Coordination of grip and load forces during vertical point-to-point movements with a grasped object in Parkinson's disease.

Thirteen patients with Parkinson's disease and 13 age-matched control subjects performed vertical point-to-point arm movements with an instrumented object, starting and ending with the object being held stationary. All Parkinsonian patients were tested on medication. Parkinsonian patients retained all aspects of predictive grip force control. Compared with healthy controls, they generated similar static grip forces during stationary holding and similar force ratios between maximum grip and load force, reflecting effective grip force adjustments in relation to movement-induced inertial loads. Grip and load force maximums coincided very closely, indicating that temporal aspects of predictive grip force regulation were also unaffected. However, Parkinsonian subjects showed additional oscillations in acceleration and grip force due to tremor and produced significantly slower arm accelerations due to bradykinesia. The results suggest that Parkinson's disease does not significantly impair the anticipation of movement-induced load fluctuations during voluntary arm movements with a grasped object performed on medication.

[1]  M Wiesendanger,et al.  Recent developments in studies of the supplementary motor area of primates. , 1986, Reviews of physiology, biochemistry and pharmacology.

[2]  K. Flowers.  Visual "closed-loop" and "open-loop" characteristics of voluntary movement in patients with Parkinsonism and intention tremor. , 1976, Brain : a journal of neurology.

[3]  H. Forssberg,et al.  Anticipatory Control of Manipulative Forces in Parkinson's Disease , 1997, Experimental Neurology.

[4]  D. Brooks.  Imaging basal ganglia function , 2000, Journal of anatomy.

[5]  L. Tremblay,et al.  Abnormal influences of passive limb movement on the activity of globus pallidus neurons in parkinsonian monkeys , 1988, Brain Research.

[6]  C. Marsden,et al.  Disturbance of sequential movements in patients with Parkinson's disease. , 1987, Brain : a journal of neurology.

[7]  R. Schwab,et al.  Action tremor and the cogwheel phenomenon in Parkinson's disease. , 1963, Brain : a journal of neurology.

[8]  M. Delong,et al.  Pathophysiology of parkinsonian motor abnormalities. , 1993, Advances in neurology.

[9]  P. Strick,et al.  The Organization of Cerebellar and Basal Ganglia Outputs to Primary Motor Cortex as Revealed by Retrograde Transneuronal Transport of Herpes Simplex Virus Type 1 , 1999, The Journal of Neuroscience.

[10]  A. M. Smith,et al.  Primary motor cortical activity related to the weight and texture of grasped objects in the monkey. , 1992, Journal of neurophysiology.

[11]  M L Latash,et al.  Feedforward postural adjustments in a simple two-joint synergy in patients with Parkinson's disease. , 1995, Electroencephalography and clinical neurophysiology.

[12]  P. Roland,et al.  Supplementary motor area and other cortical areas in organization of voluntary movements in man. , 1980, Journal of neurophysiology.

[13]  José Luis Contreras-Vidal,et al.  A neural model of basal ganglia-thalamocortical relations in normal and parkinsonian movement , 1995, Biological Cybernetics.

[14]  P. Strick,et al.  Basal Ganglia Output and Cognition: Evidence from Anatomical, Behavioral, and Clinical Studies , 2000, Brain and Cognition.

[15]  D M Wolpert,et al.  Predicting the Consequences of Our Own Actions: The Role of Sensorimotor Context Estimation , 1998, The Journal of Neuroscience.

[16]  H. Forssberg,et al.  Coordination of Manipulative Forces in Parkinson's Disease , 1997, Experimental Neurology.

[17]  R. Johansson,et al.  Nondigital afferent input in reactive control of fingertip forces during precision grip , 1996, Experimental Brain Research.

[18]  A. M. Smith,et al.  Purkinje cell simple spike activity during grasping and lifting objects of different textures and weights. , 1990, Journal of neurophysiology.

[19]  E. Montgomery,et al.  The movement speed/accuracy operator in Parkinson's disease , 1990, Neurology.

[20]  C. Marsden,et al.  Slowness of movement in Parkinson's disease , 1989, Movement disorders : official journal of the Movement Disorder Society.

[21]  J Jacquy,et al.  Parkinsonian bradykinesia is due to depression in the rate of rise of muscle activity , 1992, Annals of neurology.

