International AIDS Society global scientific strategy: towards an HIV cure 2016
暂无分享,去创建一个
Richard Jefferys | David Margolis | Jintanat Ananworanich | Monique Nijhuis | Brigitte Autran | Galit Alter | Sarah Palmer | Douglas Richman | Hans-Peter Kiem | Nir Eyal | Joseph D Tucker | Guido Silvestri | Ying-Ru Lo | Daniel Kuritzkes | Sarah Fidler | D. Richman | R. Walensky | Zhiwei Chen | G. Henderson | D. Kuritzkes | I. Wilson | J. van Lunzen | B. Autran | S. Lewin | J. Lifson | D. Douek | J. Ananworanich | J. Siliciano | J. Mellors | N. Eyal | J. McCune | G. Alter | T. Henrich | M. Ott | G. Silvestri | B. Spire | S. Deeks | J. Zack | H. Kiem | P. Cannon | É. Cohen | M. Benkirane | D. Persaud | M. Tolstrup | J. Singh | D. Barouch | J. Tucker | S. Eholie | R. Jefferys | N. Chomont | K. Moodley | M. Nijhuis | A. Sáez-Cirión | F. Barré-Sinoussi | S. Palmer | Y. Lo | Nicolas Chomont | Martin Tolstrup | Steven G Deeks | Ira Wilson | J. Auerbach | Cynthia I. Grossman | S. Fidler | Bruno Spire | Deborah Persaud | Jerome Singh | Asier Saez-Cirion | Melanie Ott | Sharon R Lewin | Paula Cannon | Joseph McCune | S. Valente | G. Behrens | Dan H Barouch | Zhiwei Chen | P. Newman | Marina Cavazzana | Giulio Maria Corbelli | Jan van Lunzen | Monsef Benkirane | Anna Laura Ross | Daniel Douek | Jeffrey D Lifson | John Mellors | Françoise Barre-Sinoussi | Judith Auerbach | Georg Behrens | Éric A Cohen | Serge Eholié | Laurindo Garcia | Cynthia Grossman | Gail Henderson | Timothy J Henrich | Keymanthri Moodley | Peter A Newman | Moses Supercharger Nsubuga | Matthew Sharp | Janet Siliciano | Jeffrey Taylor | Susana Valente | Rochelle Walensky | Jerome Zack | G. Corbelli | A. Ross | M. Cavazzana | D. Margolis | M. Nsubuga | L. Garcia | M. Sharp | Jeffrey Taylor | J. Singh | J. Singh
[1] M. Lederman,et al. Interleukin-7 promotes HIV persistence during antiretroviral therapy. , 2013, Blood.
[2] J. Church. Depletion of Latent HIV-1 Infection in Vivo: A Proof-of-Concept Study , 2006, Pediatrics.
[3] P. Lemey,et al. The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time , 2013, Proceedings of the National Academy of Sciences.
[4] Sarah Palmer,et al. Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial. , 2014, The lancet. HIV.
[5] B. Korber,et al. Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E , 2016, Science.
[6] Brigitte Autran,et al. Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study , 2013, PLoS pathogens.
[7] J. Mellors,et al. HIV-1 Virion Production from Single Inducible Proviruses following T-Cell Activation Ex Vivo , 2015, Journal of Virology.
[8] J. Ananworanich,et al. Stakeholder Engagement in HIV Cure Research: Lessons Learned from Other HIV Interventions and the Way Forward. , 2015, AIDS patient care and STDs.
[9] D. Havlir,et al. The distribution of HIV DNA and RNA in cell subsets differs in gut and blood of HIV-positive patients on ART: implications for viral persistence. , 2013, The Journal of infectious diseases.
[10] R. Gottardo,et al. Therapeutic vaccination expands and improves the function of the HIV-specific memory T-cell repertoire. , 2013, The Journal of infectious diseases.
[11] C. Rouzioux,et al. HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report. , 2016, The lancet. HIV.
[12] H. Hatano,et al. Reduction of HIV Persistence Following Transplantation in HIV‐Infected Kidney Transplant Recipients , 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
[13] Anitha Rao,et al. RNA-Based Gene Therapy for HIV with Lentiviral Vector–Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma , 2010, Science Translational Medicine.
