Analysis Between Kidney Function and Hearing Loss Using Hemodynamic and Physical Characteristics: A Large Cross-Sectional Cohort Study With Health Screening Test

Background and Objectives A large-scale community-based study of the general population has not been conducted. There have been no studies on the relationship between decreased renal function and the degree of hearing loss. Thus, the purpose was to evaluate the relationship between hearing loss and impaired renal function with a large number of populations.Subjects and Method We performed a cross-sectional population-based cohort study by enrolling 470718 adults, 18 to 80 years old with pure tone audiometry tests who had regular health screening between 2013 and 2018. Hearing loss was defined as a pure-tone average of thresholds at 500, 1000, and 2000 Hz in both right and left ears. Kidney function was evaluated based on eGFR. Chronic kidney disease (CKD) was diagnosed as an eGFR<60 mL/ min/1.73 m². Other predictor variables including noise and age that can affect hearing were also used to evaluate correlation factors.Results Of Participants with CKD, 14.2% had any hearing loss (>25 dB) and 5.0% had above moderate hearing loss (>40 dB). But those with normal kidney function, 2.0% either had any hearing loss and 0.4% had above moderate hearing loss. The odds ratio (OR) of above moderate hearing loss for participants with CKD was 1.51 (95% confidence interval [CI]: 1.15-2.00, p=0.003) but the OR of mild hearing loss for participants with CKD was 0.82 (95% CI: 0.67- 1.02, p=0.073). The result suggested that CKD and above moderate hearing loss were related even after correcting for potential confounders, but had no statistical significance with mild hearing loss.Conclusion Decreased kidney function is associated with above moderate hearing loss.

[1]  Yafeng Wang,et al.  The association between reduced kidney function and hearing loss: a cross-sectional study , 2020, BMC Nephrology.

[2]  Christine A. White,et al.  CKD: A Call for an Age-Adapted Definition. , 2019, Journal of the American Society of Nephrology : JASN.

[3]  A. Nowakowski,et al.  Association between hearing organ and renal function in young adult type 1 diabetic patients: A cross-sectional study , 2018, Scientific Reports.

[4]  Dong-Joon Park,et al.  Association of hearing impairment with chronic kidney disease: a cross-sectional study of the Korean general population , 2015, BMC Nephrology.

[5]  R. Kandasamy,et al.  Prevalence and patterns of hearing loss among chronic kidney disease patients undergoing haemodialysis. , 2015, The Australasian medical journal.

[6]  S. Govender,et al.  Cochlear function in patients with chronic kidney disease. , 2013, The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings.

[7]  Roopesh Tiwari,et al.  A study on hearing evaluation in patients of chronic renal failure , 2011 .

[8]  K. Kim Systemic diseases and hearing loss , 2011 .

[9]  P. Mitchell,et al.  The association between reduced GFR and hearing loss: a cross-sectional population-based study. , 2010, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[10]  Chih-Cheng Hsu,et al.  Are Asians at greater mortality risks for being overweight than Caucasians? Redefining obesity for Asians , 2009, Public Health Nutrition.

[11]  E. Platz,et al.  Prevalence of hearing loss and differences by demographic characteristics among US adults: data from the National Health and Nutrition Examination Survey, 1999-2004. , 2008, Archives of internal medicine.

[12]  M. Knipper,et al.  Functional significance of channels and transporters expressed in the inner ear and kidney. , 2007, American journal of physiology. Cell physiology.

[13]  C. Thodi,et al.  Hearing in renal failure. , 2006, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[14]  D. Zwolińska,et al.  [The influence of haemodialysis on hearing organ of children with chronic renal failure]. , 2002, Otolaryngologia polska = The Polish otolaryngology.

[15]  J H Dennis,et al.  High-frequency (10-18 kHz) hearing thresholds: reliability, and effects of age and occupational noise exposure. , 2001, Occupational medicine.

[16]  A. Levey,et al.  A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation , 1999, Annals of Internal Medicine.

[17]  S. Lam,et al.  The Effect of Hemodialysis on Hearing Using Pure-Tone Audiometry and Distortion-Product Otoacoustic Emissions , 1998, ORL.

[18]  G. Pelliccioni,et al.  [Utility of electrophysiologic study using the blink reflex and brainstem evoked potentials for the evaluation of the course of uremic polyneuropathy]. , 1995, Minerva urologica e nefrologica = The Italian journal of urology and nephrology.

[19]  B. Tucker,et al.  Hearing Loss in Chronic Renal Failure-Hearing Threshold Changes following Haemodialysis , 1991, Journal of the Royal Society of Medicine.

[20]  R. Maiorca,et al.  Audiological findings in elderly patients with chronic renal failure. , 1990, Acta oto-laryngologica. Supplementum.

[21]  U. Gafter,et al.  Brainstem auditory evoked responses in chronic renal failure and the effect of hemodialysis. , 1989, Nephron.

[22]  A. Albertazzi,et al.  The natural history of uremic neuropathy. , 1988, Contributions to nephrology.

[23]  A. Albertazzi,et al.  Electrophysiological aspects of nervous conduction in uremia. , 1988, Clinical nephrology.

[24]  W. Arnold Inner Ear and Renal Diseases , 1984, The Annals of otology, rhinology & laryngology. Supplement.

[25]  James C. Hutchinson,et al.  Electrophysiologic analysis of auditory, vestibular and brain stem function in chronic renal failure , 1982, The Laryngoscope.

[26]  C. Quick,et al.  The relationship between cochlea and kidney , 1973, The Laryngoscope.

[27]  A. Yassin,et al.  The relationship between electrolyte balance and cochlear disturbances in cases of renal failure , 1970, The Journal of Laryngology & Otology.