Genomic organization, structure, regulation and pathogenic role of pilus constituents in major pathogenic Streptococci and Enterococci.

[1]  E. Baker,et al.  Roles of Minor Pilin Subunits Spy0125 and Spy0130 in the Serotype M1 Streptococcus pyogenes Strain SF370 , 2010, Journal of bacteriology.

[2]  V. Cavallari,et al.  Immunoprotective activities of a Streptococcus suis pilus subunit in murine models of infection. , 2010, Vaccine.

[3]  I. Margarit,et al.  Typing of the pilus-protein-encoding FCT region and biofilm formation as novel parameters in epidemiological investigations of Streptococcus pyogenes isolates from various infection sites. , 2010, Journal of medical microbiology.

[4]  G. Grandi,et al.  Specific Involvement of Pilus Type 2a in Biofilm Formation in Group B Streptococcus , 2010, PloS one.

[5]  B. Murray,et al.  Bicarbonate enhances expression of the endocarditis and biofilm associated pilus locus, ebpR-ebpABC, in Enterococcus faecalis , 2010, BMC Microbiology.

[6]  T. Vernet,et al.  Structural basis of host cell recognition by the pilus adhesin from Streptococcus pneumoniae. , 2010, Structure.

[7]  T. Sekizaki,et al.  Mutations in the Gene Encoding the Ancillary Pilin Subunit of the Streptococcus suis srtF Cluster Result in Pili Formed by the Major Subunit Only , 2010, PloS one.

[8]  R. Rappuoli,et al.  Molecular architecture of Streptococcus pneumoniae TIGR4 pili , 2009, The EMBO journal.

[9]  A. D. Di Guilmi,et al.  Sortase activity is controlled by a flexible lid in the pilus biogenesis mechanism of gram-positive pathogens. , 2009, Biochemistry.

[10]  R. Lamont,et al.  Streptococcus Adherence and Colonization , 2009, Microbiology and Molecular Biology Reviews.

[11]  M. Bonten,et al.  LPxTG surface proteins of enterococci. , 2009, Trends in microbiology.

[12]  J. Musser,et al.  A decade of molecular pathogenomic analysis of group A Streptococcus. , 2009, The Journal of clinical investigation.

[13]  T. Sekizaki,et al.  Genetic organization and preferential distribution of putative pilus gene clusters in Streptococcus suis. , 2009, Veterinary microbiology.

[14]  J. Musser,et al.  Transcriptome Adaptation of Group B Streptococcus to Growth in Human Amniotic Fluid , 2009, PloS one.

[15]  E. Baker,et al.  Intramolecular Isopeptide Bonds Give Thermodynamic and Proteolytic Stability to the Major Pilin Protein of Streptococcus pyogenes* , 2009, The Journal of Biological Chemistry.

[16]  D. Thanassi,et al.  Linkage of T3 and Cpa pilins in the Streptococcus pyogenes M3 pilus , 2009, Molecular microbiology.

[17]  Carol Phillips,et al.  The ecology, epidemiology and virulence of Enterococcus. , 2009, Microbiology.

[18]  K. McIver.  Stand-alone response regulators controlling global virulence networks in streptococcus pyogenes. , 2009, Contributions to microbiology.

[19]  M. Collin,et al.  Bacterial Sensing and Signaling , 2009 .

[20]  F. Schmidt,et al.  The High Biofilm-Encoding Bee Locus: A Second Pilus Gene Cluster in Enterococcus faecalis? , 2009, Current Microbiology.

[21]  Liisa Holm,et al.  LOCP - locating pilus operons in Gram-positive bacteria , 2009, Bioinform..

[22]  S. Dramsi,et al.  Dual Role for Pilus in Adherence to Epithelial Cells and Biofilm Formation in Streptococcus agalactiae , 2009, PLoS pathogens.

[23]  Y. Auffray,et al.  Ers a Crp/Fnr-like transcriptional regulator of Enterococcus faecalis. , 2009, International journal of food microbiology.

[24]  Y. Auffray,et al.  Ers Controls Glycerol Metabolism in Enterococcus faecalis , 2009, Current Microbiology.