[22]  A. M. Smith,et al.  Friction, not texture, dictates grip forces used during object manipulation. , 1996, Journal of neurophysiology.

[23]  A. Gordon.  Object release in patients with Parkinson's disease , 1997, Neuroscience Letters.

[24]  H J Sagar,et al.  A component analysis of the generation and release of isometric force in Parkinson's disease. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[25]  J. Flanagan,et al.  The stability of precision grip forces during cyclic arm movements with a hand-held load , 1990, Experimental Brain Research.

[26]  R. Johansson,et al.  Action tremor during object manipulation in Parkinson's disease , 2000, Movement disorders : official journal of the Movement Disorder Society.

[27]  S Glasauer,et al.  The effects of digital anaesthesia on predictive grip force adjustments during vertical movements of a grasped object , 2001, The European journal of neuroscience.

[28]  N Accornero,et al.  Sequential arm movements in patients with Parkinson's disease, Huntington's disease and dystonia. , 1992, Brain : a journal of neurology.

[29]  R. Johansson,et al.  Somatosensory control of precision grip during unpredictable pulling loads , 1992, Experimental Brain Research.

[30]  J H Abbs,et al.  Precision grip in parkinsonian patients. , 1990, Advances in neurology.

[31]  C. David Marsden,et al.  Motor disturbances 1 , 1987 .

[32]  J R Flanagan,et al.  The Role of Internal Models in Motion Planning and Control: Evidence from Grip Force Adjustments during Movements of Hand-Held Loads , 1997, The Journal of Neuroscience.

[33]  N. Accornero,et al.  Performance of sequential arm movements with and without advance knowledge of motor pathways in Parkinson's disease , 1997, Movement disorders : official journal of the Movement Disorder Society.

[34]  K. Nakano.  Neural circuits and topographic organization of the basal ganglia and related regions , 2000, Brain and Development.

[35]  R. S. Johansson,et al.  Roles of glabrous skin receptors and sensorimotor memory in automatic control of precision grip when lifting rougher or more slippery objects , 2004, Experimental Brain Research.

[36]  A. Wing,et al.  Impaired anticipatory finger grip-force adjustments in a case of cerebellar degeneration , 1999, Experimental Brain Research.

[37]  R. Iansek,et al.  The role of the supplementary motor area in the control of voluntary movement , 1996 .

[38]  J. Flanagan,et al.  Coupling of grip force and load force during arm movements with grasped objects , 1993, Neuroscience Letters.

[39]  C. Markham,et al.  Parkinson's disease , 1987, Neurology.

[40]  R. Johansson,et al.  Coordinated isometric muscle commands adequately and erroneously programmed for the weight during lifting task with precision grip , 2004, Experimental Brain Research.

[41]  M. Aminoff,et al.  Sensory perception in Parkinson disease. , 1997, Archives of neurology.

[42]  G. Goldberg.  Supplementary motor area structure and function: Review and hypotheses , 1985, Behavioral and Brain Sciences.

[43]  D. Humphrey,et al.  Motor control : concepts and issues , 1991 .

[44]  M. Hepp-Reymond,et al.  Sensorimotor cortical control of isometric force in the monkey. , 1989, Progress in brain research.

[45]  C. Marsden,et al.  Performance of simultaneous movements in patients with Parkinson's disease. , 1986, Brain : a journal of neurology.

[46]  J. Flanagan,et al.  Modulation of grip force with load force during point-to-point arm movements , 2004, Experimental Brain Research.

[47]  Roland S. Johansson,et al.  Sensory Control of Dexterous Manipulation in Humans , 1996 .

[48]  C. Marsden,et al.  Recent Developments in Parkinson's Disease , 1986 .

[49]  Roland S. Johansson,et al.  Somatosensory control of precision grip during unpredictable pulling loads , 2004, Experimental Brain Research.

[50]  Hiroshi Kinoshita,et al.  Functional brain areas used for the lifting of objects using a precision grip: a PET study , 2000, Brain Research.

[51]  N. Accornero,et al.  Fast complex arm movements in Parkinson's disease. , 1986, Journal of neurology, neurosurgery, and psychiatry.