Hybrid optoacoustic and ultrasonic imaging system for detection of prostate malignancies

Ultrasound imaging is the current gold standard for guiding biopsy of prostate. Optoacoustic imaging yields higher contrast in detection of malignant tissues. The two techniques provide complementary information. We are currently developing a hybrid laser optoacoustic and ultrasound imaging system for prostate tumor detection (LOUIS-P). The optoacoustic part consists of a fiber-coupled Q-switched laser operating at either 757 nm or 1064 nm attached to a commercially-available 128-channel ultrasonic probe modified for optimal detection of optoacoustic signals, a digital signal processor with 128 independent channels, and software that uses the radial (filtered) backprojection algorithm to reconstruct tomographic images. We evaluated system-imaging performance using test objects submerged in milky water, and poly(vinyl-chloride) plastisol tissue phantoms simulating malignant lesions. LOUIS-P demonstrates potential as a clinical technique for minimally invasive imaging and diagnosis of prostate cancer.

[1]  Greg Schaefer,et al.  Angiogenesis in Prostate Cancer: Biology and Therapeutic Opportunities , 2004, Cancer and Metastasis Reviews.

[2]  M. Blake,et al.  Predictors of prostate carcinoma: accuracy of gray-scale and color Doppler US and serum markers. , 2001, Radiology.

[3]  Georg Bartsch,et al.  Cancer of the prostate. , 2005, Critical reviews in oncology/hematology.

[4]  E. Ulusoy,et al.  Relationship between prostate specific antigen density, microvessel density and prostatic volume in benign prostatic hyperplasia and advanced prostatic carcinoma , 2006, International Urology and Nephrology.

[5]  K. Ezz El Din,et al.  Transrectal ultrasonography of the prostate , 1996 .

[6]  Jarod C Finlay,et al.  Determination of the distribution of light, optical properties, drug concentration, and tissue oxygenation in-vivo in human prostate during motexafin lutetium-mediated photodynamic therapy. , 2005, Journal of photochemistry and photobiology. B, Biology.

[7]  H. Wijkstra,et al.  Transrectal contrast enhanced ultrasound for diagnosis of prostate cancer , 2007, World Journal of Urology.

[8]  Alexander A Karabutov,et al.  Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics. , 2007, Applied optics.

[9]  Jan Laufer,et al.  Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration , 2007, Physics in medicine and biology.

[10]  P. Sooriakumaran,et al.  Angiogenesis and the tumour hypoxia response in prostate cancer: a review. , 2005, International journal of surgery.

[11]  J. Brown,et al.  Exploiting tumour hypoxia in cancer treatment , 2004, Nature Reviews Cancer.

[12]  Kathleen N. Lohr,et al.  Screening for Prostate Cancer: An Update of the Evidence , 2002 .

[13]  Peter L Choyke,et al.  Imaging prostate cancer: a multidisciplinary perspective. , 2007, Radiology.

[14]  R J Roselli,et al.  Measurement of thermal effects on the optical properties of prostate tissue at wavelengths of 1,064 and 633 nm , 1999, Lasers in surgery and medicine.

[15]  Martina Meinke,et al.  Optical properties of platelets and blood plasma and their influence on the optical behavior of whole blood in the visible to near infrared wavelength range. , 2007, Journal of biomedical optics.

[16]  Wendy L. Smith,et al.  Prostate volume contouring: a 3D analysis of segmentation using 3DTRUS, CT, and MR. , 2007, International journal of radiation oncology, biology, physics.

[17]  A. Oraevsky,et al.  Detection of ultrawide-band ultrasound pulses in optoacoustic tomography , 2003, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[18]  Kathleen N Lohr,et al.  Screening for Prostate Cancer: An Update of the Evidence for the U.S. Preventive Services Task Force , 2002, Annals of Internal Medicine.

[19]  T. Loch,et al.  Urologic imaging for localized prostate cancer in 2007 , 2007, World Journal of Urology.

[20]  Ketan Mehta,et al.  128-channel laser optoacoustic imaging system (LOIS-128) for breast cancer diagnostics , 2006, SPIE BiOS.

[21]  L Wang,et al.  MCML--Monte Carlo modeling of light transport in multi-layered tissues. , 1995, Computer methods and programs in biomedicine.

[22]  Timothy C. Zhu,et al.  Optical Properties of Human Prostate at 732 nm Measured In Vivo During Motexafin Lutetium–mediated Photodynamic Therapy¶ , 2005 .

[23]  R. Esenaliev,et al.  Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors , 1999 .

[24]  Wiendelt Steenbergen,et al.  Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms. , 2004, Journal of biomedical optics.

[25]  Wiendelt Steenbergen,et al.  The Twente Photoacoustic Mammoscope: system overview and performance , 2005, Physics in medicine and biology.

[26]  K. Svanberg,et al.  In vivo optical characterization of human prostate tissue using near-infrared time-resolved spectroscopy. , 2007, Journal of biomedical optics.

[27]  André Conjusteau,et al.  Detection and noninvasive diagnostics of breast cancer with 2-color laser optoacoustic imaging system , 2007, SPIE BiOS.

[28]  M R Arnfield,et al.  OPTICAL PROPERTIES OF EXPERIMENTAL PROSTATE TUMORS in vivo , 1993, Photochemistry and photobiology.

[29]  Ketan Mehta,et al.  Development and testing of an optoacoustic imaging system for monitoring and guiding prostate cancer therapies , 2004, SPIE BiOS.

[30]  I Mehdi,et al.  Early detection of prostate cancer. , 1998, JPMA. The Journal of the Pakistan Medical Association.

[31]  Alexander A. Oraevsky,et al.  Two-dimensional optoacoustic tomography: transducer array and image reconstruction algorithm , 1999, Photonics West - Biomedical Optics.

[32]  M. Mason,et al.  Cancer of the prostate , 2003 .

[33]  Ketan Mehta,et al.  In vivo testing of laser optoacoustic system for image-guided biopsy of prostate , 2006, SPIE BiOS.

[34]  Transrectal Ultrasound of the Prostate: Innovations and Future Applications , 1998 .

[35]  D. Ransohoff,et al.  Early detection of prostate cancer. Serendipity strikes again. , 1997, JAMA.

[36]  Shahin Rafii,et al.  Role of Angiogenesis in the Progression and Treatment of Prostate Cancer , 2001, Cancer investigation.

[37]  Martin Frenz,et al.  Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo , 2005, IEEE Transactions on Medical Imaging.

[38]  Hans Lilja,et al.  Circulating biomarkers for prostate cancer , 2007, World Journal of Urology.

[39]  U. P. S. T. Force,et al.  Screening for Prostate Cancer: Recommendation and Rationale , 2002, Annals of Internal Medicine.