The Protective Role of Transplanted Bone Marrow Cells against Injuries Induced by a Chemical Carcinogen and / or γ-Rays in Kidney tissue of Rats.

Aim of the work:this work aimed to study the biochemical and histopathological changes in the kidney of male albino rats post exposure to 6Gy of gamma radiation and the protective role of transplanted bone marrow cellsagainst damage induced in rat's kidney by a chemical carcinogen. Materials and Methods: in this study, forty eight healthy and active male albino rats about 120 grams in body weight were used. The animals were housed in plastic cages under normal temperature, pressure, humidity and good ventilation conditions during the whole period of experimentation. The animals were fed on a standard pellet diet and water. Results:exposure of rats to γ-radiation caused a significant increase in kidney function tests, decreased significantly the antioxidants with numerous histopathological changes in the rat kidney tissue. These changes were ameliorated by bone marrow transplantation either after whole body gamma-irradiation and/or Fe-NTA treatment. Conclusion: bone marrow transplantation either after whole body gamma-irradiation and/or Fe-NTA treatment restored the kidney functions and ameliorated the oxidative stress and antioxidants markers.  The histopathological observations showed amelioration in the structure of the kidney cortex. So, BM transplantation exerts some curative effects on the function and histological structure of kidney cortex of rats exposed to gamma-irradiation and/or Fe-NTA treatment.