Automatic Melanoma Detection Using Multi- Stage Neural Networks

Skin cancer accounts for more than half of all cancers detected in USA every year. Melanoma is less common, but more aggressive and hence more dangerous than the other types of skin cancers. Even though there has been extensive research in the past 20 years on automatic melanoma detection from skin lesion images, most of the dermatologists still do not have access to this technology. In this paper, a novel system is proposed. The system uses enhanced image processing to segment the images without manual intervention. From the segmented image, it extracts a comprehensive set of features using new and improved techniques. The features were fed automatically to a multistage neural network classifier which achieved greater than 97% sensitivity and greater than 93% specificity. The trained system was tested with lesion images found online and it was able to achieve similar sensitivity. Finally, a new approach that will simplify the entire diagnosis process is discussed. This approach uses Dermlite® DL1 dermatoscope that can be attached to the iPhone. After taking the lesion image with a dermatoscope attached iPhone, the physician gets the diagnosis with a few simple clicks. This system could have widespread ramifications on melanoma diagnosis. It achieves higher sensitivity than previous research and provides an easy to use iPhone based app to detect melanoma in early stages without the need for biopsy.

[1]  Khobaib Zaamout,et al.  Improving Neural Networks Classification through Chaining , 2012, ICANN.

[2]  R. H. Moss,et al.  Neural network diagnosis of malignant melanoma from color images , 1994, IEEE Transactions on Biomedical Engineering.

[3]  John F. Canny,et al.  A Computational Approach to Edge Detection , 1986, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[4]  Robert B. Fisher,et al.  Non-melanoma skin lesion classification using colour image data in a hierarchical K-NN classifier , 2012, 2012 9th IEEE International Symposium on Biomedical Imaging (ISBI).

[5]  W. Hargrove,et al.  Lacunarity analysis: A general technique for the analysis of spatial patterns. , 1996, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[6]  David Polsky,et al.  Early diagnosis of cutaneous melanoma: revisiting the ABCD criteria. , 2004, JAMA.

[7]  L. K. Hansen,et al.  Melanoma diagnosis by Raman spectroscopy and neural networks: structure alterations in proteins and lipids in intact cancer tissue. , 2004, The Journal of investigative dermatology.

[8]  John D. Austin,et al.  Adaptive histogram equalization and its variations , 1987 .

[9]  R. H. Moss,et al.  A fuzzy-based histogram analysis technique for skin lesion discrimination in dermatology clinical images. , 2003, Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society.

[10]  J. Abdul Jaleel,et al.  Artificial Neural Network Based Detection of Skin Cancer , 2012 .

[11]  Paul F. Whelan,et al.  Integration of Colour and Texture Distributions for Skin Cancer Image Segmentation , 2010 .

[12]  M. Pietikäinen,et al.  TEXTURE ANALYSIS WITH LOCAL BINARY PATTERNS , 2004 .

[13]  Heekuck Oh,et al.  Neural Networks for Pattern Recognition , 1993, Adv. Comput..

[14]  Fatos T. Yarman-Vural,et al.  On the Performance of Stacked Generalization Classifiers , 2008, ICIAR.

[15]  N. Otsu A threshold selection method from gray level histograms , 1979 .

[16]  W V Stoecker,et al.  Automatic detection of asymmetry in skin tumors. , 1992, Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society.

[17]  A. Kopf,et al.  Early detection of malignant melanoma: The role of physician examination and self‐examination of the skin , 1985, CA: a cancer journal for clinicians.

[18]  T Lee,et al.  Dullrazor®: A software approach to hair removal from images , 1997, Comput. Biol. Medicine.

[19]  R. H. Moss,et al.  Colour analysis of skin lesion regions for melanoma discrimination in clinical images , 2003, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[20]  Javier Ruiz-del-Solar,et al.  Skin detection using neighborhood information , 2004, Sixth IEEE International Conference on Automatic Face and Gesture Recognition, 2004. Proceedings..

[21]  Randy H. Moss,et al.  Advances in skin cancer image analysis , 2011, Comput. Medical Imaging Graph..

[22]  J. Wolf,et al.  Diagnostic inaccuracy of smartphone applications for melanoma detection. , 2013, JAMA dermatology.

[23]  J. A. Hartigan,et al.  A k-means clustering algorithm , 1979 .

[24]  R. Hofmann-Wellenhof,et al.  Lacunarity Analysis: A Promising Method for the Automated Assessment of Melanocytic Naevi and Melanoma , 2009, PloS one.

[25]  Heng Tao Shen,et al.  Principal Component Analysis , 2009, Encyclopedia of Biometrics.

[26]  David I. McLean,et al.  Irregularity index: A new border irregularity measure for cutaneous melanocytic lesions , 2003, Medical Image Anal..