Involvement of Nrf2-GSH signaling in TGFβ1-stimulated epithelial-to-mesenchymal transition changes in rat renal tubular cells

[1]  Kenji Suzuki,et al.  Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway. , 2013, Molecular nutrition & food research.

[2]  Peisong Chen,et al.  Epithelial-mesenchymal transition of renal tubules: divergent processes of repairing in acute or chronic injury? , 2013, Medical hypotheses.

[3]  V. Besnard,et al.  Nuclear factor erythroid 2-related factor 2 nuclear translocation induces myofibroblastic dedifferentiation in idiopathic pulmonary fibrosis. , 2013, Antioxidants & redox signaling.

[4]  T. Kavanagh,et al.  Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model. , 2012, Free radical biology & medicine.

[5]  Robert A. Harris,et al.  Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling. , 2012, Free radical biology & medicine.

[6]  R. Mason,et al.  Epithelial‐mesenchymal transition in renal fibrosis – evidence for and against , 2011, International journal of experimental pathology.

[7]  P. Maher,et al.  Control of redox state and redox signaling by neural antioxidant systems. , 2011, Antioxidants & redox signaling.

[8]  中村 俊信 Attenuation of transforming growth factor-β-stimulated collagen production in fibroblasts by quercetin-induced heme oxygenase-1 , 2011 .

[9]  Rainer Blasczyk,et al.  Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. , 2010, Biochemical pharmacology.

[10]  N. Kashihara,et al.  Oxidative stress in diabetic nephropathy. , 2010, Current medicinal chemistry.

[11]  M. Kwak,et al.  The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis. , 2010, Free radical biology & medicine.

[12]  M. Kwak,et al.  Targeting NRF2 signaling for cancer chemoprevention. , 2010, Toxicology and applied pharmacology.

[13]  Yi-feng Lin,et al.  The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy , 2010, Diabetes.

[14]  R. Liu,et al.  Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis. , 2010, Free radical biology & medicine.

[15]  H. Abboud,et al.  NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts. , 2010, Journal of the American Society of Nephrology : JASN.

[16]  Yuba Raj Pokharel,et al.  Inhibition of liver fibrosis by solubilized coenzyme Q10: Role of Nrf2 activation in inhibiting transforming growth factor-beta1 expression. , 2009, Toxicology and applied pharmacology.

[17]  G. Wolf,et al.  TGF-beta and fibrosis in different organs - molecular pathway imprints. , 2009, Biochimica et biophysica acta.

[18]  D. Knight,et al.  Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1. , 2009, American journal of respiratory and critical care medicine.

[19]  Raghu Kalluri,et al.  The basics of epithelial-mesenchymal transition. , 2009, The Journal of clinical investigation.

[20]  Takafumi Suzuki,et al.  Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity , 2008, Molecular and Cellular Biology.

[21]  M. Freeman,et al.  Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway. , 2008, Cancer research.

[22]  M. Simonson,et al.  Phenotypic transitions and fibrosis in diabetic nephropathy. , 2007, Kidney international.

[23]  P. Ancel,et al.  Risk Factors for Early Epithelial to Mesenchymal Transition in Renal Grafts , 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[24]  F Verrecchia,et al.  [Cellular and molecular mechanisms of fibrosis]. , 2006, Annales de pathologie.

[25]  Young-Chae Chang,et al.  TGF-beta1 siRNA suppresses the tubulointerstitial fibrosis in the kidney of ureteral obstruction. , 2006, Experimental and molecular pathology.

[26]  Raghu Kalluri,et al.  The epithelial–mesenchymal transition: new insights in signaling, development, and disease , 2006, The Journal of cell biology.

[27]  R. Mason,et al.  TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT) , 2005, Respiratory research.

[28]  A. Nicholson,et al.  Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. , 2005, The American journal of pathology.

[29]  David W. Johnson,et al.  Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants. , 2005, Kidney international.

[30]  Makoto Kobayashi,et al.  Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. , 2005, Antioxidants & redox signaling.

[31]  C. Arteaga,et al.  Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins. , 2005, Free radical biology & medicine.

[32]  J. West-Mays,et al.  Transient overexpression of TGF-{beta}1 induces epithelial mesenchymal transition in the rodent peritoneum. , 2005, Journal of the American Society of Nephrology : JASN.

[33]  J. Zavadil,et al.  TGF-beta and epithelial-to-mesenchymal transitions. , 2005, Oncogene.

[34]  Mark Hannink,et al.  Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex , 2004, Molecular and Cellular Biology.

[35]  Masayuki Yamamoto,et al.  Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2 , 2004, Molecular and Cellular Biology.

[36]  Paul Talalay,et al.  Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Youhua Liu Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. , 2004, Journal of the American Society of Nephrology : JASN.

[38]  A. Roberts,et al.  Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. , 2003, The Journal of clinical investigation.

[39]  T. Kavanagh,et al.  TGFβ1‐induced suppression of glutathione antioxidant defenses in hepatocytes: caspase‐dependent posttranslational and caspase‐independent transcriptional regulatory mechanisms , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[40]  M. Kwak,et al.  Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway IDENTIFICATION OF NOVEL GENE CLUSTERS FOR CELL SURVIVAL* , 2003 .

[41]  R. Derynck,et al.  Smad-dependent and Smad-independent pathways in TGF-beta family signalling. , 2003, Nature.

[42]  E. Neilson,et al.  Evidence that fibroblasts derive from epithelium during tissue fibrosis. , 2002, The Journal of clinical investigation.

[43]  M. Rastaldi,et al.  Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. , 2002, Kidney international.

[44]  J. D. Engel,et al.  Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. , 1999, Genes & development.