GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function

[1]  G. Bonvento,et al.  Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour , 2019, Nature Metabolism.

[2]  K. Timper,et al.  CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance. , 2019, Cell reports.

[3]  K. Kuter,et al.  Astrocyte support is important for the compensatory potential of the nigrostriatal system neurons during early neurodegeneration , 2018, Journal of neurochemistry.

[4]  N. Dencher,et al.  Increased energetic demand supported by mitochondrial electron transfer chain and astrocyte assistance is essential to maintain the compensatory ability of the dopaminergic neurons in an animal model of early Parkinson's disease. , 2019, Mitochondrion.

[5]  Robert W. Taylor,et al.  A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways , 2018, Cell reports.

[6]  K. Pietiläinen,et al.  Metabolomes of mitochondrial diseases and inclusion body myositis patients: treatment targets and biomarkers , 2018, EMBO molecular medicine.

[7]  T. Horvath,et al.  Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. , 2018, Cell reports.

[8]  C. Paladini,et al.  Ventral tegmental area astrocytes orchestrate avoidance and approach behavior , 2018, Nature Communications.

[9]  L. Scorrano,et al.  Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21 , 2018, Cell reports.

[10]  Z. Mari,et al.  Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease , 2018, Nature Medicine.

[11]  D. Drucker.  Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. , 2018, Cell metabolism.

[12]  H. Prokisch,et al.  NDUFB8 Mutations Cause Mitochondrial Complex I Deficiency in Individuals with Leigh-like Encephalomyopathy. , 2018, American journal of human genetics.

[13]  Cole M. Haynes,et al.  UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication , 2018, Cell Research.

[14]  W. Jia,et al.  Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation , 2017, Journal of cellular and molecular medicine.

[15]  M. R. Hayes,et al.  Lateral hypothalamic GLP-1 receptors are critical for the control of food reinforcement, ingestive behavior and body weight , 2017, Molecular Psychiatry.

[16]  N. Chattipakorn,et al.  FGF21 and DPP-4 inhibitor equally prevents cognitive decline in obese rats. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[17]  E. Lo,et al.  FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice , 2018, Molecular Neurobiology.

[18]  J. Zhu,et al.  Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus , 2017, Neuron.

[19]  N. Greig,et al.  Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial , 2017, The Lancet.

[20]  V. Velagapudi,et al.  mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression. , 2017, Cell metabolism.

[21]  J. Poulton,et al.  Use of FGF-21 as a Biomarker of Mitochondrial Disease in Clinical Practice , 2017, Journal of clinical medicine.

[22]  R. Eckel,et al.  Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity , 2017, Diabetes.

[23]  Robert W. Williams,et al.  Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals , 2017, The Journal of cell biology.

[24]  Evelyn Rampler,et al.  Anion-Exchange Chromatography Coupled to High-Resolution Mass Spectrometry: A Powerful Tool for Merging Targeted and Non-targeted Metabolomics. , 2017, Analytical chemistry.

[25]  Matthew J. Potthoff,et al.  OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance , 2017, The EMBO journal.

[26]  K. Timper,et al.  Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity , 2017, Disease Models & Mechanisms.

[27]  D. Cai,et al.  Astrocytic Process Plasticity and IKKβ/NF-κB in Central Control of Blood Glucose, Blood Pressure, and Body Weight. , 2017, Cell metabolism.

[28]  M. Götz,et al.  Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo , 2017, The Journal of Neuroscience.

[29]  S. Rose-John,et al.  IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling. , 2017, Cell reports.

[30]  Laura Petrosini,et al.  Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease , 2017, Nature Communications.

[31]  F. Gómez-Pérez,et al.  Fibroblast growth factor 21 and its novel association with oxidative stress , 2016, Redox biology.

[32]  R. Seeley,et al.  The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice , 2016, Diabetes.

[33]  J. Smeitink,et al.  Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR–RAPTOR , 2016, Journal of Cell Science.

[34]  M. Zeviani,et al.  FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders , 2016, Neurology.

[35]  N. Chattipakorn,et al.  FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats , 2016, Hormones and Behavior.

[36]  C. Kahn,et al.  Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability , 2016, Cell.

[37]  Sujoy Ghosh,et al.  Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle. , 2016, Cell reports.

[38]  A. Gjedde,et al.  In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial , 2016, Front. Aging Neurosci..

[39]  J. Mauer,et al.  Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity , 2016, Cell.

