Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin.

The anticonvulsants ethosuximide, sodium valproate, and trimethadione that are specific for petit mal epilepsy abolished in rats the electrical seizure activity and behavioral abnormalities produced by leucine enkephalin, whereas phenobarbital and phenytoin had no effect. The dose-response curve for naloxone against seizure activity induced by leucine enkephalin was the same as that in gamma-hydroxybutyrate-induced petit mal. These data indicate that the epileptic properties of leucine enkephalin are petit mal-like and raise the possibility of involvement of enkephalinergic systems in. The dose-response curve for naloxone against seizure activity induced by leucine enkephalin was the same as that in gamma-hydroxybutyrate-induced petit mal. These data indicate that the epileptic properties of leucine enkephalin are petit mal-like and raise the possibility of involvement of enkephalinergic systems in petit mal epilepsy.

[1]  O. Snead,et al.  Naloxone overcomes the dopaminergic, EEG, and behavioral effects of γ‐hydroxybutyrahe , 1980, Neurology.

[2]  Pegram Gv,et al.  Antagonism of gamma-hydroxybutyric acid-induced frequency shifts in the cortical EEG of rats by dipropylacetate. , 1980, Electroencephalography and clinical neurophysiology.

[3]  O. Snead,et al.  Effect of acute and chronic anticonvulsant administration on endogenous γ-hydroxybutyrate in rat brain , 1980, Neuropharmacology.

[4]  E. J. Simon,et al.  3H-ethylketocyclazocine binding: Lack of evidence for a separate κ receptor in rats CNS , 1979 .

[5]  J. Engel,et al.  Endogenous opiods may mediate post-ictal behavioral depression in amygdaloid-kindled rats , 1979, Brain Research.

[6]  P. Cuatrecasas,et al.  Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity. , 1979, The Journal of biological chemistry.

[7]  M. E. Corcoran,et al.  Naloxone and the kindling of seizures. , 1979, Life sciences.

[8]  F. Leslie,et al.  COMPARISON OF THE RECEPTOR BINDING CHARACTERISTICS OF OPIATE AGONISTS INTERACTING WITH μ‐ OR K‐RECEPTORS , 1978 .

[9]  O. Snead.  Gamma hydroxybutyrate in the monkey , 1978, Neurology.

[10]  F. Bloom,et al.  beta-Endorphin induces nonconvulsive limbic seizures. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[11]  B. Wilder,et al.  Effect of valproic acid on spike and wave discharges in patients with absence seizures , 1978, Neurology.

[12]  O. Snead.  Gamma hydroxybutyrate in the monkey , 1978, Neurology.

[13]  O. Snead.  Gamma hydroxybutyrate in the monkey , 1978, Neurology.

[14]  H. Frenk,et al.  Epileptic properties of leucine- and methionine-enkephalin: Comparison with morphine and reversibility by naloxone , 1978, Brain Research.

[15]  H. Frenk,et al.  Different brain areas mediate the analgesic and epileptic properties of enkephalin. , 1978, Science.

[16]  H. Frenk,et al.  Morphine and enkephalin: analgesic and epileptic properties. , 1977, Science.

[17]  John Hughes,et al.  Endogenous opioid peptides: multiple agonists and receptors , 1977, Nature.

[18]  W. Martin,et al.  The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog. , 1976, The Journal of pharmacology and experimental therapeutics.

[19]  J. Thompson,et al.  The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. , 1976, The Journal of pharmacology and experimental therapeutics.

[20]  W. D. Winters,et al.  Neuropharmacological effects induced by butanol, 4-hydroxybutyrate, 4-mercaptobutyric acid thiolactone, tetrahydrofuran, pyrrolidine, 2-deoxy-d-glucose and related substances in the rat , 1976, Neuropharmacology.

[21]  P. Huttenlocher,et al.  Gamma hydroxybutyrate , 1976, Neurology.

[22]  H. Morris,et al.  Identification of two related pentapeptides from the brain with potent opiate agonist activity , 1975, Nature.

[23]  F. Dreifuss,et al.  Ethosuximide in the treatment of absence (petit mal) seizures , 1975, Neurology.

[24]  J. Aicardi.  [Drugs for petit mal]. , 1975, Therapie.

[25]  E. Schoener,et al.  Antagonism of pentylenetetrazol excitation by anticonvulsants on single brain stem neurons. , 1972, Neuropharmacology.

[26]  W. D. Winters,et al.  EEG and behavioral comparison of the effects of gamma-hydroxybutyrate, gamma-butyrolactone and short chain fatty acids in the rat. , 1967, International journal of neuropharmacology.

[27]  Bateman Jc.  Can chemotherapeutic perfusion of pelvic viscera palliate patients with advanced or recurrent cervical cancer , 1965 .

[28]  E. Niedermeyer,et al.  Petit Mai Status (“Spike‐Wave Stupor”) An electro‐clinical appraisal , 1965, Epilepsia.

[29]  W. D. Winters,et al.  VARIOUS SEIZURE ACTIVITIES FOLLOWING GAMMA-HYDROXYBUTYRATE. , 1965, International journal of neuropharmacology.

[30]  F. Dreifuss,et al.  Simultaneous recording of absence seizures with video tape and electroencephalography. A study of 374 seizures in 48 patients. , 1975, Brain : a journal of neurology.