A Novel Configuration of Modular Bipolar Pulse Generator Topology Based on Marx Generator With Double Power Charging

A bipolar pulse has been proved to be more advanced in the treatment of tumor because of the elimination of muscle contractions and the effect for ablating nonuniform tissue. In this paper, a new type of modular bipolar pulsed-power generator based on Marx generator with double power charging is proposed. The concept of this generator is charging the two series of capacitors in parallel by two power sources, respectively, and then connecting the capacitors in series through solid-state switches with different control strategies. Utilizing a number of fast solid-state switches, the capacitors can be connected in series with different polarities, so that a positive or negative polarity pulse will be delivered to the load. The simulated models of this generator have been investigated in a PSPICE platform, and a laboratory prototype has been implemented in a laboratory. The simulation and test results verify the operation of the proposed topology in different switching modes. The development of this pulse generator can provide the hardware foundation for the research on biological effect without muscle contraction when the tumors are applied with bipolar pulse electric field.

[1]  Jiande Zhang,et al.  High-voltage pulse generator based on magnetic pulse compression and transmission line transformer , 2013, 2013 19th IEEE Pulsed Power Conference (PPC).

[2]  Ma Long,et al.  A novel generator for high-voltage bipolar square pulses with applications in sterilization of microorganism , 2015, IEEE Transactions on Dielectrics and Electrical Insulation.

[3]  Matthew R. DeWitt,et al.  In-vitro bipolar nano- and microsecond electro-pulse bursts for irreversible electroporation therapies. , 2014, Bioelectrochemistry.

[4]  Salvador Portillo,et al.  Characterization and analysis of a pulse forming network based 11 stage Marx system for a high power microwave, plasma and beam physics test stand , 2014, 2014 IEEE 41st International Conference on Plasma Sciences (ICOPS) held with 2014 IEEE International Conference on High-Power Particle Beams (BEAMS).

[5]  Arindam Ghosh,et al.  A Novel High-Voltage Pulsed-Power Supply Based on Low-Voltage Switch–Capacitor Units , 2009 .

[6]  A. J. Cousin,et al.  The design of a high voltage scr pulse generator for ultrasonic pulse echo applications , 1979 .

[7]  Paulo A. Garcia,et al.  High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction , 2011, Biomedical engineering online.

[8]  Damijan Miklavcic,et al.  The effect of high frequency electric pulses on muscle contractions and antitumor efficiency in vivo for a potential use in clinical electrochemotherapy. , 2005, Bioelectrochemistry.

[9]  A. Ghosh,et al.  High-Voltage Modular Power Supply Using Parallel and Series Configurations of Flyback Converter for Pulsed Power Applications , 2012, IEEE Transactions on Plasma Science.

[10]  X. Wang,et al.  Marx generator using power mosfets , 2009, 2009 IEEE Pulsed Power Conference.

[11]  Helen Kavnoudias,et al.  Irreversible Electroporation: A New Challenge in “Out of Operating Theater” Anesthesia , 2010, Anesthesia and analgesia.

[12]  H. Canacsinh,et al.  Bipolar solid state arbitrary-waveform Marx generator for capacitive loads , 2011, 2011 IEEE Pulsed Power Conference.

[13]  L.M. Redondo,et al.  New Repetitive Bipolar Solid-State Marx Type Modulator , 2008, 2008 IEEE International Power Modulators and High-Voltage Conference.

[14]  W. J. Carey,et al.  Marx generator design and performance , 2002, Conference Record of the Twenty-Fifth International Power Modulator Symposium, 2002 and 2002 High-Voltage Workshop..

[15]  J. E. Dolan.  Pulsed power - principles and applications , 2004 .

[16]  Chenguo Yao,et al.  FPGA-Controlled All-Solid-State Nanosecond Pulse Generator for Biological Applications , 2012, IEEE Transactions on Plasma Science.

[17]  Akira Tokuchi,et al.  Pulsed Power Generation by Solid-State LTD , 2014, IEEE Transactions on Plasma Science.

[18]  Jiancang Su,et al.  A Long-Pulse Generator Based on Tesla Transformer and Pulse-Forming Network , 2009, IEEE Transactions on Plasma Science.

[19]  Hidenori Akiyama,et al.  Solid-State Dual Marx Generator With a Short Pulsewidth , 2013, IEEE Transactions on Plasma Science.

[20]  Jian Qiu,et al.  All-Solid-State Repetitive Pulsed-Power Generator Using IGBT and Magnetic Compression Switches , 2010, IEEE Transactions on Plasma Science.