Identification of candidate biomarkers of brain damage in a mouse model of closed head injury: a metabolomic pilot study

[1]  David S. Wishart,et al.  MetaboAnalyst 3.0—making metabolomics more meaningful , 2015, Nucleic Acids Res..

[2]  A. Rotenberg,et al.  Glutamate and GABA Imbalance Following Traumatic Brain Injury , 2015, Current Neurology and Neuroscience Reports.

[3]  K. Prasad,et al.  Common biochemical defects linkage between post-traumatic stress disorders, mild traumatic brain injury (TBI) and penetrating TBI , 2015, Brain Research.

[4]  T. Carpenter,et al.  Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings , 2014, Metabolic Brain Disease.

[5]  David S. Wishart,et al.  Accurate, Fully-Automated NMR Spectral Profiling for Metabolomics , 2014, PloS one.

[6]  Keizo Takao,et al.  Genomic responses in mouse models greatly mimic human inflammatory diseases , 2014, Proceedings of the National Academy of Sciences.

[7]  B. Green,et al.  Metabolic signatures of human Alzheimer’s disease (AD): 1H NMR analysis of the polar metabolome of post-mortem brain tissue , 2014, Metabolomics.

[8]  Isidre Ferrer,et al.  Metabolomics of human brain aging and age-related neurodegenerative diseases. , 2014, Journal of neuropathology and experimental neurology.

[9]  Yun Wang,et al.  Dynamic metabolites profile of cerebral ischemia/reperfusion revealed by (1)H NMR-based metabolomics contributes to potential biomarkers. , 2014, International journal of clinical and experimental pathology.

[10]  R. Diaz-Arrastia,et al.  Military traumatic brain injury: A review , 2014, Alzheimer's & Dementia.

[11]  P. Stahel,et al.  Deficiency of complement receptors CR2/CR1 in Cr2-/- mice reduces the extent of secondary brain damage after closed head injury , 2014, Journal of Neuroinflammation.

[12]  P. Stahel,et al.  Serum Biomarkers for Traumatic Brain Injury , 2014, Southern medical journal.

[13]  A. Rodríguez-Rodríguez,et al.  Oxidative stress in traumatic brain injury. , 2014, Current medicinal chemistry.

[14]  A. Logan,et al.  The Molecular Mechanisms Affecting N-Acetylaspartate Homeostasis Following Experimental Graded Traumatic Brain Injury , 2014, Molecular medicine.

[15]  G. Fiskum,et al.  Cerebral glucose metabolism in an immature rat model of pediatric traumatic brain injury. , 2013, Journal of neurotrauma.

[16]  B. Green,et al.  Metabolic signatures of human Alzheimer’s disease (AD): 1H NMR analysis of the polar metabolome of post-mortem brain tissue , 2013, Metabolomics.

[17]  T. Popović,et al.  CDC Grand Rounds: Reducing Severe Traumatic Brain Injury in the United States , 2013, MMWR. Morbidity and mortality weekly report.

[18]  M. Simmaco,et al.  The omics in migraine , 2013, The Journal of Headache and Pain.

[19]  Kaj Blennow,et al.  Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers , 2013, Nature Reviews Neurology.

[20]  C. Elliott,et al.  1H NMR metabolomics investigation of an Alzheimer’s disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma , 2013, Metabolomics.

[21]  R. Gamelli,et al.  Genomic responses in mouse models poorly mimic human inflammatory diseases , 2013, Proceedings of the National Academy of Sciences.

[22]  C. Hölscher,et al.  Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease. , 2013, Analytical chemistry.

[23]  M. Fitzpatrick,et al.  Metabolomics--a novel window into inflammatory disease. , 2013, Swiss medical weekly.

[24]  K. Guskiewicz,et al.  American Medical Society for Sports Medicine Position Statement: Concussion in Sport , 2013, Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine.

[25]  D. Wishart,et al.  The Metabolomic Profile of Umbilical Cord Blood in Neonatal Hypoxic Ischaemic Encephalopathy , 2012, PloS one.

[26]  D. Wishart,et al.  Translational biomarker discovery in clinical metabolomics: an introductory tutorial , 2012, Metabolomics.

