Small molecule screening by imaging.
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[1] Norbert Perrimon,et al. Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets , 2004, PLoS biology.
[2] Stuart L Schreiber,et al. Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation , 2004, Nature Biotechnology.
[3] Daniel Rauh,et al. An Unbiased Cell Morphology–Based Screen for New, Biologically Active Small Molecules , 2005, PLoS biology.
[4] Douglas A. Creager,et al. The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging , 2005, Genome Biology.
[5] Young-Tae Chang,et al. Dissection of melanogenesis with small molecules identifies prohibitin as a regulator. , 2005, Chemistry & biology.
[6] Marc Vidal,et al. Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis , 2005, Nature.
[7] Timothy J Mitchison,et al. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. , 2005, Chemistry & biology.
[8] Wolfgang Rottbauer,et al. High-throughput assay for small molecules that modulate zebrafish embryonic heart rate , 2005, Nature chemical biology.
[9] Sebastian A. Leidel,et al. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III , 2000, Nature.
[10] L. Zon,et al. In vivo drug discovery in the zebrafish , 2005, Nature Reviews Drug Discovery.
[11] Pamela A. Silver,et al. A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. , 2003, Cancer cell.
[12] Lani F. Wu,et al. Multidimensional Drug Profiling By Automated Microscopy , 2004, Science.
[13] Norbert Perrimon,et al. Genome-wide high-throughput screens in functional genomics. , 2004, Current opinion in genetics & development.
[14] B. Stockwell,et al. Biological mechanism profiling using an annotated compound library. , 2003, Chemistry & biology.
[15] Mark Stamnes,et al. Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro , 2006, Nature chemical biology.
[16] Tae-Wook Kang,et al. A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening. , 2002, Journal of the American Chemical Society.
[17] Brent R Stockwell,et al. Advances in chemical genetics. , 2005, Annual review of genomics and human genetics.
[18] Yann LeCun,et al. Toward automatic phenotyping of developing embryos from videos , 2005, IEEE Transactions on Image Processing.
[19] Randall W King,et al. Small molecules that delay S phase suppress a zebrafish bmyb mutant , 2005, Nature chemical biology.
[20] Robert F Murphy,et al. From quantitative microscopy to automated image understanding. , 2004, Journal of biomedical optics.
[21] Petra Ross-Macdonald,et al. Model systems in drug discovery: chemical genetics meets genomics. , 2003, Pharmacology & therapeutics.
[22] Timothy J Mitchison,et al. A Novel Action of Histone Deacetylase Inhibitors in a Protein Aggresome Disease Model , 2004, Current Biology.
[23] J. Dowling,et al. Small molecule developmental screens reveal the logic and timing of vertebrate development. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[24] D. L. Taylor,et al. High content screening applied to large-scale cell biology. , 2004, Trends in biotechnology.
[25] Timothy J Mitchison,et al. High‐Content Screening and Profiling of Drug Activity in an Automated Centrosome‐Duplication Assay , 2005, Chembiochem : a European journal of chemical biology.
[26] P. Zipperlen,et al. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference , 2000, Nature.
[27] T. Mitchison,et al. Phenotypic screening of small molecule libraries by high throughput cell imaging. , 2003, Combinatorial chemistry & high throughput screening.
[28] P. Schultz,et al. Identification of a novel protein regulating microtubule stability through a chemical approach. , 2004, Chemistry & biology.
[29] T. Mitchison,et al. Small molecules in an RNAi world. , 2006, Molecular bioSystems.
[30] David R Spring,et al. Chemical genetics to chemical genomics: small molecules offer big insights. , 2005, Chemical Society reviews.
[31] A. Coulson,et al. Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans , 2005, Nature.
[32] D. Botstein,et al. Cluster analysis and display of genome-wide expression patterns. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[33] Erik Brauner,et al. Informatics and Quantitative Analysis in Biological Imaging , 2003, Science.
[34] Timothy J Mitchison,et al. Small‐Molecule Screening and Profiling by Using Automated Microscopy , 2005, Chembiochem : a European journal of chemical biology.
[35] Peter Wipf,et al. Cell-active dual specificity phosphatase inhibitors identified by high-content screening. , 2003, Chemistry & biology.