[40]  D. Reiner,et al.  Astrocytes Regulate GLP-1 Receptor-Mediated Effects on Energy Balance , 2016, The Journal of Neuroscience.

[41]  T. Wai,et al.  Mitochondrial Dynamics and Metabolic Regulation , 2016, Trends in Endocrinology & Metabolism.

[42]  R. Rafikov,et al.  Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells , 2015, Redox biology.

[43]  Xianlin Han,et al.  Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism , 2015, Proceedings of the National Academy of Sciences.

[44]  Jing Ma,et al.  A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome. , 2015, Molecular cell.

[45]  Yunlei Yang,et al.  Astrocytes control food intake by inhibiting AGRP neuron activity via adenosine A1 receptors. , 2015, Cell reports.

[46]  J. Flier,et al.  Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice. , 2015, Endocrinology.

[47]  Jesse D. Sengillo,et al.  GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration , 2015, Nature Neuroscience.

[48]  M. Brand,et al.  The contributions of respiration and glycolysis to extracellular acid production. , 2015, Biochimica et biophysica acta.

[49]  J. Gehl,et al.  Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice. , 2015, Metabolism: clinical and experimental.

[50]  E. H. Howlett,et al.  PCR based determination of mitochondrial DNA copy number in multiple species. , 2015, Methods in molecular biology.

[51]  L. Birnbaumer,et al.  Metabolism Regulates the Spontaneous Firing of Substantia Nigra Pars Reticulata Neurons via KATP and Nonselective Cation Channels , 2014, The Journal of Neuroscience.

[52]  T. Horvath,et al.  Mitochondrial dynamics in the central regulation of metabolism , 2014, Nature Reviews Endocrinology.

[53]  S. Kliewer,et al.  FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. , 2014, Cell metabolism.

[54]  J. Hecksher-Sørensen,et al.  The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. , 2014, The Journal of clinical investigation.

[55]  S. Bornstein,et al.  FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting , 2014, Diabetes.

[56]  Jin Kwon Jeong,et al.  Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding , 2014, Nature Neuroscience.

[57]  F. Dai,et al.  A Novel Humanized GLP-1 Receptor Model Enables Both Affinity Purification and Cre-LoxP Deletion of the Receptor , 2014, PloS one.

[58]  L. Partridge,et al.  Interleukin-6 signaling promotes alternative macrophage activation to limit obesity-associated insulin resistance and endotoxemia , 2016 .

[59]  N. Belluardo,et al.  Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1 , 2014, SpringerPlus.

[60]  Simon Hess,et al.  The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry , 2013, Nature Neuroscience.

[61]  T. Foltynie,et al.  Exenatide and the treatment of patients with Parkinson's disease. , 2013, The Journal of clinical investigation.

[62]  S. Schildge,et al.  Isolation and culture of mouse cortical astrocytes. , 2013, Journal of visualized experiments : JoVE.

[63]  Nobuyuki Itoh,et al.  Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine , 2012, Nature Medicine.

[64]  G. Paxinos,et al.  Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates , 2012 .

[65]  K. Zaghloul,et al.  K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration , 2012, Nature Neuroscience.

[66]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[67]  D. Haro,et al.  Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation. , 2012, The Biochemical journal.

[68]  Paul E. Gold,et al.  Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing , 2011, PloS one.

[69]  A. Paetau,et al.  FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study , 2011, The Lancet Neurology.

[70]  G. Mies,et al.  Whiskers Area as Extracerebral Reference Tissue for Quantification of Rat Brain Metabolism Using 18F-FDG PET: Application to Focal Cerebral Ischemia , 2011, The Journal of Nuclear Medicine.

[71]  Sarah A. Stern,et al.  Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation , 2011, Cell.

[72]  A. Dillin,et al.  The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity , 2011, Cell.

[73]  M. Freeman,et al.  Specification and Morphogenesis of Astrocytes , 2010, Science.

[74]  S. Kliewer,et al.  Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. , 2010, Molecular endocrinology.

[75]  J. Calbó,et al.  Hepatic Overexpression of a Constitutively Active Form of Liver Glycogen Synthase Improves Glucose Homeostasis* , 2010, The Journal of Biological Chemistry.

[76]  M. Schwartz,et al.  Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats , 2010, Diabetes.

[77]  K. Kaluarachchi,et al.  Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. , 2010, The Journal of clinical investigation.

[78]  S. Kliewer,et al.  FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response , 2009, Proceedings of the National Academy of Sciences.