[25]  J. Musser,et al.  Analysis of growth-phase regulated genes in Streptococcus agalactiae by global transcript profiling , 2009, BMC Microbiology.

[26]  J. Sillanpää,et al.  Distribution of Genes Encoding MSCRAMMs and Pili in Clinical and Natural Populations of Enterococcus faecium , 2009, Journal of Clinical Microbiology.

[27]  E. Baker,et al.  Pili in Gram-negative and Gram-positive bacteria — structure, assembly and their role in disease , 2009, Cellular and Molecular Life Sciences.

[28]  J. Musser,et al.  Sequence variation in group A Streptococcus pili and association of pilus backbone types with lancefield T serotypes. , 2008, The Journal of infectious diseases.

[29]  J. Bárcena,et al.  Overcoming function annotation errors in the Gram-positive pathogen Streptococcus suis by a proteomics-driven approach , 2008, BMC Genomics.

[30]  G. Grandi,et al.  Functional Characterization of a Newly Identified Group B Streptococcus Pullulanase Eliciting Antibodies Able to Prevent Alpha-Glucans Degradation , 2008, PloS one.

[31]  B. Kreikemeyer,et al.  Mode of Expression and Functional Characterization of FCT-3 Pilus Region-Encoded Proteins in Streptococcus pyogenes Serotype M49 , 2008, Infection and Immunity.

[32]  S. Normark,et al.  Sortase-mediated assembly and surface topology of adhesive pneumococcal pili , 2008, Molecular microbiology.

[33]  Anjali Mandlik,et al.  The molecular switch that activates the cell wall anchoring step of pilus assembly in gram-positive bacteria , 2008, Proceedings of the National Academy of Sciences.

[34]  E. Muñoz-Elías,et al.  Isolation of Streptococcus pneumoniae Biofilm Mutants and Their Characterization during Nasopharyngeal Colonization , 2008, Infection and Immunity.

[35]  G. Grandi,et al.  Pilus backbone contributes to group B Streptococcus paracellular translocation through epithelial cells. , 2008, The Journal of infectious diseases.

[36]  J. Musser,et al.  Extensive Adaptive Changes Occur in the Transcriptome of Streptococcus agalactiae (Group B Streptococcus) in Response to Incubation with Human Blood , 2008, PloS one.

[37]  V. Nizet,et al.  Recent advances in understanding the molecular basis of group B Streptococcus virulence , 2008, Expert Reviews in Molecular Medicine.

[38]  P. Serror,et al.  Safety assessment of dairy microorganisms: the Enterococcus genus. , 2008, International journal of food microbiology.

[39]  A. Camilli,et al.  Roles of the Sortases of Streptococcus pneumoniae in Assembly of the RlrA Pilus , 2008, Journal of bacteriology.

[40]  Michael T. Laub,et al.  Rewiring the Specificity of Two-Component Signal Transduction Systems , 2008, Cell.

[41]  G. Grandi,et al.  Sortase A Utilizes an Ancillary Protein Anchor for Efficient Cell Wall Anchoring of Pili in Streptococcus agalactiae , 2008, Infection and Immunity.

[42]  V. Nizet,et al.  A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[43]  G. Bensi,et al.  Scavenger receptor gp340 aggregates group A streptococci by binding pili , 2008, Molecular microbiology.

[44]  C. Donati,et al.  A Second Pilus Type in Streptococcus pneumoniae Is Prevalent in Emerging Serotypes and Mediates Adhesion to Host Cells , 2008, Journal of bacteriology.

[45]  E. Tuomanen,et al.  Convergence of Regulatory Networks on the Pilus Locus of Streptococcus pneumoniae , 2008, Infection and Immunity.

[46]  Jeffrey N. Weiser,et al.  The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease , 2008, Nature Reviews Microbiology.

[47]  D. Bessen,et al.  Heterogeneity in the Polarity of Nra Regulatory Effects on Streptococcal Pilus Gene Transcription and Virulence , 2008, Infection and Immunity.

[48]  W. Hanage,et al.  Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related. , 2008, The Journal of infectious diseases.

