Observations on the action of type A botulinum toxin on frog neuromuscular junctions

1. Progressive block of neuromuscular transmission in frog sartorius and gastrocnemius preparations by haemagglutinin‐free crystalline Type A botulinum toxin (BTX) was investigated by in vitro application and by injection of the toxin into living animals.

[1]  L. Simpson.  The interaction between divalent cations and botulinum toxin type A in the paralysis of the rat phrenic nerve-hemidiaphragm preparation. , 1973, Neuropharmacology.

[2]  N. Spitzer.  Miniature end-plate potentials at mammalian neuromuscular junctions poisoned by botulinum toxin. , 1972, Nature: New biology.

[3]  A. J. Harris,et al.  The effect of type D botulinum toxin on frog neuromuscular junctions , 1971, The Journal of physiology.

[4]  B. Dasgupta,et al.  Homogeneity and Molecular Weight of Toxin of Clostridium botulinum Type B , 1968, Journal of bacteriology.

[5]  J. Tapp,et al.  Actions of calcium and magnesium on the rate of onset of botulinum toxin paralysis of the rat diaphragm. , 1967, International journal of neuropharmacology.

[6]  D. A. Boroff,et al.  Chromatographic fractionation of the crystalline toxin of Clostridium botulinum type A. , 1966, Biochemical and biophysical research communications.

[7]  B. Whaler,et al.  Influence of nerve‐ending activity and of drugs on the rate of paralysis of rat diaphragm preparation by Cl. botulinum type A toxin , 1962, The Journal of physiology.

[8]  J. D. Del Castillo,et al.  The electrical activity of the amphibian lymph heart. , 1961, Journal of cellular and comparative physiology.

[9]  S. Thesleff.  Supersensitivity of skeletal muscle produced by botulinum toxin , 1960, The Journal of physiology.

[10]  C. Kupfer.  Selective Block of Synaptic Transmission in Ciliary Ganglion by Type A Botulinus Toxin in Rabbits , 1958, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[11]  J. T. Duff,et al.  STUDIES ON IMMUNITY TO TOXINS OF CLOSTRIDIUM BOTULINUM I. A , 1957, Journal of bacteriology.

[12]  V. Brooks.  An intracellular study of the action of repetitive nerve volleys and of botulinum toxin on miniature end‐plate potentials , 1956, The Journal of physiology.

[13]  B. Katz,et al.  Statistical factors involved in neuromuscular facilitation and depression , 1954, The Journal of physiology.

[14]  B. Katz,et al.  Quantal components of the end‐plate potential , 1954, The Journal of physiology.

[15]  B. Katz,et al.  Changes in end‐plate activity produced by pre‐synaptic polarization , 1954, The Journal of physiology.

[16]  V. Brooks.  The action of botulinum toxin on motor‐nerve filaments , 1954, The Journal of physiology.

[17]  A. Burgen,et al.  The action of botulinum toxin on the neuro‐muscular junction , 1949, The Journal of physiology.

[18]  N. Ambache,et al.  The peripheral action of Cl. botulinum toxin , 1949, The Journal of physiology.

[19]  C. Lamanna,et al.  The Purification and Crystallization of Clostridium botulinum Type A Toxin. , 1946, Science.

[20]  S. W. Kuffler,et al.  NATURE OF THE "ENDPLATE POTENTIAL" IN CURARIZED MUSCLE , 1941 .

[21]  L. Duchen,et al.  The effects of tetanus toxin on neuromuscular transmission and on the morphology of motor end‐plates in slow and fast skeletal muscle of the mouse , 1973, The Journal of physiology.

[22]  C. Lamanna.  The most poisonous poison. , 1959, Science.