[27]  David S. Wishart,et al.  HMDB 3.0—The Human Metabolome Database in 2013 , 2012, Nucleic Acids Res..

[28]  J. Stover,et al.  Changes in plasma phenylalanine, isoleucine, leucine, and valine are associated with significant changes in intracranial pressure and jugular venous oxygen saturation in patients with severe traumatic brain injury , 2012, Amino Acids.

[29]  David S. Wishart,et al.  MetaboAnalyst 2.0—a comprehensive server for metabolomic data analysis , 2012, Nucleic Acids Res..

[30]  R. Boellaard,et al.  Increased cerebral (R)-[11C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study , 2011, Journal of Neuroinflammation.

[31]  F. Franconi,et al.  High resolution nuclear magnetic resonance investigation of metabolic disturbances induced by focal traumatic brain injury in a rat model: a pilot study , 2011 .

[32]  J. Pickard,et al.  Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients. , 2011, Brain : a journal of neurology.

[33]  Roberto Sorge,et al.  Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients. , 2010, Brain : a journal of neurology.

[34]  C. Robertson,et al.  Role of extracellular glutamate measured by cerebral microdialysis in severe traumatic brain injury. , 2010, Journal of neurosurgery.

[35]  Garnette R Sutherland,et al.  The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study. , 2009, Brain : a journal of neurology.

[36]  Philip F Stahel,et al.  Mouse closed head injury model induced by a weight-drop device , 2009, Nature Protocols.

[37]  David S. Wishart,et al.  MetaboAnalyst: a web server for metabolomic data analysis and interpretation , 2009, Nucleic Acids Res..

[38]  David S. Wishart,et al.  HMDB: a knowledgebase for the human metabolome , 2008, Nucleic Acids Res..

[39]  Chad M. Miller,et al.  Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury* , 2008, Critical care medicine.

[40]  G. Fiskum,et al.  Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats. , 2008, Journal of neurotrauma.

[41]  Pilar López-Larrubia,et al.  Time course of early metabolic changes following diffuse traumatic brain injury in rats as detected by (1)H NMR spectroscopy. , 2007, Journal of neurotrauma.

[42]  Ying Zhang,et al.  HMDB: the Human Metabolome Database , 2007, Nucleic Acids Res..

[43]  P. Kochanek,et al.  Oxidative Stress in Immature Brain after Traumatic Brain Injury , 2006, Developmental Neuroscience.

[44]  Mark R Viant,et al.  An NMR metabolomic investigation of early metabolic disturbances following traumatic brain injury in a mammalian model , 2005, NMR in biomedicine.

[45]  C. Dinarello,et al.  Elevated Intracranial IL-18 in Humans and Mice after Traumatic Brain Injury and Evidence of Neuroprotective Effects of IL-18—Binding Protein after Experimental Closed Head Injury , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[46]  W M Brooks,et al.  Magnetic resonance spectroscopy in traumatic brain injury. , 2001, The Journal of head trauma rehabilitation.

[47]  V. Hans,et al.  Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue , 1997, Molecular Psychiatry.

[48]  Xiang Yang Chen,et al.  Operant conditioning of H-reflex in spinal cord-injured rats. , 1996, Journal of neurotrauma.

[49]  S. Constantini,et al.  An experimental model of closed head injury in mice: pathophysiology, histopathology, and cognitive deficits. , 1996, Journal of neurotrauma.

[50]  P. Magistretti,et al.  Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[51]  Lisa J. Martin,et al.  Genetics and outcomes after traumatic brain injury (TBI): what do we know about pediatric TBI? , 2012, Journal of pediatric rehabilitation medicine.

[52]  Garrett W. Wood,et al.  Brain Injuries from Blast , 2011, Annals of Biomedical Engineering.

[53]  David S Wishart,et al.  Computational approaches to metabolomics. , 2010, Methods in molecular biology.

[54]  A. Hyder,et al.  The impact of traumatic brain injuries: a global perspective. , 2007, NeuroRehabilitation.

[55]  R. Yolken,et al.  Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress , 2004, Molecular Psychiatry.

[56]  Tom Fawcett,et al.  ROC Graphs: Notes and Practical Considerations for Data Mining Researchers , 2003 .

[57]  Ernö Pretsch,et al.  1 H-NMR , 1976 .