Centella Asiatica: A Pharmaceutically Important Medicinal Plant

Medicinal plants are the traditional source of pharmaceutically important compounds which are utilized by the pharmaceutical companies for the preparation of several formulations. In the present time, there has been an increase in the use of herbal products around the world. World Health Organisation (WHO) also stated that more that 80% of the world’s population relies on the herbal medicines [1]. The importance of medicinal plants is due to the presence of specific chemical compounds that produce a physiological effect on the human body. These bioactive chemical constituents of plants include saponin, flavanoids, alkaloids, sterols, tannins, phenols [2]. Medicinal plant-based drugs have an advantage over the other drugs because they are simple and offer a broad spectrum of activity. Furthermore, they have very less adverse side effects as compare to the chemotherapeutic drugs. India is rich in medicinal plant diversity and since the ancient times use of drugs of herbal origin is prevalent in the traditional system of medicines such as Ayurveda and Unani. There are about 426 biomes which comprise of different habitat diversity that gives rise to the richest centers for plant genetic resources in the world [3]. Out of 18,665 flowering species, only about 3000 plants has been used for the various formulations in classic system of medicines such as Ayurveda, Siddha and Unani [4].

[1]  Santosh Kumar,et al.  Centella asiatica leaf mediated synthesis of silver nanocolloid and its application as filler in gelatin based antimicrobial nanocomposite film , 2017 .

[2]  Shakeel Ahmed,et al.  A review on plants extract mediated synthesis of silver nanoparticles for antimicrobial applications: A green expertise , 2015, Journal of advanced research.

[3]  A. Roy,et al.  Effect of Different Media and Growth Hormones on Shoot Multiplication of In Vitro Grown Centella asiatica Accessions , 2015 .

[4]  Farjana Akhter,et al.  Anti-hyperglycemic activity of Centella asiatica is partly mediated by carbohydrase inhibition and glucose-fiber binding , 2014, BMC Complementary and Alternative Medicine.

[5]  M. Ekor,et al.  The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety , 2014, Front. Pharmacol..

[6]  J. Abraham,et al.  Ecofriendly synthesis of silver nanoparticles from commercially available plant powders and their antibacterial properties , 2013 .

[7]  U. Parida,et al.  GREEN SYNTHESIS OF SILVER NANOPARTICLES USING LEAVES EXTRACT OF CENTELLA ASIATICA L. FOR STUDIES AGAINST HUMAN PATHOGENS , 2013 .

[8]  Ashish Ranjan Sharma,et al.  Biosynthesis of silver nanoparticles using Ocimum sanctum (Tulsi) leaf extract and screening its antimicrobial activity , 2011 .

[9]  K. Gohil,et al.  Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all , 2010, Indian journal of pharmaceutical sciences.

[10]  Muralidhara,et al.  Prophylaxis with Centella asiatica confers protection to prepubertal mice against 3‐nitropropionic‐acid‐induced oxidative stress in brain , 2010, Phytotherapy research : PTR.

[11]  K. Sakkaravarthi,et al.  Antibacterial activity of herbal extract on pathogens isolated from the swollen hind gut of P. Monodon (fabricus) , 2010 .

[12]  T. Woyengo,et al.  Anticancer effects of phytosterols , 2009, European Journal of Clinical Nutrition.

[13]  Muralidhara,et al.  Prophylactic neuroprotective property of Centella asiatica against 3-nitropropionic acid induced oxidative stress and mitochondrial dysfunctions in brain regions of prepubertal mice. , 2008, Neurotoxicology.

[14]  R. Ferré,et al.  Plant sterol-enriched fermented milk enhances the attainment of LDL-cholesterol goal in hypercholesterolemic subjects , 2008, European journal of nutrition.

[15]  N. Shazili,et al.  Antimicrobial properties of tropical plants against 12 pathogenic bacteria isolated from aquatic organisms , 2008 .

[16]  B. Ravishankar,et al.  Indian systems of medicine: a brief profile. , 2008, African journal of traditional, complementary, and alternative medicines : AJTCAM.

[17]  M. Ramanathan,et al.  Neuroprotective evaluation of standardized extract of Centella asciatica in monosodium glutamate treated rats. , 2007, Indian journal of experimental biology.

[18]  Qudsia Nizami,et al.  Centella asiatica (Linn.) Urban — A Review , 2007 .

[19]  A. Cunningham,et al.  A comparison of cultivation and wild collection of medicinal and aromatic plants under sustainability aspects , 2006 .

[20]  K. Rao,et al.  Centella asiatica (linn) induced behavioural changes during growth spurt period in neonatal rats , 2005 .

[21]  X. Bao,et al.  Ag/SiO2: a novel catalyst with high activity and selectivity for hydrogenation of chloronitrobenzenes. , 2005, Chemical communications.

[22]  R. Pragada,et al.  Cardioprotective activity of Hydrocotyle asiatica L. in ischemia-reperfusion induced myocardial infarction in rats. , 2004, Journal of ethnopharmacology.

[23]  V. Tiwari,et al.  Micropropagation of Centella asiatica (L.), a valuable medicinal herb , 2000, Plant Cell, Tissue and Organ Culture.

[24]  P. Das,et al.  Successful plant regeneration from callus cultures of Centella asiatica (Linn.) Urban , 2004, Plant Growth Regulation.

[25]  S. Sudarslal,et al.  Anti-oxidant activity of Centella asiatica on lymphoma-bearing mice. , 2003, Fitoterapia.

[26]  M. Griffin,et al.  Flight Microangiopathy in Medium-to Long-Distance Flights: Prevention of Edema and Microcirculation Alterations with Total Triterpenic Fraction of Centella asiatica , 2001, Angiology.

[27]  M. Malloy,et al.  A risk factor for atherosclerosis: triglyceride-rich lipoproteins. , 2001, Advances in internal medicine.

[28]  D. Schuppan,et al.  Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica. , 2000, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[29]  I. Mook‐Jung,et al.  Protective effects of asiaticoside derivatives against beta‐amyloid neurotoxicity , 1999, Journal of neuroscience research.

[30]  P. Birembaut,et al.  Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. , 1999, European journal of dermatology : EJD.

[31]  B. Dhawan,et al.  In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. , 1999, Journal of ethnopharmacology.

[32]  Vaidya The status and scope of Indian medicinal plants acting on central nervous system , 1997 .

[33]  P. K. Inamdar,et al.  Determination of biologically active constituents in Centella asiatica , 1996 .

[34]  T. Chakraborty,et al.  Preliminary evidence of antifilarial effect of Centella asiatica on canine dirofilariasis , 1996 .

[35]  F Bonte,et al.  Influence of Asiatic Acid, Madecassic Acid, and Asiaticoside on Human Collagen I Synthesis , 1994, Planta medica.

[36]  T. Chatterjee,et al.  Effects of plant extract Centella asiatica (Linn.) on cold restraint stress ulcer in rats. , 1992, Indian journal of experimental biology.

[37]  G. Belcaro,et al.  [Activity of Centella asiatica in venous insufficiency]. , 1992, Minerva cardioangiologica.

[38]  J. Glasby Dictionary of plants containing secondary metabolites , 1991 .

[39]  R. Tilvis,et al.  Serum plant sterols and their relation to cholesterol absorption. , 1986, The American journal of clinical nutrition.

[40]  New Delhi.,et al.  The wealth of India. A dictionary of Indian raw materials and industrial products. Vol. 7; N-Pe. , 1966 .