[49]  R. Rappuoli,et al.  Pneumococcal Pili Are Composed of Protofilaments Exposing Adhesive Clusters of Rrg A , 2008, PLoS pathogens.

[50]  M. Ramirez,et al.  The presence of the pilus locus is a clonal property among pneumococcal invasive isolates , 2008, BMC Microbiology.

[51]  M. Laub,et al.  Specificity in two-component signal transduction pathways. , 2007, Annual review of genetics.

[52]  Edward N. Baker,et al.  Stabilizing Isopeptide Bonds Revealed in Gram-Positive Bacterial Pilus Structure , 2007, Science.

[53]  D. Zähner,et al.  SipA Is Required for Pilus Formation in Streptococcus pyogenes Serotype M3 , 2007, Journal of bacteriology.

[54]  R. Rappuoli,et al.  RrgA is a pilus-associated adhesin in Streptococcus pneumoniae , 2007, Molecular microbiology.

[55]  M. Glocker,et al.  The Streptococcus pyogenes Serotype M49 Nra-Ralp3 Transcriptional Regulatory Network and Its Control of Virulence Factor Expression from the Novel eno ralp3 epf sagA Pathogenicity Region , 2007, Infection and Immunity.

[56]  M. Bonten,et al.  Five Genes Encoding Surface-Exposed LPXTG Proteins Are Enriched in Hospital-Adapted Enterococcus faecium Clonal Complex 17 Isolates , 2007, Journal of bacteriology.

[57]  S. Narayana,et al.  An IgG-like domain in the minor pilin GBS52 of Streptococcus agalactiae mediates lung epithelial cell adhesion. , 2007, Structure.

[58]  B. Hirst,et al.  Pili mediate specific adhesion of Streptococcus pyogenes to human tonsil and skin , 2007, Cellular microbiology.

[59]  Kavindra V. Singh,et al.  Importance of the ebp (endocarditis- and biofilm-associated pilus) locus in the pathogenesis of Enterococcus faecalis ascending urinary tract infection. , 2007, The Journal of infectious diseases.

[60]  J. Harel,et al.  Use of Selective Capture of Transcribed Sequences To Identify Genes Preferentially Expressed by Streptococcus suis upon Interaction with Porcine Brain Microvascular Endothelial Cells , 2007, Applied and Environmental Microbiology.

[61]  J. Musser,et al.  Streptococcus pyogenes pili promote pharyngeal cell adhesion and biofilm formation , 2007, Molecular microbiology.

[62]  K. O'Brien,et al.  Association of the Pneumococcal Pilus with Certain Capsular Serotypes but Not with Increased Virulence , 2007, Journal of Clinical Microbiology.

[63]  In Ho Park,et al.  Discovery of a New Capsular Serotype (6C) within Serogroup 6 of Streptococcus pneumoniae , 2007, Journal of Clinical Microbiology.

[64]  R. Rappuoli,et al.  Streptococcus pneumoniae Pilus Subunits Protect Mice against Lethal Challenge , 2006, Infection and Immunity.

[65]  M. Bonten,et al.  Growth Condition-Dependent Esp Expression by Enterococcus faecium Affects Initial Adherence and Biofilm Formation , 2006, Infection and Immunity.

[66]  O. Kuipers,et al.  Regulation of Gene Expression in Streptococcus pneumoniae by Response Regulator 09 Is Strain Dependent , 2006, Journal of bacteriology.

[67]  V. Nizet,et al.  Group B Streptococcal Pilus Proteins Contribute to Adherence to and Invasion of Brain Microvascular Endothelial Cells , 2006, Journal of bacteriology.

[68]  D. Bessen,et al.  Population Genetics and Linkage Analysis of Loci within the FCT Region of Streptococcus pyogenes , 2006, Journal of bacteriology.

[69]  J. Sillanpää,et al.  Endocarditis and biofilm-associated pili of Enterococcus faecalis. , 2006, The Journal of clinical investigation.

[70]  D. Zähner,et al.  Pili with strong attachments: Gram‐positive bacteria do it differently , 2006, Molecular microbiology.

[71]  I. Margarit,et al.  Use of Lactococcus lactis expressing pili from group B Streptococcus as a broad-coverage vaccine against streptococcal disease. , 2006, The Journal of infectious diseases.

