A Bio-Inspired Two-Layer Sensing Structure of Polypeptide and Multiple-Walled Carbon Nanotube to Sense Small Molecular Gases

In this paper, we propose a bio-inspired, two-layer, multiple-walled carbon nanotube (MWCNT)-polypeptide composite sensing device. The MWCNT serves as a responsive and conductive layer, and the nonselective polypeptide (40 mer) coating the top of the MWCNT acts as a filter into which small molecular gases pass. Instead of using selective peptides to sense specific odorants, we propose using nonselective, peptide-based sensors to monitor various types of volatile organic compounds. In this study, depending on gas interaction and molecular sizes, the randomly selected polypeptide enabled the recognition of certain polar volatile chemical vapors, such as amines, and the improved discernment of low-concentration gases. The results of our investigation demonstrated that the polypeptide-coated sensors can detect ammonia at a level of several hundred ppm and barely responded to triethylamine.

[1]  N S Lewis,et al.  An investigation of the concentration dependence and response to analyte mixtures of carbon black/insulating organic polymer composite vapor detectors. , 2000, Analytical chemistry.

[2]  Junya Suehiro,et al.  Schottky-type response of carbon nanotube NO2 gas sensor fabricated onto aluminum electrodes by dielectrophoresis , 2006 .

[3]  Steven Teitelbaum,et al.  Where are the data? , 2011, Plastic and reconstructive surgery.

[4]  Hoeil Chung,et al.  Sensitive detection of an anthrax biomarker using a glassy carbon electrode with a consecutively immobilized layer of polyaniline/carbon nanotube/peptide. , 2011, Biosensors & bioelectronics.

[5]  Li-Chun Wang,et al.  A Single-Walled Carbon Nanotube Network Gas Sensing Device , 2011, Sensors.

[6]  N. Lewis.  Comparisons between mammalian and artificial olfaction based on arrays of carbon black-polymer composite vapor detectors. , 2004, Accounts of chemical research.

[7]  Julian W. Gardner,et al.  Review of Conventional Electronic Noses and Their Possible Application to the Detection of Explosives , 2004 .

[8]  E. S. Snow,et al.  Chemical Detection with a Single-Walled Carbon Nanotube Capacitor , 2005, Science.

[9]  N S Lewis,et al.  Low power, lightweight vapor sensing using arrays of conducting polymer composite chemically-sensitive resistors. , 2001, Enantiomer.

[10]  T. Someya,et al.  Alcohol Vapor Sensors Based on Single-Walled Carbon Nanotube Field Effect Transistors , 2003 .

[11]  R. Reed,et al.  Signaling pathways in odorant detection , 1992, Neuron.

[12]  Uwe Lampe,et al.  Thin-film gas sensors based on semiconducting metal oxides , 1995 .

[13]  N S Lewis,et al.  Trends in odor intensity for human and electronic noses: relative roles of odorant vapor pressure vs. molecularly specific odorant binding. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[14]  J. Huh,et al.  Effect of NH3 gas on the electrical properties of single-walled carbon nanotube bundles , 2006 .

[15]  Eric S. Snow,et al.  Random networks of carbon nanotubes as an electronic material , 2003 .

[16]  Nathan S. Lewis,et al.  Array-based vapor sensing using chemically sensitive carbon black-polymer resistors , 1997, Defense, Security, and Sensing.

[17]  Julian W. Gardner,et al.  Application of conducting polymer technology in microsystems , 1995 .

[18]  Masanobu Matsuguchi,et al.  Poly(acrylamide) derivatives for QCM-based HCl gas sensor applications , 2008 .

[19]  Saurabh Chopra,et al.  Carbon-nanotube-based resonant-circuit sensor for ammonia , 2002 .

[20]  H. Eto,et al.  Electronic noses-development and future prospects , 2022 .

[21]  Jonathan M. Slater,et al.  Multi-layer conducting polymer gas sensor arrays for olfactory sensing , 1993 .

[22]  Seung-Chul Ha,et al.  Portable electronic nose system based on the carbon black–polymer composite sensor array , 2005 .

[23]  Sindhuja Sankaran,et al.  Olfactory receptor based piezoelectric biosensors for detection of alcohols related to food safety applications , 2011 .

[24]  Nguyen Van Hieu,et al.  Highly sensitive thin film NH3 gas sensor operating at room temperature based on SnO2/MWCNTs composite , 2008 .

[25]  Christophe Ramseyer,et al.  Direct growth of the multi-walled carbon nanotubes as a tool to detect ammonia at room temperature , 2006 .

[26]  K. Tang,et al.  A bio-inspired two-layer multiple-walled carbon nanotube-polymer composite sensor array and a bio-inspired fast-adaptive readout circuit for a portable electronic nose. , 2011, Biosensors & bioelectronics.

[27]  Nathali Kaushansky,et al.  The polymer-coated SAW sensor as a gravimetric sensor , 1997 .

[28]  H. Troy Nagle,et al.  Handbook of Machine Olfaction: Electronic Nose Technology , 2003 .

[29]  M. Ryan,et al.  Polymer—Carbon Black Composite Sensors in an Electronic Nose for Air-Quality Monitoring , 2004, MRS bulletin.

[30]  Masanobu Matsuguchi,et al.  Molecular imprinting strategy for solvent molecules and its application for QCM-based VOC vapor sensing , 2006 .

[31]  S. Orlanducci,et al.  Role of the Material Electrodes on Resistive Behaviour of Carbon Nanotube-Based Gas Sensors for H2S Detection , 2012, J. Sensors.

[32]  Wolfgang Göpel,et al.  SnO2 sensors: current status and future prospects☆ , 1995 .

[33]  R. Axel,et al.  A novel multigene family may encode odorant receptors: A molecular basis for odor recognition , 1991, Cell.

[34]  C. Hagleitner,et al.  Smart single-chip gas sensor microsystem , 2001, Nature.

[35]  Bing R. Hsieh,et al.  Fluorescent conjugated polymer films as TNT chemosensors , 2004 .

[36]  Chang-Pin Chang,et al.  The fabrication of a MWNTs–polymer composite chemoresistive sensor array to discriminate between chemical toxic agents , 2009 .