Squamous Cell Carcinoma of the Caruncle.

Squamous cell carcinoma (SCC) of the lacrimal caruncle is a rare entity. The authors report the management and outcomes of 3 cases of caruncle SCC. Case 1 underwent wide margin surgical excision with adjuvant topical chemotherapy for a poorly differentiated SCC. He later developed regional lymph node metastasis and required modified radical neck dissection. Case 2 underwent wide margin surgical excision with cryotherapy and adjuvant topical chemotherapy for an invasive moderately differentiated SCC. She later developed a recurrence and underwent orbital exenteration. Case 3 was a moderately differentiated SCC treated with wide margin excision alone and had no recurrence during 5-year follow up. Careful surveillance of caruncle SCC is required, given the observed propensity for local recurrence and/or regional metastasis.

[1]  Sander R. Dubovy,et al.  Predictors of ocular surface squamous neoplasia recurrence after excisional surgery. , 2012, Ophthalmology.

[2]  J. Harvey,et al.  Lymphatic Drainage Patterns of the Human Eyelid: Assessed by Lymphoscintigraphy , 2010, Ophthalmic plastic and reconstructive surgery.

[3]  S. Uffer,et al.  Tumors of the caruncle: a clinicopathologic correlation. , 2006, American journal of ophthalmology.

[4]  C. Shields,et al.  Tumors of the conjunctiva and cornea. , 2004, Survey of ophthalmology.

[5]  S. Onal,et al.  Excision and cryosurgery in the treatment of conjunctival malignant epithelial tumours , 2003, Eye.

[6]  P. Van Dessel,et al.  Invasive squamous cell carcinoma of the conjunctiva. , 2000, Bulletin de la Societe belge d'ophtalmologie.

[7]  D. Char,et al.  Intraepithelial and invasive squamous cell carcinoma of the conjunctiva: analysis of 60 cases , 1999, The British journal of ophthalmology.

[8]  J. Crompton,et al.  Perineural spread of cutaneous squamous cell carcinoma via the orbit. Clinical features and outcome in 21 cases. , 1997, Ophthalmology.

[9]  V. Elner,et al.  Mucoepidermoid carcinoma of the caruncle. , 1997, American journal of ophthalmology-glaucoma.

[10]  J. Flanagan,et al.  Squamous Cell Carcinoma of the Eyelid , 1994, Ophthalmic plastic and reconstructive surgery.

[11]  W. Green,et al.  Squamous cell carcinoma of the eyelids. , 1987, Ophthalmology.

[12]  H. Atta,et al.  Adenosquamous carcinoma of the lacrimal caruncle: a case report. , 1986, The British journal of ophthalmology.

[13]  W. Green,et al.  Lesions of the caruncle: a clinicohistopathologic study. , 1978, Survey of ophthalmology.

[14]  J. Shulman Treatment of malignant tumours of the eyelids by plastic surgery. , 1962, British journal of plastic surgery.