A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control.

[1]  M. Nussenzweig,et al.  Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix , 2014, Science.

[2]  A. Regev,et al.  The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells , 2014, Nature Immunology.

[3]  Burton E. Barnett,et al.  Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection. , 2014, Immunity.

[4]  M. Kaplan,et al.  Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation. , 2013, Immunity.

[5]  W. Shi,et al.  The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells , 2013, Nature Immunology.

[6]  E. Zúñiga,et al.  Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4⁺ T cell responses and viral control during chronic infection. , 2013, Immunity.

[7]  K. Murphy,et al.  Specificity through cooperation: BATF–IRF interactions control immune-regulatory networks , 2013, Nature Reviews Immunology.

[8]  E John Wherry,et al.  Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory. , 2012, Immunity.

[9]  Richard Bonneau,et al.  A Validated Regulatory Network for Th17 Cell Specification , 2012, Cell.

[10]  Lu Wang,et al.  BATF-JUN is critical for IRF4-mediated transcription in T cells , 2012, Nature.

[11]  Michael Y. Gerner,et al.  CD4 T follicular helper cell dynamics during SIV infection. , 2012, The Journal of clinical investigation.

[12]  E. Zúñiga,et al.  Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection , 2011, Science.

[13]  K. Sakimura,et al.  Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression , 2011, Proceedings of the National Academy of Sciences.

[14]  E. Wherry T cell exhaustion , 2011, Nature Immunology.

[15]  A. Intlekofer,et al.  T-bet represses expression of PD-1 and sustains virus-specific CD8 T cell responses during chronic infection , 2011, Nature Immunology.

[16]  D. McGavern,et al.  Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells , 2011, The Journal of experimental medicine.

[17]  D. Kaufmann,et al.  HIV-specific CD4 T cells and immune control of viral replication , 2011, Current opinion in HIV and AIDS.

[18]  A. Zajac,et al.  IL-21 Deficiency Influences CD8 T Cell Quality and Recall Responses following an Acute Viral Infection , 2010, Journal of Immunology.

[19]  Björn Nilsson,et al.  Integrative genomic analysis of HIV-specific CD8+ T cells reveals that PD-1 inhibits T cell function by upregulating BATF , 2010, Nature Medicine.

[20]  B. Walker,et al.  Immunology and the elusive AIDS vaccine , 2010, Nature.

[21]  M. Bevan,et al.  Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. , 2010, Immunity.

[22]  E. Wherry,et al.  Redefining Chronic Viral Infection , 2009, Cell.

[23]  A. Zajac,et al.  A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection , 2009, Science.

[24]  K. Sauer,et al.  IL-21 Is Required to Control Chronic Viral Infection , 2009, Science.

[25]  J. Weber,et al.  IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection , 2009, Science.

[26]  Gary D. Stormo,et al.  The AP-1 transcription factor Batf controls TH17 differentiation , 2009, Nature.

[27]  D. McGavern,et al.  Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection. , 2006, The Journal of clinical investigation.

[28]  R. Ahmed,et al.  Restoring function in exhausted CD8 T cells during chronic viral infection , 2006, Nature.

[29]  L. Teyton,et al.  Intrinsic Functional Dysregulation of CD4 T Cells Occurs Rapidly following Persistent Viral Infection , 2005, Journal of Virology.

[30]  B. Rehermann,et al.  Immunology of hepatitis B virus and hepatitis C virus infection , 2005, Nature Reviews Immunology.

[31]  B. Walker,et al.  Immunopathogenesis and immunotherapy in AIDS virus infections , 2003, Nature Medicine.

[32]  A. Zajac,et al.  Ablation of CD8 and CD4 T Cell Responses by High Viral Loads1 , 2003, The Journal of Immunology.

[33]  N. Mitin,et al.  B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos , 2000, Oncogene.

[34]  L. Weinberger,et al.  Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques , 1999, The Journal of experimental medicine.

[35]  D. Montefiori,et al.  Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. , 1999, Science.

[36]  J. Altman,et al.  Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function , 1998, The Journal of experimental medicine.

[37]  R. Ahmed,et al.  CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection , 1994, Journal of virology.

[38]  R. Zinkernagel,et al.  Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice , 1994, Journal of virology.

[39]  Antonio Polley,et al.  Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection , 2009, Nature Immunology.

[40]  R. Zinkernagel,et al.  CD4+ T-cell induction and effector functions: a comparison of immunity against soluble antigens and viral infections. , 1998, Advances in immunology.