[72]  I. Margarit,et al.  Identification of novel genomic islands coding for antigenic pilus‐like structures in Streptococcus agalactiae , 2006, Molecular microbiology.

[73]  Rino Rappuoli,et al.  Pili in Gram-positive pathogens , 2006, Nature Reviews Microbiology.

[74]  S. Guadagnini,et al.  Assembly and role of pili in group B streptococci , 2006, Molecular microbiology.

[75]  S. Hilsenbeck,et al.  Comparison of OG1RF and an Isogenic fsrB Deletion Mutant by Transcriptional Analysis: the Fsr System of Enterococcus faecalis Is More than the Activator of Gelatinase and Serine Protease , 2006, Journal of bacteriology.

[76]  A. Camilli,et al.  RrgA and RrgB Are Components of a Multisubunit Pilus Encoded by the Streptococcus pneumoniae rlrA Pathogenicity Islet , 2006, Infection and Immunity.

[77]  R. Gross,et al.  Regulation of bacterial virulence by two-component systems. , 2006, Current opinion in microbiology.

[78]  Arto S. Baghdayan,et al.  Putative Surface Proteins Encoded within a Novel Transferable Locus Confer a High-Biofilm Phenotype to Enterococcus faecalis , 2006, Journal of bacteriology.

[79]  R. Rappuoli,et al.  A pneumococcal pilus influences virulence and host inflammatory responses. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[80]  S. Hammerschmidt,et al.  Versatility of pneumococcal surface proteins. , 2006, Microbiology.

[81]  D. Briles,et al.  Mn2+-Dependent Regulation of Multiple Genes in Streptococcus pneumoniae through PsaR and the Resultant Impact on Virulence , 2006, Infection and Immunity.

[82]  S. Hammerschmidt.  Adherence molecules of pathogenic pneumococci. , 2006, Current opinion in microbiology.

[83]  J. Carapetis,et al.  The global burden of group A streptococcal diseases. , 2005, The Lancet. Infectious diseases.

[84]  A. Bisno,et al.  Prospects for a group A streptococcal vaccine: rationale, feasibility, and obstacles--report of a National Institute of Allergy and Infectious Diseases workshop. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[85]  G. Bensi,et al.  Group A Streptococcus produce pilus-like structures containing protective antigens and Lancefield T antigens , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[86]  Bernd Kreikemeyer,et al.  Streptococcus pyogenes Collagen Type I-binding Cpa Surface Protein , 2005, Journal of Biological Chemistry.

[87]  Michael T Laub,et al.  Two-Component Signal Transduction Pathways Regulating Growth and Cell Cycle Progression in a Bacterium: A System-Level Analysis , 2005, PLoS biology.

[88]  B. Kreikemeyer,et al.  MsmR, a specific positive regulator of the Streptococcus pyogenes FCT pathogenicity region and cytolysin‐mediated translocation system genes , 2005, Molecular microbiology.

[89]  R. Rappuoli,et al.  Genome Analysis Reveals Pili in Group B Streptococcus , 2005, Science.

[90]  H. Tettelin,et al.  Identification of a Universal Group B Streptococcus Vaccine by Multiple Genome Screen , 2005, Science.

[91]  G. Lindahl,et al.  Surface Proteins of Streptococcus agalactiae and Related Proteins in Other Bacterial Pathogens , 2005, Clinical Microbiology Reviews.

[92]  B. Kreikemeyer,et al.  The intracellular status of Streptococcus pyogenes: role of extracellular matrix-binding proteins and their regulation. , 2004, International journal of medical microbiology : IJMM.

[93]  O. Schneewind,et al.  Assembly of pili in Gram-positive bacteria. , 2004, Trends in microbiology.

[94]  B. Kreikemeyer,et al.  Streptococcus pyogenes Fibronectin-binding Protein F2 , 2004, Journal of Biological Chemistry.

[95]  A. Camilli,et al.  MgrA, an Orthologue of Mga, Acts as a Transcriptional Repressor of the Genes within the rlrA Pathogenicity Islet in Streptococcus pneumoniae , 2003, Journal of bacteriology.

