Sex difference in the bed nucleus of the stria terminalis of the human brain

A quantitative analysis of the volume of the darkly staining region of the posteromedial bed nucleus of the stria terminalis was performed on the brains of 26 age‐matched male and female human subjects. We suggest the term “darkly staining posteromedial” component of the bed nucleus of the stria terminalis (BNST‐dspm) to describe this sexually dimorphic region of the human brain. The volume of the BNST‐dspm was 2.47 times greater in males than in females. This region in humans appears to correspond to an area of the bed nucleus of the stria terminalis in laboratory animals that exhibits volumetric and neurochemical sexual dimorphisms, concentrates gonadal steroids, and is anatomically connected to several other sexually dimorphic nuclei. Furthermore, the bed nucleus of the stria terminalis is involved in sexually dimorphic functions, including aggressive behavior, sexual behavior, and gonadotropin secretion, which are also influenced by gonadal steroids. Therefore, it is possible that in human beings as well, gonadal hormones influence the sexual dimorphism in the BNST‐dspm and that this morphological difference, in part, underlies sexually dimorphic function.

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