[14] M. McCarter,et al. CTL Fail to Accumulate at Sites of HIV-1 Replication in Lymphoid Tissue12 , 2007, The Journal of Immunology.
[15] M. Cotton,et al. HIV cure research in South Africa: a preliminary exploration of stakeholder perspectives , 2016, AIDS care.
[16] Rebecca Hoh,et al. Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study. , 2015, The lancet. HIV.
[17] D. Richman,et al. Influence of age at virologic control on peripheral blood human immunodeficiency virus reservoir size and serostatus in perinatally infected adolescents. , 2014, JAMA pediatrics.
[18] Jeffrey N. Martin,et al. HIV antibody characterization as a method to quantify reservoir size during curative interventions. , 2014, The Journal of infectious diseases.
[19] A. Tanuri,et al. Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase C&dgr;–NF-&kgr;B signaling , 2014, AIDS.
[20] A. Fauci,et al. An HIV cure: feasibility, discovery, and implementation. , 2014, JAMA.
[21] M. Churchill,et al. HIV-1 transcriptional regulation in the central nervous system and implications for HIV cure research , 2014, Journal of NeuroVirology.
[22] B. Berkhout,et al. Dendritic cell type-specific HIV-1 activation in effector T cells: implications for latent HIV-1 reservoir establishment , 2015, AIDS.
[23] S. Lewin,et al. Effect of ipilimumab on the HIV reservoir in an HIV-infected individual with metastatic melanoma. , 2015, AIDS.
[24] M. Weinstein,et al. HIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy? , 2014, PloS one.
[25] Daniel I. S. Rosenbloom,et al. Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations. , 2015, The Journal of clinical investigation.
[26] P. Volberding,et al. Words matter: Discussing research towards an HIV cure in research and clinical contexts. , 2014, Journal of acquired immune deficiency syndromes.
[27] J. Hoxie,et al. Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy–treated macaques , 2015, Nature Methods.
[28] G. Pantaleo,et al. PD-1+ and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals , 2016, Nature Medicine.
[29] R. Siliciano,et al. Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient , 2013, PLoS pathogens.
[30] J. Mascola,et al. Activation and lysis of human CD4 cells latently infected with HIV-1 , 2015, Nature Communications.
[31] D. Richman,et al. Absence of detectable HIV-1 viremia after treatment cessation in an infant. , 2013, The New England journal of medicine.
[32] Pamela A Shaw,et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. , 2014, The New England journal of medicine.
[33] S. Deeks,et al. Immunologic strategies for HIV-1 remission and eradication , 2014, Science.
[34] Matthew S. Lewis,et al. Profound early control of highly pathogenic SIV by an effector-memory T cell vaccine , 2011, Nature.
[35] E. Thiel,et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. , 2009, The New England journal of medicine.
[36] Eric Verdin,et al. An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients , 2013, PLoS pathogens.
[37] Carl June,et al. Chemokine receptor 5 knockout strategies , 2011, Current opinion in HIV and AIDS.
[38] M. Nussenzweig,et al. Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice , 2014, Cell.
[39] C. Rouzioux,et al. A low HIV-DNA level in peripheral blood mononuclear cells at antiretroviral treatment interruption predicts a higher probability of maintaining viral control , 2015, AIDS.
[40] M. Lederman,et al. The size of the expressed HIV reservoir predicts timing of viral rebound after treatment interruption , 2015, AIDS.
[41] R. Siliciano,et al. Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies , 2013, PLoS pathogens.
[42] D. Hazuda,et al. Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy , 2014, PLoS pathogens.
[43] M. Swanson,et al. Generation of HIV Latency in Humanized BLT Mice , 2011, Journal of Virology.
[44] S. Hughes,et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells , 2014, Science.
[45] J. Mellors,et al. Lack of Detectable HIV-1 Molecular Evolution during Suppressive Antiretroviral Therapy , 2014, PLoS pathogens.
[46] M. Hudgens,et al. Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART , 2014, PLoS pathogens.
[47] Matthew S. Lewis,et al. Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms , 2013, Science.
[48] E. Rosenberg,et al. HIV-1 persistence in CD4+ T cells with stem cell-like properties , 2014, Nature Medicine.
[49] S. Lewin,et al. Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4+ T cells in HIV-infected individuals on antiretroviral therapy , 2016, AIDS.
