Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.

Franz Matschinsky, * Yin Liang, * Prabakaran Kesavan, * Liqun Wang, * Philippe Froguel,t Gilberto Velho,t Daniel Cohen,t M. Alan Permutt,I Yukio Tanizawa,1 Thomas L. Jetton,11 Kevin Niswender,11 and Mark A. Magnuson,, *Department of Biochemistry and Biophysics, and the Diabetes Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104; tCentre d'Etude du Polymorphisme Humain, 75010 Paris, France; Metabolism Division, Washington University School of Medicine, St. Louis, Missouri 63110; and IlDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232

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