005, Encyclopedia of Artificial Intelligence.

[4]  A. Aertsen,et al.  Representation of cooperative firing activity among simultaneously recorded neurons. , 1985, Journal of neurophysiology.

[5]  G. P. Moore,et al.  Neuronal spike trains and stochastic point processes. II. Simultaneous spike trains. , 1967, Biophysical journal.

[6]  D. Perkel,et al.  Cooperative firing activity in simultaneously recorded populations of neurons: detection and measurement , 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[7]  Stefan Rotter,et al.  Higher-Order Statistics of Input Ensembles and the Response of Simple Model Neurons , 2003, Neural Computation.

[8]  Carlos D. Brody,et al.  Correlations Without Synchrony , 1999, Neural Computation.

[9]  S. Strogatz,et al.  Synchronization of pulse-coupled biological oscillators , 1990 .

[10]  José C. Príncipe,et al.  An efficient algorithm for continuous time cross correlogram of spike trains , 2008, Journal of Neuroscience Methods.

[11]  R. Kass,et al.  Multiple neural spike train data analysis: state-of-the-art and future challenges , 2004, Nature Neuroscience.

[12]  Rolf-Dieter Reiss,et al.  A Course on Point Processes , 1992 .

[13]  Peter Dayan,et al.  Theoretical Neuroscience: Computational and Mathematical Modeling of Neural Systems , 2001 .