Consensus Recommendations for Evaluation, Interpretation, and Utilization of Computed Tomography and Magnetic Resonance Enterography in Patients With Small Bowel Crohn's Disease.

Computed tomography and magnetic resonance enterography have become routine small bowel imaging tests to evaluate patients with established or suspected Crohn's disease, but the interpretation and use of these imaging modalities can vary widely. A shared understanding of imaging findings, nomenclature, and utilization will improve the utility of these imaging techniques to guide treatment options, as well as assess for treatment response and complications. Representatives from the Society of Abdominal Radiology Crohn's Disease-Focused Panel, the Society of Pediatric Radiology, the American Gastroenterological Association, and other experts, systematically evaluated evidence for imaging findings associated with small bowel Crohn's disease enteric inflammation and established recommendations for the evaluation, interpretation, and use of computed tomography and magnetic resonance enterography in small bowel Crohn's disease. This work makes recommendations for imaging findings that indicate small bowel Crohn's disease, how inflammatory small bowel Crohn's disease and its complications should be described, elucidates potential extra-enteric findings that may be seen at imaging, and recommends that cross-sectional enterography should be performed at diagnosis of Crohn's disease and considered for small bowel Crohn's disease monitoring paradigms. A useful morphologic construct describing how imaging findings evolve with disease progression and response is described, and standard impressions for radiologic reports that convey meaningful information to gastroenterologists and surgeons are presented. ©2018, RSNA, AGA Institute, and Society of Abdominal Radiology This article is being published jointly in Radiology and Gastroenterology.

[1]  J. Fletcher,et al.  MR Imaging of Perianal Crohn Disease. , 2017, Radiology.

[2]  J. Fletcher,et al.  Computed Tomography and Magnetic Resonance Enterography in Crohn's Disease: Assessment of Radiologic Criteria and Endpoints for Clinical Practice and Trials , 2016, Inflammatory bowel diseases.

[3]  J. Fletcher,et al.  Radiological Response Is Associated With Better Long-Term Outcomes and Is a Potential Treatment Target in Patients With Small Bowel Crohn's Disease , 2016, The American Journal of Gastroenterology.

[4]  I. Ordás,et al.  Comparison of Diagnostic Accuracy and Impact of Magnetic Resonance Imaging and Colonoscopy for the Management of Crohn's Disease. , 2016, Journal of Crohn's & colitis.

[5]  M. Gee,et al.  Magnetic resonance imaging of perianal Crohn disease in children , 2016, Pediatric Radiology.

[6]  J. Dillman,et al.  MR enterography–histology comparison in resected pediatric small bowel Crohn disease strictures: can imaging predict fibrosis? , 2016, Pediatric Radiology.

[7]  S. Park DWI at MR Enterography for Evaluating Bowel Inflammation in Crohn Disease. , 2016, AJR. American journal of roentgenology.

[8]  Diego R. Martín,et al.  Magnetic Resonance Enterography Healing and Magnetic Resonance Enterography Remission Predicts Improved Outcome in Pediatric Crohn Disease , 2016, Journal of pediatric gastroenterology and nutrition.

[9]  S. Park,et al.  Diffusion-weighted Magnetic Resonance Enterography for Evaluating Bowel Inflammation in Crohn's Disease: A Systematic Review and Meta-analysis , 2016, Inflammatory bowel diseases.

[10]  H. Ha,et al.  MR Enterography for the Evaluation of Small-Bowel Inflammation in Crohn Disease by Using Diffusion-weighted Imaging without Intravenous Contrast Material: A Prospective Noninferiority Study. , 2016, Radiology.

[11]  P. Rutgeerts,et al.  Magnetic resonance enterography is feasible and reliable in multicenter clinical trials in patients with Crohn's disease, and may help select subjects with active inflammation , 2016, Alimentary pharmacology & therapeutics.

[12]  D. Mitchell,et al.  How to perform and interpret cine MR enterography , 2015, Journal of magnetic resonance imaging : JMRI.

[13]  J. Fletcher,et al.  Clinical characteristics and imaging features of small bowel adenocarcinomas in Crohn’s disease , 2015, Abdominal Imaging.

[14]  Jonathan R Dillman,et al.  Diffusion-weighted MRI in pediatric inflammatory bowel disease. , 2015, AJR. American journal of roentgenology.

