High-Resolution Brain 18F-FDG Images Provided by Fully Digital PET.

Normal brain F-FDG PET images, consecutively recorded on analog and fully digital PET cameras in an 85-year-old woman, are depicted herein with the reconstruction methods recommended for a 2-mm voxel size on each camera and with a high-resolution reconstruction additionally developed for digital PET with a 1-mm voxel size. An enhanced gray-to-white matter contrast was consistently documented for digital PET when compared with analog PET, and was associated with a further enhancement in spatial resolution at 1-mm voxel size, as evidenced by a much clearer delineation of cortical gyri. These high-resolution images could favor the identification of brain abnormalities.

[1]  F Nobili,et al.  European Association of Nuclear Medicine and European Academy of Neurology recommendations for the use of brain 18F‐fluorodeoxyglucose positron emission tomography in neurodegenerative cognitive impairment and dementia: Delphi consensus , 2018, European journal of neurology.

[2]  P. Marie,et al.  Central Nervous System Myelomatosis Delineated by High-Resolution Brain Images From Fully Digital 18F-FDG PET. , 2018, Clinical nuclear medicine.

[3]  A. Drzezga,et al.  EANM-EAN recommendations for the use of brain 18 F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in neurodegenerative cognitive impairment and dementia: Delphi consensus , 2018 .

[4]  W. Moses.  Fundamental Limits of Spatial Resolution in PET. , 2011, Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment.

[5]  Koen Van Laere,et al.  EANM procedure guidelines for PET brain imaging using [18F]FDG, version 2 , 2009, European Journal of Nuclear Medicine and Molecular Imaging.

[6]  Ian Law,et al.  Clinical PET/MR Imaging in Dementia and Neuro-Oncology. , 2016, PET clinics.

[7]  H. Malcolm Hudson,et al.  Accelerated image reconstruction using ordered subsets of projection data , 1994, IEEE Trans. Medical Imaging.

[8]  R. Holen,et al.  Healthy brain ageing assessed with 18F-FDG PET and age-dependent recovery factors after partial volume effect correction , 2017, European Journal of Nuclear Medicine and Molecular Imaging.

[9]  L. Lucy.  An iterative technique for the rectification of observed distributions , 1974 .

[10]  T. Frach,et al.  The digital silicon photomultiplier — Principle of operation and intrinsic detector performance , 2009, 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC).

[11]  William H. Richardson,et al.  Bayesian-Based Iterative Method of Image Restoration , 1972 .