[50] Brendan B. Larsen,et al. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection , 2014, Science.
[51] J. Eron,et al. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy , 2012, Nature.
[52] J. Tucker,et al. Social and ethical implications of HIV cure research , 2014, AIDS.
[53] R. Siliciano,et al. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations , 2015, Nature.
[54] D. Cooper,et al. HIV DNA Subspecies Persist in both Activated and Resting Memory CD4+ T Cells during Antiretroviral Therapy , 2014, Journal of Virology.
[55] G. Henderson,et al. What motivates participation in HIV cure trials? A call for real-time assessment to improve informed consent , 2015, Journal of virus eradication.
[56] R. Siliciano,et al. Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough. , 2008, Cell host & microbe.
[57] L. Trautmann,et al. The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency , 2015, mBio.
[58] Michael S. Seaman,et al. Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 , 2015, Nature.
[59] A. De Maria,et al. Absence of HIV-1 after treatment cessation in an infant. , 2014, The New England journal of medicine.
[60] Nancie M Archin,et al. Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies. , 2015, The Journal of infectious diseases.
[61] J. Karn,et al. Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction , 2010, Journal of Virology.
[62] Sarah B. Laskey,et al. Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure , 2013, Cell.
[63] Sarah Palmer,et al. HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects , 2010, Nature Medicine.
[64] Baoshan Zhang,et al. AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges , 2015, Nature.
[65] Emily B Hanhauser,et al. Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell Transplantation , 2014, Annals of Internal Medicine.
[66] Jack T Stapleton,et al. The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation , 2010, Science.
[67] Z. Klase,et al. Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells. , 2014, Immunity.
[68] Anthony R Cillo,et al. Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy , 2014, Proceedings of the National Academy of Sciences.
[69] Matthew S. Lewis,et al. Immune clearance of highly pathogenic SIV infection , 2013, Nature.
[70] G. Henderson. The ethics of HIV "cure" research: what can we learn from consent forms? , 2015, AIDS research and human retroviruses.
[71] L. Picker,et al. A B cell follicle sanctuary permits persistent productive SIV infection in elite controllers , 2014, Nature Medicine.
[72] J. Clements,et al. A Murine Viral Outgrowth Assay to Detect Residual HIV Type 1 in Patients With Undetectable Viral Loads. , 2015, The Journal of infectious diseases.
[73] O. Yang,et al. In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem Cells , 2012, PLoS pathogens.
[74] R. Siliciano,et al. Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. , 2012, Immunity.
[75] S. Valente,et al. Targeting HIV transcription: the quest for a functional cure. , 2015, Current topics in microbiology and immunology.
[76] R. Walensky,et al. The HIV cure research agenda: the role of mathematical modelling and cost-effectiveness analysis , 2015, Journal of virus eradication.
[77] A. Haase,et al. Macrophages sustain HIV replication in vivo independently of T cells. , 2016, The Journal of clinical investigation.
[78] Alan S Perelson,et al. Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues , 2014, Proceedings of the National Academy of Sciences.
[79] H. Kiem,et al. Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates. , 2010, The Journal of clinical investigation.
[80] D. Irvine,et al. Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes , 2014, PLoS pathogens.
[81] P. Goulder,et al. Immunity to HIV in Early Life , 2014, Front. Immunol..
[82] J. Lifson,et al. Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy , 2015, Antimicrobial Agents and Chemotherapy.
[83] Michael S. Seaman,et al. Therapeutic Efficacy of Potent Neutralizing HIV-1-Specific Monoclonal Antibodies in SHIV-Infected Rhesus Monkeys , 2013, Nature.
[84] M. Carrington,et al. HIV-1 DNA predicts disease progression and post-treatment virological control , 2014, eLife.
[85] G. Pantaleo,et al. The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo , 2015, PLoS pathogens.
[86] 王涛,et al. 联合国HIV/AIDS综合规划(UNAIDS) , 1996 .
[87] Geneviève Boucher,et al. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation , 2009, Nature Medicine.
[88] T. Chun,et al. Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir , 2014, Proceedings of the National Academy of Sciences.
[89] Peter A. Newman,et al. Advancing community stakeholder engagement in biomedical HIV prevention trials: principles, practices and evidence , 2014, Expert review of vaccines.
