Epoxygenase Pathways of Arachidonic Acid Metabolism*

[1]  J. Ballesteros,et al.  Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors. , 2001, Molecular pharmacology.

[2]  K. Node,et al.  Activation of Gαs Mediates Induction of Tissue-type Plasminogen Activator Gene Transcription by Epoxyeicosatrienoic Acids* , 2001, The Journal of Biological Chemistry.

[3]  D. Thompson,et al.  Pathways of Epoxyeicosatrienoic Acid Metabolism in Endothelial Cells , 2001, The Journal of Biological Chemistry.

[4]  J. Mcgiff,et al.  20-Hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids and blood pressure , 2001, Current opinion in nephrology and hypertension.

[5]  F. Gonzalez,et al.  Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation. , 2001, Pharmacogenetics.

[6]  A. A. Spector,et al.  Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. , 2001, Biochemistry.

[7]  P. Smith,et al.  Noninvasive measurement of hydrogen and potassium ion flux from single cells and epithelial structures. , 2001, American journal of physiology. Cell physiology.

[8]  F. Gonzalez,et al.  Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation* , 2000, The Journal of Biological Chemistry.

[9]  B D Hammock,et al.  Soluble Epoxide Hydrolase Regulates Hydrolysis of Vasoactive Epoxyeicosatrienoic Acids , 2000, Circulation research.

[10]  R. Roman,et al.  Renal And Cardiovascular Actions Of 20‐Hydroxyeicosatetraenoic Acid And Epoxyeicosatrienoic Acids , 2000, Clinical and experimental pharmacology & physiology.

[11]  C. Thompson,et al.  Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid. , 2000, The Journal of pharmacology and experimental therapeutics.

[12]  Jian-Kang Chen,et al.  Overexpression of C-terminal Src Kinase Blocks 14,15-Epoxyeicosatrienoic Acid-induced Tyrosine Phosphorylation and Mitogenesis* , 2000, The Journal of Biological Chemistry.

[13]  D. Kroetz,et al.  Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney. , 2000, Molecular pharmacology.

[14]  J. Mcgiff,et al.  Is EDHF an epoxyeicosatrienoic acid? , 2000, Trends in pharmacological sciences.

[15]  Zeldin,et al.  Reply: cytochrome P450-derived eicosanoids and the vascular wall. , 2000, Trends in pharmacological sciences.

[16]  W. Campbell.  New role for epoxyeicosatrienoic acids as anti-inflammatory mediators. , 2000, Trends in pharmacological sciences.

[17]  J. Falck,et al.  Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. , 2000, Journal of lipid research.

[18]  S. Karchner,et al.  Identification, Functional Characterization, and Regulation of a New Cytochrome P450 Subfamily, the CYP2Ns* , 2000, The Journal of Biological Chemistry.

[19]  D. Fulton,et al.  Renal cytochrome P450 omega-hydroxylase and epoxygenase activity are differentially modified by nitric oxide and sodium chloride. , 1999, The Journal of clinical investigation.

[20]  R. Busse,et al.  Cytochrome P450 2C is an EDHF synthase in coronary arteries , 1999, Nature.

[21]  V. Holla,et al.  The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading. , 1999, The Journal of clinical investigation.

[22]  K. Ley,et al.  Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. , 1999, Science.

[23]  A. Brash.  Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate* , 1999, The Journal of Biological Chemistry.

[24]  W. Campbell,et al.  11,12-Epoxyeicosatrienoic acid stimulates endogenous mono-ADP-ribosylation in bovine coronary arterial smooth muscle. , 1999, Circulation research.

[25]  T. Lu,et al.  Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes , 1999, The Journal of physiology.

[26]  K. Tomer,et al.  Molecular Cloning, Enzymatic Characterization, Developmental Expression, and Cellular Localization of a Mouse Cytochrome P450 Highly Expressed in Kidney* , 1999, The Journal of Biological Chemistry.