[96]  A. Camilli,et al.  From nose to lung: the regulation behind Streptococcus pneumoniae virulence factors , 2003, Molecular microbiology.

[97]  B. Eikmanns,et al.  Analysis of RogB-Controlled Virulence Mechanisms and Gene Expression in Streptococcus agalactiae , 2003, Infection and Immunity.

[98]  B. Kreikemeyer,et al.  Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen-host interactions. , 2003, Trends in microbiology.

[99]  T. C. Barnett,et al.  Differential Recognition of Surface Proteins in Streptococcus pyogenes by Two Sortase Gene Homologs , 2002, Journal of bacteriology.

[100]  D. Bessen,et al.  Genomic Localization of a T Serotype Locus to a Recombinatorial Zone Encoding Extracellular Matrix-Binding Proteins in Streptococcus pyogenes , 2002, Infection and Immunity.

[101]  J. Krieglstein,et al.  Phosphorylation and dephosphorylation of histidine residues in proteins. , 2002, European journal of biochemistry.

[102]  H. Courtney,et al.  Molecular mechanisms of adhesion, colonization, and invasion of group A streptococci , 2002, Annals of medicine.

[103]  J. Troendle,et al.  Level of maternal antibody required to protect neonates against early-onset disease caused by group B Streptococcus type Ia: a multicenter, seroepidemiology study. , 2001, The Journal of infectious diseases.

[104]  J. Yother,et al.  Requirement for Capsule in Colonization byStreptococcus pneumoniae , 2001, Infection and Immunity.

[105]  M. Rohde,et al.  The role played by the group A streptococcal negative regulator Nra on bacterial interactions with epithelial cells , 2001, Molecular microbiology.

[106]  B. Kreikemeyer,et al.  Group A Streptococcal rofA Gene Is Involved in the Control of Several Virulence Genes and Eukaryotic Cell Attachment and Internalization , 2001, Infection and Immunity.

[107]  M. Cunningham,et al.  Pathogenesis of group A streptococcal infections. , 2000, Clinical microbiology reviews.

[108]  D. Parsonage,et al.  The RofA Binding Site in Streptococcus pyogenes Is Utilized in Multiple Transcriptional Pathways , 2000, Journal of bacteriology.

[109]  B. Kreikemeyer,et al.  Role of fibronectin-binding MSCRAMMs in bacterial adherence and entry into mammalian cells. , 1999, Matrix biology : journal of the International Society for Matrix Biology.

[110]  A. Podbielski,et al.  Characterization of nra, a global negative regulator gene in group A streptococci , 1999, Molecular microbiology.

[111]  J. Henrichsen,et al.  Six newly recognized types of Streptococcus pneumoniae , 1995, Journal of clinical microbiology.

[112]  M. Caparon,et al.  The identification of rofA, a positive‐acting regulatory component of prtF expression: use of an mγδ‐based shuttle mutagenesis strategy in Streptococcus pyogenes , 1994 .

[113]  M. Jacques,et al.  Ultrastructural study of surface components of Streptococcus suis , 1990, Journal of bacteriology.

[114]  D. Kasper,et al.  Role of antibody to native type III polysaccharide of group B Streptococcus in infant infection. , 1981, Pediatrics.

[115]  V. Dole,et al.  THE PROPERTIES OF T ANTIGENS EXTRACTED FROM GROUP A HEMOLYTIC STREPTOCOCCI , 1946, The Journal of experimental medicine.

[116]  K. Hokamp,et al.  The growth phase-dependent regulation of the pilus locus genes by two-component system TCS08 in Streptococcus pneumoniae. , 2009, Microbial pathogenesis.

[117]  I. Margarit,et al.  Preventing bacterial infections with pilus-based vaccines: the group B streptococcus paradigm. , 2009, The Journal of infectious diseases.

[118]  Anjali Mandlik,et al.  Pili in Gram-positive bacteria: assembly, involvement in colonization and biofilm development. , 2008, Trends in microbiology.

[119]  M. Höök,et al.  MSCRAMM-mediated adherence of microorganisms to host tissues. , 1994, Annual review of microbiology.