Using Gene Expression Signatures to Dissect Insulin Resistance Subtypes

It is now apparent that many diseases such as diabetes are more complex and heterogeneous than had been thought just a decade ago. Combinations of varying causative factors, as well as interactions between environmental and genetic factors all play a role in the onset of the disease. This complexity has hindered the development of new effective treatment options for patients, and makes understanding the onset of the disease difficult. This chapter will focus on a new technology to study diabetes using a novel unbiased approach, and to develop individualised therapeutics for patients with diabetes.

[1]  S. Brophy,et al.  Interventions for latent autoimmune diabetes (LADA) in adults. , 2011, The Cochrane database of systematic reviews.

[2]  P. Meikle,et al.  Lipidomics is providing new insight into the metabolic syndrome and its sequelae , 2011, Current opinion in lipidology.

[3]  Guoqing Wang,et al.  Gene-Expression Signatures Can Distinguish Gastric Cancer Grades and Stages , 2011, PloS one.

[4]  Axel Benner,et al.  A radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced adverse side effects. , 2011, Cancer letters.

[5]  David E James,et al.  A gene expression signature for insulin resistance. , 2011, Physiological genomics.

[6]  M. Langeveld,et al.  Glycosphingolipids and insulin resistance. , 2011, Advances in experimental medicine and biology.

[7]  Jens K. Habermann,et al.  A 12-Gene Genomic Instability Signature Predicts Clinical Outcomes in Multiple Cancer Types , 2010, The International journal of biological markers.

[8]  S. Nissen,et al.  Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. , 2010, Archives of internal medicine.

[9]  T. Lutz,et al.  Brainstem mechanisms of amylin-induced anorexia , 2010, Physiology & Behavior.

[10]  W. Huber,et al.  Microarray data quality control improves the detection of differentially expressed genes. , 2010, Genomics.

[11]  A. Klip,et al.  Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells , 2009, Archives of physiology and biochemistry.

[12]  M. Mann,et al.  The Phosphotyrosine Interactome of the Insulin Receptor Family and Its Substrates IRS-1 and IRS-2*S , 2009, Molecular & Cellular Proteomics.

[13]  B. Zinman,et al.  Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy , 2009, Diabetes Care.

[14]  Zhen Jiang,et al.  Gene set enrichment analysis using linear models and diagnostics , 2008, Bioinform..

[15]  Trevor Hastie,et al.  Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification. , 2008, European journal of cancer.

[16]  L. Almasy,et al.  Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes , 2007, Nature Genetics.

[17]  Jae K. Lee,et al.  A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery , 2007, Proceedings of the National Academy of Sciences.

[18]  Eric Vaillancourt,et al.  Coordinated Regulation of Nutrient and Inflammatory Responses by STAMP2 Is Essential for Metabolic Homeostasis , 2007, Cell.

[19]  Todd R Golub,et al.  Signature-Based Small Molecule Screening Identifies Cytosine Arabinoside as an EWS/FLI Modulator in Ewing Sarcoma , 2007, PLoS medicine.

[20]  E. Horton,et al.  Progress in the treatment of type 2 diabetes: new pharmacologic approaches to improve glycemic control , 2007, Current medical research and opinion.

[21]  P. Cryer.  Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A Consensus Statement From the American Diabetes Association and the European Association for the Study of Diabetes , 2007, Diabetes Care.

[22]  A. Janež,et al.  Molecular mechanisms of insulin resistance and associated diseases. , 2007, Clinica chimica acta; international journal of clinical chemistry.

[23]  N. Kaji,et al.  Genome wide expression analysis of white blood cells and liver of pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats using a cDNA microarray. , 2006, Biological & pharmaceutical bulletin.

[24]  Manikandan Jayapal,et al.  DNA MICROARRAY TECHNOLOGY FOR TARGET IDENTIFICATION AND VALIDATION , 2006, Clinical and experimental pharmacology & physiology.

[25]  Arya M. Sharma.  The obese patient with diabetes mellitus: from research targets to treatment options. , 2006, The American journal of medicine.

[26]  E. Lander,et al.  Reactive oxygen species have a causal role in multiple forms of insulin resistance , 2006, Nature.

[27]  M. Vázquez-Carrera,et al.  Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation. , 2006, Endocrinology.