[90] C. Van Lint,et al. Transcriptional activation and chromatin remodeling of the HIV‐1 promoter in response to histone acetylation. , 1996, The EMBO journal.
[91] Wei-Ting Hwang,et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. , 2014, The New England journal of medicine.
[92] J. Mascola,et al. Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection , 2015, Science Translational Medicine.
[93] Bernd Hauck,et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. , 2013, The New England journal of medicine.
[94] R. Siliciano,et al. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism , 2013, Cell cycle.
[95] G. Alter,et al. Exploring the potential of monoclonal antibody therapeutics for HIV-1 eradication. , 2015, AIDS research and human retroviruses.
[96] J. Delfraissy,et al. Past, present and future: 30 years of HIV research , 2013, Nature Reviews Microbiology.
[97] M. Lederman,et al. Towards an HIV cure: a global scientific strategy , 2012, Nature Reviews Immunology.
[98] Trevor Bedford,et al. Persistent HIV-1 replication maintains the tissue reservoir during therapy , 2015, Nature.
[99] H. Liao,et al. Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells. , 2015, The Journal of clinical investigation.
[100] P. Volberding,et al. Exploring the social meaning of curing HIV: a qualitative study of people who inject drugs in Guangzhou, China. , 2015, AIDS research and human retroviruses.
[101] R. Lempicki,et al. Lifespan of effector memory CD4+ T cells determined by replication-incompetent integrated HIV-1 provirus , 2014, AIDS.
[102] H. Schuitemaker,et al. OKT3 and IL-2 Treatment for Purging of the Latent HIV-1 Reservoir in Vivo Results in Selective Long-Lasting CD4+ T Cell Depletion , 2001, Journal of Clinical Immunology.
[103] G. Yenokyan,et al. Cell-Associated HIV-1 DNA and RNA Decay Dynamics During Early Combination Antiretroviral Therapy in HIV-1-Infected Infants. , 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[104] Yang Shi,et al. The Human Factors YY1 and LSF Repress the Human Immunodeficiency Virus Type 1 Long Terminal Repeat via Recruitment of Histone Deacetylase 1 , 2000, Journal of Virology.
[105] A. Samri,et al. Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission. , 2015, The Journal of antimicrobial chemotherapy.
[106] Suha M. Saleh,et al. Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells , 2013, AIDS.
[107] S. Hughes,et al. Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo , 2016, Proceedings of the National Academy of Sciences.
[108] O. Witte,et al. Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells , 2015, Proceedings of the National Academy of Sciences.
[109] V. Calvez,et al. Treatment intensification followed by interleukin-7 reactivates HIV without reducing total HIV DNA: a randomized trial , 2016, AIDS.
[110] D. Hazuda,et al. A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals , 2015, EBioMedicine.
[111] J. Ananworanich,et al. Reduced markers of HIV persistence and restricted HIV-specific immune responses after early antiretroviral therapy in children , 2014, AIDS.
[112] Fan Yang,et al. RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection , 2014, Proceedings of the National Academy of Sciences.
[113] Rebecca Hoh,et al. Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial. , 2013, The Journal of infectious diseases.
[114] A. Perelson,et al. Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection , 2012, Proceedings of the National Academy of Sciences.
[115] Jinyan Liu,et al. Rapid Seeding of the Viral Reservoir Prior to SIV Viremia in Rhesus Monkeys , 2014, Nature.
[116] Shiu-Lok Hu,et al. Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model. , 2013, Blood.
[117] R. Siliciano,et al. Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay , 2013, PLoS pathogens.
[118] R. Phillips,et al. Immunological biomarkers predict HIV-1 viral rebound after treatment interruption , 2015, Nature Communications.
[119] J. Lifson,et al. Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques. , 2015, The Journal of clinical investigation.
[120] Jeffrey N. Martin,et al. Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells. , 2013, The Journal of infectious diseases.
[121] J. Church. Vectored Immunoprophylaxis Protects Humanized Mice From Mucosal HIV Transmission , 2014, Pediatrics.
[122] M. Marsden,et al. HIV Latency in the Humanized BLT Mouse , 2011, Journal of Virology.
[123] J. Amon. Dangerous medicines: Unproven AIDS cures and counterfeit antiretroviral drugs , 2008, Globalization and health.