[27]  D. Zeldin,et al.  Inhibition of cardiac L-type calcium channels by epoxyeicosatrienoic acids. , 1999, Molecular pharmacology.

[28]  S. Hoffman,et al.  Calcium Influx Factor, Further Evidence It Is 5,6-Epoxyeicosatrienoic Acid* , 1999, The Journal of Biological Chemistry.

[29]  N. Weintraub,et al.  Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. , 1998, Circulation research.

[30]  Jian-Kang Chen,et al.  Epoxyeicosatrienoic Acids and Their Sulfonimide Derivatives Stimulate Tyrosine Phosphorylation and Induce Mitogenesis in Renal Epithelial Cells* , 1998, The Journal of Biological Chemistry.

[31]  D. Zeldin,et al.  Nutritional status modulates rat liver cytochrome P450 arachidonic acid metabolism. , 1998, Molecular pharmacology.

[32]  D. Zeldin,et al.  Epoxygenase metabolites of arachidonic acid affect electrophysiologic properties of rat tracheal epithelial cells1. , 1998, The Journal of pharmacology and experimental therapeutics.

[33]  N. Dulin,et al.  Phospholipase A2-mediated activation of mitogen-activated protein kinase by angiotensin II. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[34]  J. Stegeman,et al.  Arachidonic acid metabolism in the marine fish Stenotomus chrysops (Scup) and the effects of cytochrome P450 1A inducers. , 1998, Archives of biochemistry and biophysics.

[35]  L. Huang,et al.  Cytochrome P450: a novel system modulating Ca2+ channels and contraction in mammalian heart cells , 1998, The Journal of physiology.

[36]  J. T. Sanderson,et al.  2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces hepatic cytochrome P450-dependent arachidonic acid epoxygenation in diverse avian orders: regioisomer selectivity and immunochemical comparison of the TCDD-induced P450s to CYP1A4 and 1A5. , 1998, Toxicology and applied pharmacology.

[37]  M. Waterman,et al.  A Keratinocyte-specific Epoxygenase, CYP2B12, Metabolizes Arachidonic Acid with Unusual Selectivity, Producing a Single Major Epoxyeicosatrienoic Acid* , 1998, The Journal of Biological Chemistry.

[38]  W. Graier,et al.  11,12-Epoxyeicosatrienoic acid stimulates tyrosine kinase activity in porcine aortic endothelial cells. , 1998, European journal of pharmacology.

[39]  K. Tomer,et al.  Molecular Cloning, Expression, and Functional Significance of a Cytochrome P450 Highly Expressed in Rat Heart Myocytes* , 1997, The Journal of Biological Chemistry.

[40]  William L. Smith,et al.  Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2* , 1996, The Journal of Biological Chemistry.

[41]  J. Falck,et al.  Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[42]  A. A. Spector,et al.  Functional implications of a newly characterized pathway of 11,12-epoxyeicosatrienoic acid metabolism in arterial smooth muscle. , 1996, Circulation research.

[43]  B. Borhan,et al.  Novel metabolic pathways for linoleic and arachidonic acid metabolism. , 1996, Biochimica et biophysica acta.

[44]  K. Tomer,et al.  Biochemical characterization of the human liver cytochrome P450 arachidonic acid epoxygenase pathway. , 1996, Archives of biochemistry and biophysics.

[45]  P. Pratt,et al.  Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. , 1996, Circulation research.

[46]  K. Tomer,et al.  Molecular Cloning and Expression of CYP2J2, a Human Cytochrome P450 Arachidonic Acid Epoxygenase Highly Expressed in Heart (*) , 1996, The Journal of Biological Chemistry.

[47]  D. Zeldin,et al.  Eicosanoid Metabolism and Bioactivation by Microsomal Cytochrome P450 , 1996 .

[48]  J. Capdevila,et al.  Role of cytochrome P-450 epoxygenase metabolites in EGF signaling in renal proximal tubule. , 1995, The American journal of physiology.

