Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site

BackgroundThe protein encoded by the gene ybgI was chosen as a target for a structural genomics project emphasizing the relation of protein structure to function.ResultsThe structure of the ybgI protein is a toroid composed of six polypeptide chains forming a trimer of dimers. Each polypeptide chain binds two metal ions on the inside of the toroid.ConclusionThe toroidal structure is comparable to that of some proteins that are involved in DNA metabolism. The di-nuclear metal site could imply that the specific function of this protein is as a hydrolase-oxidase enzyme.

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