[79]  C. Kahn,et al.  Central insulin action regulates peripheral glucose and fat metabolism in mice. , 2008, The Journal of clinical investigation.

[80]  Donghui Zhou,et al.  Phosphorylation of eIF2 Directs ATF5 Translational Control in Response to Diverse Stress Conditions* , 2008, Journal of Biological Chemistry.

[81]  J. Holst,et al.  Glucagon-Like Peptide-1 Inhibits Blood-Brain Glucose Transfer in Humans , 2008, Diabetes.

[82]  F. Ashcroft,et al.  Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. , 2007, Cell metabolism.

[83]  J. Flier,et al.  Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. , 2007, Cell metabolism.

[84]  S. Kliewer,et al.  Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. , 2007, Cell metabolism.

[85]  Jeppe Sturis,et al.  Small-molecule agonists for the glucagon-like peptide 1 receptor , 2007, Proceedings of the National Academy of Sciences.

[86]  L. Ment,et al.  Early Postnatal Astroglial Cells Produce Multilineage Precursors and Neural Stem Cells In Vivo , 2006, The Journal of Neuroscience.

[87]  I. Grundke‐Iqbal,et al.  Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation. , 2006, Journal of Alzheimer's disease : JAD.

[88]  Z. Shen,et al.  2-NBDG as a fluorescent indicator for direct glucose uptake measurement. , 2005, Journal of biochemical and biophysical methods.

[89]  P. E. Gold,et al.  Glucose injections into the dorsal hippocampus or dorsolateral striatum of rats prior to T-maze training: modulation of learning rates and strategy selection. , 2005, Learning & memory.

[90]  Manuel Desco,et al.  The expression of GLP‐1 receptor mRNA and protein allows the effect of GLP‐1 on glucose metabolism in the human hypothalamus and brainstem , 2005, Journal of neurochemistry.

[91]  Rainer Schrader,et al.  Fast and robust registration of PET and MR images of human brain , 2004, NeuroImage.

[92]  N. Canteras,et al.  The Lesion of the Rat Substantia Nigra pars compacta Dopaminergic Neurons as a Model for Parkinson's Disease Memory Disabilities , 2002, Cellular and Molecular Neurobiology.

[93]  Samantha Wietzikoski,et al.  Evidence for the substantia nigra pars compacta as an essential component of a memory system independent of the hippocampal memory system , 2003, Neurobiology of Learning and Memory.

[94]  L. García-Segura,et al.  Increased glucagon-like peptide-1 receptor expression in glia after mechanical lesion of the rat brain , 1999, Neuropeptides.

[95]  S. Vannucci,et al.  Blood—Brain Barrier Glucose Transporter , 1999, Journal of neurochemistry.

[96]  P K Banerjee,et al.  Noninvasive methods for quantitating blood time-activity curves from mouse PET images obtained with fluorine-18-fluorodeoxyglucose. , 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[97]  A. Joyner,et al.  Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene , 1996, Nature Medicine.

[98]  P. E. Gold,et al.  Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[99]  B. Thorens,et al.  Expression of the Glucagon‐Like Peptide‐1 Receptor Gene in Rat Brain , 1996, Journal of neurochemistry.

[100]  C. Montoliu,et al.  Developmental pattern of GFAP and vimentin gene expression in rat brain and in radial glial cultures , 1995, Glia.

[101]  D. Reichling,et al.  Perforated-patch recording with gramicidin avoids artifactual changes in intracellular chloride concentration , 1995, Journal of Neuroscience Methods.

[102]  J. Holst,et al.  Subcutaneous Injection of the Incretin Hormone Glucagon-Like Peptide 1 Abolishes Postprandial Glycemia in NIDDM , 1994, Diabetes Care.

[103]  N. Akaike,et al.  Nystatin perforated patch recording and its applications to analyses of intracellular mechanisms. , 1994, The Japanese journal of physiology.

[104]  R. Horn,et al.  Muscarinic activation of ionic currents measured by a new whole-cell recording method , 1988, The Journal of general physiology.

[105]  J. M. Fernández,et al.  A patch-clamp study of histamine-secreting cells , 1986, The Journal of general physiology.

[106]  P. Ferré,et al.  A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat. , 1985, The Biochemical journal.

[107]  A. Routtenberg,et al.  Memory Disruption by Electrical Stimulation of Substantia Nigra, Pars Compacta , 1973, Science.

[108]  O. H. Lowry,et al.  An enzymic method for measurement of glycogen. , 1967, Analytical biochemistry.