论文信息 - Pharmaceutical heterogeneous system. IV. A kinetic approach to the stability screening of solid dosage forms containing aspirin.

Pharmaceutical heterogeneous system. IV. A kinetic approach to the stability screening of solid dosage forms containing aspirin.

The effect of common tablet excipients and physiologically active materials on the hydrolysis of aspirin in aqueous suspension has been studied. The relationship of hydrolytic rate to solvent concentration in these systems has been determined. The results obtained have been utilized in the stability ranking for various tablet mixes. The kinetic ranking is compared to the relative stability of tablets and powders. An attempt is made to correlate extrapolated kinetic data with stability results for the tablets.

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