PATHO CLINICAL PROFILE OF DENGUE FEVER IN HOSPITALISED CHILDREN

Source of Funding: Self Conflicts of interest: None DOI: 10.16965/ijims.2018.126 Dengue virus infection is recognized as one of the most important mosquito borne human infections in the 21st century. Its incidence has increased in the present decade by 30-fold with increasing geographic expansion to new countries, from urban to rural areas. Estimated 50million dengue infections occur annually and approximately 2.5 billion people live in dengue endemic countries.There has been increasing incidence of dengue fever in this part in recent years. Dengue fever is known to involve multiple systems sometimes resulting multi organ dysfunction. Bleeding manifestation is most common to occur in dengue fever. Hence the following prospective observational study in 500 consecutive patients with dengue fever was study was conducted at Nimra Medical College in 2 years (November 2015 to November 2017) to find out to know the correlation between the clinical bleeding and laboratory parameters which significantly correlate to clinical bleeding in patients with DF, DHF, and DSS.Out of 500 children, 61% belongs to DF among which 98.36% were recovered, 1.63% were expired, 23% belongs to DHF and are 100% recovered, and 16% DSS of which 97.50% were recovered, 2.50% were expired. Bleeding manifestations are very common in dengue infection with altered laboratory parameters. Thus, bleeding manifestations and low platelet count with altered coagulation profile in serologically positive cases can be used to guard the prognosis of dengue fever and DHF.