Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3–dependent sensitization

Supplemental Digital Content is Available in the Text. Inhibiting osteoclast activity and acid-sensing ion channel 3 signaling prevents the development of autoantibody-mediated mechanical hypersensitivity, and increased lysophosphatidylcholine 16:0 and secretory phospholipase A2 contribute to sensitization in this model.