DMD #12138 DIFFERENTIAL REGULATION OF HEPATIC TRANSPORTERS IN THE ABSENCE OF TNF-α, IL-1β, IL-6 AND NF-κB IN TWO MODELS OF CHOLESTASIS

Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721 (A.J.L., N.J.C.); Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island Kingston, RI 02881 (A.L.S.); 2nd Department of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (M. Ç .A.); Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093 (M.K.). DMD Fast Forward. Published on December 6, 2006 as doi:10.1124/dmd.106.012138

[1]  Curtis D. Klaassen,et al.  INDUCTION OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN FAMILY OF TRANSPORTERS BY CHEMICAL ACTIVATORS OF RECEPTOR-MEDIATED PATHWAYS IN MOUSE LIVER , 2005, Drug Metabolism and Disposition.

[2]  Xingguo Cheng,et al.  TISSUE DISTRIBUTION AND ONTOGENY OF MOUSE ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPS) , 2005, Drug Metabolism and Disposition.

[3]  F. Lammert,et al.  Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver. , 2005, American journal of physiology. Gastrointestinal and liver physiology.

[4]  C. Klaassen,et al.  Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[5]  S. Choudhuri,et al.  Down-regulation of mouse organic anion-transporting polypeptide 4 (Oatp4; Oatp1b2; Slc21a10) mRNA by lipopolysaccharide through the toll-like receptor 4 (TLR4). , 2004, Drug metabolism and disposition: the biological fate of chemicals.

[6]  Ning Li,et al.  Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. , 2004, Drug metabolism and disposition: the biological fate of chemicals.

[7]  C. Klaassen,et al.  Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels. , 2004, Drug metabolism and disposition: the biological fate of chemicals.

[8]  J. Boyer,et al.  Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. , 2004, Journal of hepatology.

[9]  C. Gartung,et al.  Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis , 2003, Hepatology.

[10]  M. Karin,et al.  IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. , 2003, Immunity.

[11]  P. Marcellin,et al.  Role of cytokines in the assessment of the severity of chronic hepatitis C and the prediction of response to therapy. , 2002, Romanian journal of gastroenterology.

[12]  R. Beyaert,et al.  Crosstalk between NF-kappaB-activating and apoptosis-inducing proteins of the TNF-receptor complex. , 2001, Molecular cell biology research communications : MCBRC.

[13]  C. Deutschman,et al.  Intraabdominal sepsis down-regulates transcription of sodium taurocholate cotransporter and multidrug resistance-associated protein in rats. , 2000, Shock.

[14]  Roger A. Davis,et al.  Bile Acid Induction of Cytokine Expression by Macrophages Correlates with Repression of Hepatic Cholesterol 7α-Hydroxylase* , 2000, The Journal of Biological Chemistry.

[15]  P. Bosma,et al.  Zonal down‐regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver , 2000, Hepatology.

[16]  Y. Sugiyama,et al.  Characterization of inducible nature of MRP3 in rat liver. , 2000, American journal of physiology. Gastrointestinal and liver physiology.

[17]  G. Hooiveld,et al.  Up‐regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down‐regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver , 1998, Hepatology.

[18]  J. Boyer,et al.  Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. , 1998, The Journal of clinical investigation.

[19]  M. Karin,et al.  Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. , 1997, The New England journal of medicine.

[20]  D. Beier,et al.  Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. , 1996, Gastroenterology.

[21]  J. O'donohue,et al.  Immunological control in primary biliary cirrhosis: the cytokine story , 1996, Clinical and experimental immunology.

[22]  P. Jansen,et al.  Impaired hepatocanalicular organic anion transport in endotoxemic rats. , 1995, The American journal of physiology.

[23]  D. Kershenobich,et al.  [Cytokines and the liver]. , 1990, Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion.

[24]  G. Alexander,et al.  Increased plasma tumor necrosis factor in severe alcoholic hepatitis. , 1990, Annals of internal medicine.