[15]  I. Ordás,et al.  Characterization of Inflammation and Fibrosis in Crohn’s Disease Lesions by Magnetic Resonance Imaging , 2015, The American Journal of Gastroenterology.

[16]  J. Fletcher,et al.  Editorial: Characterization of Inflammation and Fibrosis in Crohn’s Disease Lesions by Magnetic Resonance Imaging , 2015, The American Journal of Gastroenterology.

[17]  J. Fletcher,et al.  NSAID enteropathy: appearance at CT and MR enterography in the age of multi-modality imaging and treatment , 2015, Abdominal Imaging.

[18]  D. Grand,et al.  MR enterography in Crohn’s disease: current consensus on optimal imaging technique and future advances from the SAR Crohn’s disease-focused panel , 2015, Abdominal Imaging.

[19]  J. Fletcher,et al.  CT enterography for Crohn’s disease: optimal technique and imaging issues , 2015, Abdominal Imaging.

[20]  J. Fletcher,et al.  CT and MR enterography in Crohn’s disease: current and future applications , 2015, Abdominal Imaging.

[21]  S. Park,et al.  Diffusion-weighted MR Enterography for Evaluating Crohn's Disease: How Does It Add Diagnostically to Conventional MR Enterography? , 2015, Inflammatory bowel diseases.

[22]  A. Griffiths,et al.  Systematic review with meta‐analysis: magnetic resonance enterography signs for the detection of inflammation and intestinal damage in Crohn's disease , 2015, Alimentary pharmacology & therapeutics.

[23]  K. Yao,et al.  Mucosal healing of ileal lesions is associated with long‐term clinical remission after infliximab maintenance treatment in patients with Crohn's disease , 2015, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society.

[24]  S. Punwani,et al.  Lymphoid nodular hyperplasia of the terminal ileum can mimic active crohn disease on MR enterography. , 2014, AJR. American journal of roentgenology.

[25]  Z. Zeng,et al.  Systematic review with meta‐analysis: magnetic resonance enterography vs. computed tomography enterography for evaluating disease activity in small bowel Crohn's disease , 2014, Alimentary pharmacology & therapeutics.

[26]  A. Schoepfer,et al.  Prevalence and clinical importance of mesenteric venous thrombosis in the Swiss Inflammatory Bowel Disease Cohort. , 2014, AJR. American journal of roentgenology.

[27]  W. Bemelman,et al.  A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease , 2014, Gut.

[28]  S. Schmidt,et al.  Acute mesenteric vein thrombosis: factors associated with evolution to chronic mesenteric vein thrombosis. , 2014, AJR. American journal of roentgenology.

[29]  Cristina Lavini,et al.  Evaluation of conventional, dynamic contrast enhanced and diffusion weighted MRI for quantitative Crohn’s disease assessment with histopathology of surgical specimens , 2014, European Radiology.

[30]  I. Ordás,et al.  Accuracy of magnetic resonance enterography in assessing response to therapy and mucosal healing in patients with Crohn's disease. , 2014, Gastroenterology.

[31]  A. Forbes,et al.  Evaluation of Crohn’s disease activity: Initial validation of a magnetic resonance enterography global score (MEGS) against faecal calprotectin , 2014, European Radiology.

[32]  L. Boyer,et al.  Diffusion-Weighted Magnetic Resonance Imaging in Ileocolonic Crohn's Disease: Validation of Quantitative Index of Activity , 2014, The American Journal of Gastroenterology.

[33]  J. Fletcher,et al.  EMerging BiomARKers in Inflammatory Bowel Disease (EMBARK) Study Identifies Fecal Calprotectin, Serum MMP9, and Serum IL-22 as a Novel Combination of Biomarkers for Crohn's Disease Activity: Role of Cross-Sectional Imaging , 2013, The American Journal of Gastroenterology.

[34]  A. Forbes,et al.  Small bowel strictures in Crohn's disease: a quantitative investigation of intestinal motility using MR enterography , 2013, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[35]  Jaap Stoker,et al.  Grading Crohn disease activity with MRI: interobserver variability of MRI features, MRI scoring of severity, and correlation with Crohn disease endoscopic index of severity. , 2013, AJR. American journal of roentgenology.

