Demonstration of Epstein-Barr virus in carcinomas of various sites.

EBV is an etiological agent in infectious mononucleosis, is implicated in some malignant lymphomas and lymphoepithelioma-like carcinomas, and has been sporadically reported in carcinomas of the breast, lung, and other sites. We studied immunohistochemically benign and malignant tumors of the breast, lung, colon, and prostate and found EBV in some carcinomas of those sites. Also, EBV reactions were noted in hyperplasias and dysplasias, e.g., breast carcinomas in situ and prostatic intraepithelial neoplasia. Benign tumor counterparts were negative. PCR analysis of selected cases confirmed the presence of EBV. Our results suggest that EBV is not restricted to lymphoepithelioma-like carcinomas but may play an oncogenic role in frequent epithelial cancers and possibly also in hyperplasias and certain dysplasias preceding carcinomas.

[1]  C. Langston,et al.  Epstein-Barr virus-associated smooth muscle tumors in ataxia-telangiectasia: a case report and review. , 2002, Human pathology.

[2]  M. Ostrowski,et al.  Relationship between Epstein-Barr virus and lymphoepithelioma-like carcinoma of the lung: a clinicopathologic study of 6 cases and review of the literature. , 2001, Human pathology.

[3]  Kathryn Flynn,et al.  Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma. , 1995, The New England journal of medicine.

[4]  W. Henle,et al.  Infectious Mononucleosis: Clinical Manifestations in Relation to EB Virus Antibodies , 1968 .

[5]  K. Takada.  Epstein-Barr virus and gastric carcinoma , 2000, Molecular pathology : MP.

[6]  S. Leung,et al.  In situ detection of Epstein–Barr virus in non‐small cell lung carcinomas , 1995, The Journal of pathology.

[7]  S. Glaser,et al.  Absence of Epstein‐Barr virus EBER‐1 transcripts in an epidemiologically diverse group of breast cancers , 1998, International journal of cancer.

[8]  E. Kieff.  Epstein-Barr virus--increasing evidence of a link to carcinoma. , 1995, The New England journal of medicine.

[9]  Nasopharyngeal carcinoma in childhood and adolescence , 2000, Cancer.

[10]  G. Nemerow,et al.  Identification of gp350 as the viral glycoprotein mediating attachment of Epstein-Barr virus (EBV) to the EBV/C3d receptor of B cells: sequence homology of gp350 and C3 complement fragment C3d , 1987, Journal of virology.

[11]  Su-xia Lin,et al.  Lymphoepithelioma-like carcinoma of the lung with a better prognosis. A clinicopathologic study of 32 cases. , 2001, American journal of clinical pathology.

[12]  P. Chu,et al.  No significant association of Epstein-Barr virus infection with invasive breast carcinoma. , 2001, The American journal of pathology.

[13]  N. Toumi,et al.  Nasopharyngeal carcinoma in childhood and adolescence: analysis of a series of 32 patients treated with combined chemotherapy and radiotherapy. , 2003, European journal of cancer.

[14]  E. Kremmer,et al.  Detection of Epstein-Barr virus in invasive breast cancers. , 1999, Journal of the National Cancer Institute.

[15]  A. Orucevic,et al.  A novel, nuclear pore-associated, widely distributed molecule overexpressed in oncogenesis and development. , 2000, The American journal of pathology.

[16]  S. Akiba,et al.  Epstein‐Barr Virus‐associated Gastric Carcinoma in Japanese Brazilians and Non‐Japanese Brazilians in São Paulo , 2001, Japanese journal of cancer research : Gann.

[17]  F. Spyratos,et al.  Frequency and genome load of Epstein-Barr virus in 509 breast cancers from different geographical areas , 2001, British Journal of Cancer.

[18]  J. Menárguez,et al.  Presence of Epstein-Barr virus and strain type assignment in Argentine childhood Hodgkin's disease. , 1995, Blood.

[19]  B E Griffin,et al.  Epstein-Barr virus in epithelial cell tumors: a breast cancer study. , 1995, Cancer research.

[20]  M. Epstein,et al.  VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. , 1964, Lancet.

[21]  D. Crawford,et al.  Biology and disease associations of Epstein-Barr virus. , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.