[49]  R. DuBois,et al.  Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. , 1995, Archives of biochemistry and biophysics.

[50]  D. Waxman,et al.  Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes. , 1995, Archives of biochemistry and biophysics.

[51]  R. Miller,et al.  The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance. , 1995, The Journal of clinical investigation.

[52]  R. Roman,et al.  Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. , 1995, Journal of Vascular Research.

[53]  D. Zeldin,et al.  Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. , 1995, Archives of biochemistry and biophysics.

[54]  D. Koop,et al.  Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9. , 1994, The Journal of pharmacology and experimental therapeutics.

[55]  H. Jacobson,et al.  Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. , 1994, The Journal of clinical investigation.

[56]  E. Oliw.  Oxygenation of polyunsaturated fatty acids by cytochrome P450 monooxygenases. , 1994, Progress in lipid research.

[57]  J. Falck,et al.  Renal vasodilator activity of 5,6-epoxyeicosatrienoic acid depends upon conversion by cyclooxygenase and release of prostaglandins. , 1993, The Journal of biological chemistry.

[58]  D. Zeldin,et al.  Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase. , 1993, The Journal of biological chemistry.

[59]  C. Prakash,et al.  Cyclooxygenase-derived metabolites of 8,9-epoxyeicosatrienoic acid are potent mitogens for cultured rat glomerular mesangial cells. , 1993, Biochemical and biophysical research communications.

[60]  A. Katz,et al.  Intracellular signaling in the regulation of renal Na-K-ATPase. II. Role of eicosanoids. , 1993, The Journal of clinical investigation.

[61]  H. Jacobson,et al.  Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading. , 1992, The Journal of biological chemistry.

[62]  D. Koop,et al.  P-450-dependent arachidonic acid metabolism in rabbit olfactory microsomes. , 1992, The Journal of pharmacology and experimental therapeutics.

[63]  C. Prakash,et al.  Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenase. , 1992, Biochemical and biophysical research communications.

[64]  J. Douglas,et al.  An epoxygenase metabolite of arachidonic acid mediates angiotensin II-induced rises in cytosolic calcium in rabbit proximal tubule epithelial cells. , 1991, The Journal of clinical investigation.

[65]  J. Falck,et al.  Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties. , 1991, The Journal of biological chemistry.

[66]  H. Jacobson,et al.  Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells , 1990, Journal of cellular physiology.

[67]  H. Jacobson,et al.  Arachidonic acid epoxygenase , 1990, FEBS letters.

[68]  D. Waxman,et al.  Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. , 1990, The Journal of biological chemistry.

[69]  H. Jacobson,et al.  Cytochrome P450 metabolites of arachidonic acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct. , 1989, The Journal of clinical investigation.

[70]  J. Falck,et al.  Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase. , 1989, The Journal of biological chemistry.

[71]  J. Falck,et al.  NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols. , 1988, Archives of biochemistry and biophysics.

[72]  N. Abraham,et al.  Renal cytochrome P-450-dependent metabolism of arachidonic acid in spontaneously hypertensive rats. , 1988, Biochemical pharmacology.

[73]  V. Kishore,et al.  A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs). , 1987, Biochemical and biophysical research communications.

[74]  J. Cashman,et al.  Epoxy derivatives of arachidonic acid are potent stimulators of prolactin secretion. , 1987, Neuroendocrinology.

[75]  K. Proctor,et al.  Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase. , 1987, Circulation research.

[76]  R. Estabrook,et al.  Novel glutathione conjugates formed from epoxyeicosatrienoic acids (EETs). , 1985, Archives of biochemistry and biophysics.

[77]  J. Falck,et al.  Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets. , 1983, Biochemical and biophysical research communications.

[78]  R. Estabrook,et al.  The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase. , 1983, Archives of biochemistry and biophysics.