[36]  D. Rubin,et al.  Mucosal Healing Is Associated with Improved Long-term Outcome of Maintenance Therapy with Natalizumab in Crohn's Disease , 2013, Inflammatory bowel diseases.

[37]  J. Dillman,et al.  Magnetic resonance imaging of perianal and perineal crohn disease in children and adolescents. , 2013, Magnetic resonance imaging clinics of North America.

[38]  R. Tutuian,et al.  MR imaging in Crohn's disease: correlation of MR motility measurement with histopathology in the terminal ileum , 2013, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[39]  S. Roberts,et al.  Diagnostic accuracy of high-resolution MR enterography in Crohn's disease: comparison with surgical and pathological specimen. , 2013, Clinical radiology.

[40]  Jeroen A. W. Tielbeek,et al.  Imaging techniques for assessment of inflammatory bowel disease: joint ECCO and ESGAR evidence-based consensus guidelines. , 2013, Journal of Crohn's & colitis.

[41]  I. Sakaida,et al.  Utility of Computed Tomographic Enteroclysis/Enterography for the Assessment of Mucosal Healing in Crohn's Disease , 2013, Gastroenterology research and practice.

[42]  F. Remzi,et al.  Crohn's disease complicated by strictures: a systematic review , 2013, Gut.

[43]  V. Petitcolin,et al.  Diffusion‐weighted magnetic resonance imaging for detecting and assessing ileal inflammation in Crohn's disease , 2013, Alimentary pharmacology & therapeutics.

[44]  Stuart A. Taylor,et al.  Assessment of wall inflammation and fibrosis in Crohn’s disease: value of T1-weighted gadolinium-enhanced MR imaging , 2012, Abdominal Imaging.

[45]  A. Zinsmeister,et al.  Endoscopic skipping of the distal terminal ileum in Crohn's disease can lead to negative results from ileocolonoscopy. , 2012, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[46]  Steve Halligan,et al.  Non-perforating small bowel Crohn's disease assessed by MRI enterography: derivation and histopathological validation of an MR-based activity index. , 2012, European journal of radiology.

[47]  D. Atkinson,et al.  Quantified terminal ileal motility during MR enterography as a potential biomarker of Crohn’s disease activity: a preliminary study , 2012, European Radiology.

[48]  F. Paparo,et al.  Crohn’s disease: prevalence of intestinal and extraintestinal manifestations detected by computed tomography enterography with water enema , 2012, Abdominal Imaging.

[49]  C. Saunders,et al.  Pediatric Crohn Disease Presenting as Appendicitis: Differentiating Features from Typical Appendicitis , 2012, European Journal of Pediatric Surgery.

[50]  F. Maccioni,et al.  Value of T2-weighted magnetic resonance imaging in the assessment of wall inflammation and fibrosis in Crohn’s disease , 2012, Abdominal Imaging.

[51]  J. Platt,et al.  Computed tomography enterography findings correlate with tissue inflammation, not fibrosis in resected small bowel Crohn's disease , 2012, Inflammatory bowel diseases.

[52]  J. Fletcher,et al.  Benefit of Computed Tomography Enterography in Crohn's Disease: Effects on Patient Management and Physician Level of Confidence§† , 2012, Inflammatory bowel diseases.

[53]  Jordi Rimola,et al.  Magnetic resonance imaging for evaluation of Crohn's disease: Validation of parameters of severity and quantitative index of activity , 2011, Inflammatory bowel diseases.

[54]  J. Fletcher,et al.  Computed tomography enterography detects intestinal wall changes and effects of treatment in patients with Crohn's disease. , 2011, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[55]  H. Hricak,et al.  Improving Communication of Diagnostic Radiology Findings through Structured Reporting 1 , 2011 .

[56]  Francesca Fornasa,et al.  Role of Magnetic Resonance Enterography in Differentiating between Fibrotic and Active Inflammatory Small Bowel Stenosis in Patients with Crohn's Disease , 2011, Journal of clinical imaging science.

[57]  David C Wilson,et al.  Pediatric modification of the Montreal classification for inflammatory bowel disease: The Paris classification , 2011, Inflammatory bowel diseases.

[58]  J. Fletcher,et al.  New concepts in intestinal imaging for inflammatory bowel diseases. , 2011, Gastroenterology.

