Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes

[1]  L. Groop,et al.  CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion , 2016, Diabetologia.

[2]  L. Eliasson,et al.  Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells , 2016, PloS one.

[3]  J. Schug,et al.  Islet-1 Is Essential for Pancreatic β-Cell Function , 2014, Diabetes.

[4]  L. Groop,et al.  Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism , 2014, Proceedings of the National Academy of Sciences.

[5]  Nikhil R. Gandasi,et al.  Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site , 2014, Nature Communications.

[6]  L. Groop,et al.  TCF7L2 is a master regulator of insulin production and processing , 2014, bioRxiv.

[7]  L. Eliasson The exocytotic machinery , 2014, Acta physiologica.

[8]  F. Ashcroft,et al.  KATP channels and islet hormone secretion: new insights and controversies , 2013, Nature Reviews Endocrinology.

[9]  M. Sander,et al.  Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. , 2013, Cell reports.

[10]  E. Gilbert,et al.  Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes. , 2012, Current diabetes reviews.

[11]  B. Olde,et al.  Cocaine- and Amphetamine-regulated Transcript (CART) Protects Beta Cells against Glucotoxicity and Increases Cell Proliferation* , 2012, The Journal of Biological Chemistry.

[12]  L. Groop,et al.  Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes , 2012, Molecular and Cellular Endocrinology.

[13]  A. Wiederkehr,et al.  Mitochondrial signals drive insulin secretion in the pancreatic β-cell , 2012, Molecular and Cellular Endocrinology.

[14]  P. O S I T I O N S T A T E M E N T,et al.  Diagnosis and Classification of Diabetes Mellitus , 2011, Diabetes Care.

[15]  D. Steiner,et al.  A brief perspective on insulin production , 2009, Diabetes, obesity & metabolism.

[16]  L. Eliasson,et al.  Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells. , 2009, American journal of physiology. Endocrinology and metabolism.

[17]  M. Kuhar,et al.  CART peptides: regulators of body weight, reward and other functions , 2008, Nature Reviews Neuroscience.

[18]  P. Meda,et al.  Munc 18‐1 and Granuphilin Collaborate During Insulin Granule Exocytosis , 2008, Traffic.

[19]  C. Newgard,et al.  Stimulation of Human and Rat Islet β-Cell Proliferation with Retention of Function by the Homeodomain Transcription Factor Nkx6.1 , 2008, Molecular and Cellular Biology.

[20]  T. Südhof,et al.  Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice , 2008, Proceedings of the National Academy of Sciences.

[21]  P. Marchetti,et al.  An overview of pancreatic beta-cell defects in human type 2 diabetes: Implications for treatment , 2008, Regulatory Peptides.

[22]  Sufang Yang,et al.  Mitochondrial mechanism of neuroprotection by CART , 2007, The European journal of neuroscience.

[23]  L. Sussel,et al.  Nkx2.2 Regulates β-Cell Function in the Mature Islet , 2007, Diabetes.

[24]  Bo Ahrén,et al.  Neuropeptides and the Regulation of Islet Function , 2006, Diabetes.

[25]  M. Cerf,et al.  Transcription factors regulating β-cell function , 2006 .

[26]  F. Sundler,et al.  CART is a novel islet regulatory peptide , 2006, Peptides.

[27]  A. Lakatos,et al.  The CART receptors: Background and recent advances , 2006, Peptides.

[28]  L. Eliasson,et al.  Antibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells. , 2006, Journal of molecular endocrinology.

[29]  W. Richards,et al.  CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight , 2005, Regulatory Peptides.

[30]  J. D. Engel,et al.  MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion , 2005, Molecular and Cellular Biology.

[31]  P. Rorsman,et al.  Palmitate increases L‐type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic β‐cells , 2004, The Journal of physiology.

[32]  A. Mari,et al.  Beta cell function and its relation to insulin action in humans: a critical appraisal , 2004, Diabetologia.

[33]  M. Kuhar,et al.  Cocaine‐ and amphetamine‐regulated transcript: distribution and function in rat gastrointestinal tract , 2003, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[34]  B. Wicksteed,et al.  Insulin Secretory Deficiency and Glucose Intolerance in Rab3A Null Mice* , 2003, The Journal of Biological Chemistry.

[35]  S. Kahn,et al.  The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes , 2003, Diabetologia.

[36]  D. Piston,et al.  Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion* , 2002, The Journal of Biological Chemistry.

[37]  M. Tsai,et al.  Neogenesis of β-cells in adult BETA2/NeuroD-deficient mice , 2002 .

[38]  E. Cerasi,et al.  Regulation of insulin gene transcription , 2002, Diabetologia.

[39]  L. Sussel,et al.  Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. , 2000, Development.

[40]  M. Prentki,et al.  Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. , 2000, Diabetes.

[41]  D. Leshkowitz,et al.  Transcription Factor BETA2 Acts Cooperatively with E2A and PDX1 to Activate the Insulin Gene Promoter* , 2000, The Journal of Biological Chemistry.

[42]  G. Baldini,et al.  Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells. , 1999, Molecular endocrinology.

[43]  Y. Smith,et al.  CART peptides in the central control of feeding and interactions with neuropeptide Y , 1998, Synapse.

[44]  M S German,et al.  Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. , 1998, Development.

[45]  H. Edlund,et al.  beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. , 1998, Genes & development.

[46]  D R Hadden,et al.  Beta‐cell deterioration determines the onset and rate of progression of secondary dietary failure in Type 2 diabetes mellitus: the 10‐year follow‐up of the Belfast Diet Study , 1998, Diabetic medicine : a journal of the British Diabetic Association.

[47]  L. Eliasson,et al.  Rapid ATP‐Dependent Priming of Secretory Granules Precedes Ca2+ ‐Induced Exocytosis in Mouse Pancreatic B‐Cells , 1997, The Journal of physiology.

[48]  C. Wollheim,et al.  Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells. , 1996, Journal of cell science.

[49]  E. Neher,et al.  Protein Kinase C Enhances Exocytosis from Chromaffin Cells by Increasing the Size of the Readily Releasable Pool of Secretory Granules , 1996, Neuron.

[50]  H. Edlund,et al.  Insulin-promoter-factor 1 is required for pancreas development in mice , 1994, Nature.

[51]  L. Orci,et al.  Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump. , 1987, The Journal of biological chemistry.

[52]  Richard G. W. Anderson,et al.  Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles , 1987, Cell.

[53]  M. Kuhar,et al.  Cart Regulates Islet Hormone Secretion and Is Expressed in the ␤-cells of Type 2 Diabetic Rats Research Design and Methods , 2005 .

[54]  M. Tsai,et al.  BETA2 and pancreatic islet development. , 2001, Recent progress in hormone research.