SYSTEMIC THERAPY OF MODERATE AND SEVERE PSORIASIS WITH METHOTREXATE

The systemic treatment in psoriatic disease is addressed particularly to the severe forms of psoriasis with a PASI> 10. It consists of both conventional therapies (methotrexate, PUVA, cyclosporine, retinoids) and modern therapies with biological preparats. In this study we made a comparative assessment of the effectiveness and tolerance of systemic treatment with methotrexate both as monotherapy and in combination with SUP phototherapy, for patients with psoriasis vulgaris.

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