[59]  L. Peyrin-Biroulet,et al.  Prospective comparison of computed tomography enterography and magnetic resonance enterography for assessment of disease activity and complications in ileocolonic Crohn's disease , 2011, Inflammatory bowel diseases.

[60]  Magaly Zappa,et al.  Which magnetic resonance imaging findings accurately evaluate inflammation in small bowel Crohn's disease? A retrospective comparison with surgical pathologic analysis , 2011, Inflammatory bowel diseases.

[61]  C. McCollough,et al.  Validation of a lower radiation computed tomography enterography imaging protocol to detect Crohn's disease in the small bowel , 2011, Inflammatory bowel diseases.

[62]  P. Marteau,et al.  Crohn’s disease: multi-detector row CT-enteroclysis appearance of the appendix , 2010, Abdominal Imaging.

[63]  H. Tilg,et al.  Development of the Crohn's disease digestive damage score, the Lémann score , 2010, Inflammatory bowel diseases.

[64]  Johannes M. Froehlich,et al.  MR motility imaging in Crohn’s disease improves lesion detection compared with standard MR imaging , 2010, European Radiology.

[65]  E. Vicaut,et al.  Suspected anastomotic recurrence of Crohn disease after ileocolic resection: evaluation with CT enteroclysis. , 2010, Radiology.

[66]  P. Rutgeerts,et al.  Mucosal healing predicts sustained clinical remission in patients with early-stage Crohn's disease. , 2010, Gastroenterology.

[67]  K. Whelan,et al.  Etiology of perianal Crohn's disease: Role of genetic, microbiological, and immunological factors , 2009, Inflammatory bowel diseases.

[68]  P. Rutgeerts,et al.  Mucosal healing predicts long‐term outcome of maintenance therapy with infliximab in Crohn's disease , 2009, Inflammatory bowel diseases.

[69]  Joel G. Fletcher,et al.  CT enterography and fistulizing Crohn’s disease: clinical benefit and radiographic findings , 2009, Abdominal Imaging.

[70]  Seong Ho Park,et al.  Crohn disease of the small bowel: comparison of CT enterography, MR enterography, and small-bowel follow-through as diagnostic techniques. , 2009, Radiology.

[71]  A. Horvath,et al.  Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. , 2009, Clinical chemistry.

[72]  Stuart A. Taylor,et al.  Mural inflammation in Crohn disease: location-matched histologic validation of MR imaging features. , 2009, Radiology.

[73]  A. Hara,et al.  Evaluation of colitis: usefulness of CT enterography technique , 2009, Emergency Radiology.

[74]  N. Obuchowski,et al.  Mural attenuation in normal small bowel and active inflammatory Crohn's disease on CT enterography: location, absolute attenuation, relative attenuation, and the effect of wall thickness. , 2009, AJR. American journal of roentgenology.

[75]  J. Fletcher,et al.  Prevalence of penetrating disease and extraintestinal manifestations of Crohn's disease detected with CT enterography , 2008, Inflammatory bowel diseases.

[76]  Joel G Fletcher,et al.  Small-bowel imaging in Crohn's disease: a prospective, blinded, 4-way comparison trial , 2008, Gastrointestinal endoscopy.

[77]  G. Guyatt,et al.  Going from evidence to recommendations , 2008, BMJ : British Medical Journal.

[78]  Gordon H Guyatt,et al.  GrADe : what is “ quality of evidence ” and why is it important to clinicians ? rATING quALITY of evIDeNCe AND STreNGTH of reCommeNDATIoNS , 2022 .

[79]  G. Guyatt,et al.  GRADE: an emerging consensus on rating quality of evidence and strength of recommendations , 2008, BMJ : British Medical Journal.

[80]  Roelof J Bennink,et al.  Magnetic resonance imaging in Crohn's disease , 2008 .

[81]  Cynthia S. Johnson,et al.  Correlation of CT Enteroclysis With Surgical Pathology in Crohn's Disease , 2007, The American Journal of Gastroenterology.

[82]  D. Einstein,et al.  CT Enterography for Crohn’s Disease: Accurate Preoperative Diagnostic Imaging , 2007, Diseases of the colon and rectum.

[83]  J. Platt,et al.  Computed tomographic enterography adds information to clinical management in small bowel Crohn's disease , 2007, Inflammatory bowel diseases.

