Serum levels of matrix metalloproteinases 2 and 9 and TGFBR2 gene screening in patients with ascending aortic dilatation.

Development of ascending aortic dilatation (AAD) in about 10 % of patients operated for aortic valve disease (AVD) is probably based on intrinsic pathology of the aortic wall. This may involve an abnormality in the process of extracellular matrix remodelling. The present study evaluated the serum levels of specific metalloproteinases (MMP-2 and MMP-9) and investigated the gene for transforming growth factor receptor 2 (TGFBR2) in 28 patients with AVD associated with AAD (mean age 60.6 years), in 29 patients (68.9 years) with AVD without AAD, and in 30 healthy controls (45.3 years). The serum levels of MMPs were determined by ELISA. Further, we focused on genetic screening of the received February 10, 2013. accepted March 13, 2013. The research was partially supported by the projects Ln00B107 and 1M06014 of the Ministry of education, Youth and sports of the Czech republic and by the long-term strategic development financing of the Institute of Computer Science (RVO:67985807). Corresponding author: Jana Šímová, Department of anthropology and Human genetics, Faculty of science, Charles university in Prague, Viničná 7, 128 43, Prague 2, Czech Republic. e-mail:

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