Expression of the Ha-ras Suppressor Family Member 5 Gene in the Maturing Rat Testis

We analyzed the gene expression of Ha-ras suppressor family member 5 (Hrasls5), which is considered to modulate the Ha-ras signaling cascade, from maturing rat testis. Expression was detected primarily in the spermatocytes in the maturing rat testis. The Hrasls5 gene product might function as a tumor suppressor as well as in spermatogenesis, as deduced from its amino acid sequence.

[1]  G. Cooper,et al.  Specific expression of nuclear proto-oncogenes before entry into meiotic prophase of spermatogenesis. , 1989, Science.

[2]  N. Ueda,et al.  Discovery and Characterization of a Ca2+-independent Phosphatidylethanolamine N-Acyltransferase Generating the Anandamide Precursor and Its Congeners* , 2006, Journal of Biological Chemistry.

[3]  A. Hajnal,et al.  Suppression of ras-mediated transformation. Differential expression of genes encoding extracellular matrix proteins in normal, transformed and revertant cells. , 1993, Advances in enzyme regulation.

[4]  P. Lichter,et al.  Transcriptional and translational downregulation of H-REV107, a class II tumour suppressor gene located on human chromosome 11q11-12 , 1998, Oncogene.

[5]  D. Lowy,et al.  Function and regulation of ras. , 1993, Annual review of biochemistry.

[6]  C. Cordon-Cardo,et al.  Expression of ras proto-oncogene proteins in normal human tissues. , 1987, Oncogene.

[7]  H. Moon,et al.  Orchiectomy reduces hepatotumorigenesis of H-ras12V transgenic mice via the MAPK pathway. , 2006, Life sciences.

[8]  M. Mattei,et al.  hH-Rev107, a class II tumor suppressor gene, is expressed by post-meiotic testicular germ cells and CIS cells but not by human testicular germ cell tumors , 2001, Oncogene.

[9]  M. Wigler,et al.  Analysis of the transforming potential of the human H-ras gene by random mutagenesis. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[10]  R. Schäfer,et al.  Growth-inhibitory Activity and Downregulation of the Class II Tumor-suppressor Gene H-rev107 in Tumor Cell Lines and Experimental Tumors , 1997, The Journal of cell biology.

[11]  H. Ito,et al.  Isolation, characterization, and chromosome mapping of a human A-C1 Ha-Ras suppressor gene (HRASLS) , 2001, Cytogenetic and Genome Research.

[12]  M. Giorgi,et al.  Expression of cellular protooncogenes in the mouse male germ line: a distinctive 2.4-kilobase pim-1 transcript is expressed in haploid postmeiotic cells. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[13]  I. Morishima,et al.  Expression of small stress protein hsp20 gene in the maturing rat testis. , 2005, The Journal of veterinary medical science.

[14]  S. Nagdas,et al.  Identification of Ras and Its Downstream Signaling Elements and Their Potential Role in Hamster Sperm Motility1 , 2002, Biology of reproduction.

[15]  A. Hajnal,et al.  Subtraction cloning of H-rev107, a gene specifically expressed in H-ras resistant fibroblasts. , 1994, Oncogene.

[16]  Takashi Nakamura,et al.  Molecular Cloning and Biological Activity of a Novel Ha-Ras Suppressor Gene Predominantly Expressed in Skeletal Muscle, Heart, Brain, and Bone Marrow by Differential Display Using Clonal Mouse EC Cells, ATDC5* , 1999, The Journal of Biological Chemistry.

[17]  Sam W. Lee,et al.  Positive selection of candidate tumor-suppressor genes by subtractive hybridization. , 1991, Proceedings of the National Academy of Sciences of the United States of America.