[84]  Joel Garland Fletcher,et al.  Quantitative measurement and visual assessment of ileal Crohn’s disease activity by computed tomography enterography: correlation with endoscopic severity and C reactive protein , 2006, Gut.

[85]  Joel G Fletcher,et al.  Crohn Disease: mural attenuation and thickness at contrast-enhanced CT Enterography--correlation with endoscopic and histologic findings of inflammation. , 2006, Radiology.

[86]  J. Satsangi,et al.  Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. , 2005, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

[87]  B. Bonaz,et al.  Small Bowel Adenocarcinoma in Patients with Crohn's Disease Compared with Small Bowel Adenocarcinoma De Novo , 2005, Inflammatory bowel diseases.

[88]  A. Fichera,et al.  Superior Mesenteric Vein Thrombosis After Colectomy for Inflammatory Bowel Disease , 2003, Diseases of the colon and rectum.

[89]  F. Carbonnel,et al.  Long-Term Evolution of Disease Behavior of Crohn's Disease , 2002, Inflammatory bowel diseases.

[90]  A. Zinsmeister,et al.  A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn's perianal fistulas. , 2001, Gastroenterology.

[91]  M. Macari,et al.  CT of bowel wall thickening: significance and pitfalls of interpretation. , 2001, AJR. American journal of roentgenology.

[92]  C. Gasche,et al.  Significant association of strictures and internal fistula formation in Crohn’s disease , 2000, Virchows Archiv.

[93]  J. Morris,et al.  MR imaging classification of perianal fistulas and its implications for patient management. , 2000, Radiographics : a review publication of the Radiological Society of North America, Inc.

[94]  D. Wilson,et al.  Outcome after surgery for perianal fistula: predictive value of MR imaging. , 1998, AJR. American journal of roentgenology.

[95]  M. A. Meyers,et al.  Spiral CT demonstration of hypervascularity in Crohn disease: “vascular jejunization of the ileum” or the “comb sign” , 1995, Abdominal Imaging.

[96]  R. Preshaw,et al.  Origin of Fistulas in Crohn's Disease , 1989, Journal of clinical gastroenterology.

[97]  P. gordon,et al.  A classification of fistula‐in‐ano , 1976 .

[98]  Diego R. Martín,et al.  ACR–SAR–SPR PRACTICE PARAMETER FOR THE PERFORMANCE OF MAGNETIC RESONANCE (MR) ENTEROGRAPHY , 2015 .

[99]  E. Louis,et al.  Development of the Lémann index to assess digestive tract damage in patients with Crohn's disease. , 2015, Gastroenterology.

[100]  J. Dillman,et al.  Pediatric MR enterography: technique and approach to interpretation-how we do it. , 2015, Radiology.

[101]  別府 孝浩 Mucosal healing of ileal lesions is associated with long-term clinical remission after infliximab maintenance treatment in patients with Crohn's disease , 2014 .

[102]  Elliot K Fishman,et al.  Pancreatic ductal adenocarcinoma radiology reporting template: consensus statement of the Society of Abdominal Radiology and the American Pancreatic Association. , 2014, Radiology.

[103]  L. Peyrin-Biroulet,et al.  Preoperative Magnetic Resonance Enterography in Predicting Findings and Optimizing Surgical Approach in Crohn's Disease , 2013, Journal of Gastrointestinal Surgery.

[104]  D. Hoyo,et al.  MR imaging evaluation of perianal fistulas: spectrum of imaging features. , 2012, Radiographics : a review publication of the Radiological Society of North America, Inc.

[105]  Diego R. Martín,et al.  Magnetic resonance enterography in Crohn's disease: techniques, interpretation, and utilization for clinical management. , 2012, Diagnostic and interventional radiology.

[106]  M. Picco,et al.  Magnetic resonance for assessment of disease activity and severity in ileocolonic Crohn's disease , 2010 .

[107]  J. Dillman,et al.  CT enterography of pediatric Crohn disease , 2009, Pediatric Radiology.

[108]  J. V. van Engelshoven,et al.  Preoperative MR imaging of anal fistulas: Does it really help the surgeon? , 2001, Radiology.

[109]  J. Lee,et al.  Small-bowel disease: categorization by CT examination. , 1987, AJR. American journal of roentgenology.