In the present investigation, after hatching the randomly selected 42 birds were divided into 7 groups and reared under open range system. The seven groups of birds were kept for different periods i.e. day old, 2 weeks, 4weeks, 8weeks, 20weeks, 30weeks and 40 weeks. Blood samples about 23 ml were collected from the wing veins of each bird under aseptic condition by using insulin syringe. After blood collection the birds were slaughtered for histological works. From the study it as observed that Alkaline phosphatase decreased significantly with age i.e. for 0 to 40 weeks while AST, ALT, CPK, glucose, protein, cholesterol, creatinine and triglycerides increased significantly (P<0.0001) with age. The microscopic structure of thyroid glands of Pati ducks revealed primarily the capsule enclosing the follicles that contained colloid. Parafollicular cells were found in interfollicular space.
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