[28]  M. Vázquez-Carrera,et al.  Palmitate Induces Tumor Necrosis Factor-α Expression in C2C12 Skeletal Muscle Cells by a Mechanism Involving Protein Kinase C and Nuclear Factor-κB Activation , 2006 .

[29]  D. Drucker.  Biologic actions and therapeutic potential of the proglucagon-derived peptides , 2005, Nature Clinical Practice Endocrinology &Metabolism.

[30]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Dennis D. Kim,et al.  Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. , 2005, Diabetes care.

[32]  Paul B Watkins,et al.  Idiosyncratic Liver Injury: Challenges and Approaches , 2005, Toxicologic pathology.

[33]  J. Rungby,et al.  Amylin agonists: a novel approach in the treatment of diabetes. , 2004, Diabetes.

[34]  R. O’Doherty,et al.  Fatty Acid-induced Insulin Resistance in L6 Myotubes Is Prevented by Inhibition of Activation and Nuclear Localization of Nuclear Factor κB* , 2004, Journal of Biological Chemistry.

[35]  Gordon K Smyth,et al.  Statistical Applications in Genetics and Molecular Biology Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2011 .

[36]  Todd R Golub,et al.  Gene expression–based high-throughput screening(GE-HTS) and application to leukemia differentiation , 2004, Nature Genetics.

[37]  R. Turner,et al.  Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.

[38]  D. Drucker.  Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis. , 2003, Endocrinology.

[39]  M. Schwartz,et al.  Genetics and pathophysiology of human obesity. , 2003, Annual review of medicine.

[40]  Scott A Summers,et al.  Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. , 2003, Archives of biochemistry and biophysics.

[41]  Harvey F Lodish,et al.  Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha. , 2003, Cytokine & growth factor reviews.

[42]  P. Raskin,et al.  Report of the expert committee on the diagnosis and classification of diabetes mellitus. , 1999, Diabetes care.

[43]  E. Salpeter,et al.  Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. , 2003, The Cochrane database of systematic reviews.

[44]  Yudong D. He,et al.  A Gene-Expression Signature as a Predictor of Survival in Breast Cancer , 2002 .

[45]  G. Cooney,et al.  AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. , 2002, Diabetes.

[46]  J. Shaw,et al.  Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention , 2002, Diabetic medicine : a journal of the British Diabetic Association.

[47]  N. Ruderman,et al.  Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α , 2002 .

[48]  Robert Atkins,et al.  The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study. , 2002, Diabetes care.

[49]  A. Baudry,et al.  Genetic manipulation of insulin signaling, action and secretion in mice , 2002, EMBO reports.

[50]  S. Fowler,et al.  Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. , 2002 .

[51]  A. Saltiel,et al.  Insulin signaling pathways in time and space. , 2002, Trends in cell biology.

[52]  Michael Karin,et al.  Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ , 2001, Science.

[53]  R. Bergman,et al.  Free Fatty Acids and Pathogenesis of Type 2 Diabetes Mellitus , 2000, Trends in Endocrinology & Metabolism.

[54]  任艳,et al.  胰岛素增敏剂一Thiazolidinediones研究现状 , 2000 .

[55]  J. Mckinlay,et al.  US public health and the 21st century: diabetes mellitus , 2000, The Lancet.

[56]  M. Davies,et al.  Impaired glucose tolerance and fasting hyperglycaemia have different characteristics , 2000, Diabetic medicine : a journal of the British Diabetic Association.

[57]  Ash A. Alizadeh,et al.  Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling , 2000, Nature.

[58]  Simeon I. Taylor,et al.  Deconstructing Type 2 Diabetes , 1999, Cell.

[59]  V. Fonseca,et al.  Insulin resistance syndrome: options for treatment. , 1999, Southern medical journal.

[60]  J. Blangero,et al.  Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans. The San Antonio Family Heart Study. , 1996, Circulation.

[61]  R. Tisch,et al.  Insulin-Dependent Diabetes Mellitus , 1996, Cell.

[62]  Ronald W. Davis,et al.  Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray , 1995, Science.

[63]  E. Ravussin,et al.  Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. , 1993, The New England journal of medicine.

[64]  L. Groop.  Sulfonylureas in NIDDM , 1992, Diabetes Care.