A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor

This report describes an avian TCR molecule, TCR1, whose molecular characteristics, signal-transducing property, and tissue distribution suggest that it is a homologue of the mammalian TCR-gamma/delta. TCR1+ cells are the first to be generated in the thymus during ontogeny, preceding other T3+ cells by approximately 3 d. Unlike their mammalian counterpart, TCR1+ cells constitute a relatively large subpopulation of peripheral T cells in mature chickens. These results suggest a phylogenetically important role for this receptor in T cell development and function.

[1]  P. Marrack,et al.  T cell tolerance by clonal elimination in the thymus , 1987, Cell.

[2]  N. Federspiel,et al.  The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer , 1987, The Journal of experimental medicine.

[3]  J. Bluestone,et al.  Characterization of murine thymocytes with CDS-associated T-cell receptor structures , 1987, Nature.

[4]  J. Coligan,et al.  Differential expression of two distinct T-cell receptors during thymocyte development , 1987, Nature.

[5]  S. Tonegawa,et al.  Tγ protein is expressed on murine fetal thymocytes as a disulphide-linked heterodimer , 1987, Nature.

[6]  P. Marrack,et al.  Expression and role of the T cell receptor in early thymocyte differentiation in vitro. , 1987, Journal of immunology.

[7]  J. Coligan,et al.  Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes. , 1986, Science.

[8]  F. Alt,et al.  A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes , 1986, Nature.

[9]  A. Weiss,et al.  Expression of T3 in association with a molecule distinct from the T-cell antigen receptor heterodimer. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[10]  M. Cooper,et al.  Identification of a T3/T cell receptor complex in chickens , 1986, The Journal of experimental medicine.

[11]  L. Hood,et al.  Rearrangement and expression of T cell antigen receptor and gamma genes during thymic development , 1986, The Journal of experimental medicine.

[12]  W. Maloy,et al.  A T3-like protein complex associated with the antigen receptor on murine T cells , 1986, Nature.

[13]  F. Hentges.  [Hybridomas and monoclonal antibodies]. , 1986, Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg.

[14]  A. Tarentino,et al.  Deglycosylation of asparagine-linked glycans by peptide:N-glycosidase F. , 1985, Biochemistry.

[15]  H. Snodgrass,et al.  Expression of T-cell antigen receptor genes during fetal development in the thymus , 1985, Nature.

[16]  S. Tonegawa,et al.  Developmental regulation of T-cell receptor gene expression , 1985, Nature.

[17]  H. Oettgen,et al.  Characterization of the two heavy chains of the T3 complex on the surface of human T lymphocytes. , 1984, The Journal of biological chemistry.

[18]  M. Cooper,et al.  Chicken thymocyte‐specific antigen identified by monoclonal antibodies: ontogeny, tissue distribution and biochemical characterization , 1984, European journal of immunology.

[19]  P. Marrack,et al.  The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody , 1983, The Journal of experimental medicine.

[20]  E. Reinherz,et al.  Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex , 1983, The Journal of experimental medicine.

[21]  F. Jotereau,et al.  Demonstration of a cyclic renewal of the lymphocyte precursor cells in the quail thymus during embryonic and perinatal life. , 1982, Journal of immunology.

[22]  J. Allison,et al.  Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody. , 1982, Journal of immunology.

[23]  C. Jenkin,et al.  Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose. , 1978, Immunochemistry.

[24]  M. Cooper,et al.  Development and distribution of immunoglobulin-containing cells in the chicken. An immunofluorescent analysis using purified antibodies to mu, gamma and light chains. , 1971, Journal of immunology.

[25]  M. Cooper,et al.  THE FUNCTIONS OF THE THYMUS SYSTEM AND THE BURSA SYSTEM IN THE CHICKEN , 1966, The Journal of experimental medicine.