Short and long sleep and sleeping pills. Is increased mortality associated?

Prospective epidemiologic data of the American Cancer Society disclosed that reported usual sleep durations among groups who complained of insomnia and sleeping pill use "often" overlapped with those of groups who had no complaints. Reports of insomnia were not consistently associated with increased mortality when several factors were controlled; however, men who reported usually sleeping less than four hours were 2.80 times as likely to have died within six years as men who reported 7.0 to 7.9 hours of sleep. The ratio for women was 1.48. Men and women who reported sleeping ten hours or more had about 1.8 times the mortality of those who reported 7.0 to 7.9 hours of sleep. Those who reported using sleeping pills "often" had 1.5 times the mortality of those who "never" used sleeping pills. These results do not prove that mortality could be reduced by altering sleep durations or by reducing hypnotic prescribing. Rather, studies are needed to determine the causes of these mortality risk factors.

[1]  O. Miettinen,et al.  Standardization of risk ratios. , 1972, American journal of epidemiology.

[2]  L. Breslow,et al.  Relationship of physical health status and health practices. , 1972, Preventive medicine.

[3]  E. Bixler,et al.  Effectiveness of hypnotic drugs with prolonged use: Flurazepam and pentobarbital , 1975, Clinical pharmacology and therapeutics.

[4]  D. Greenblatt,et al.  Rational use of psychotropic drugs. I. Hypnotics. , 1974, American journal of hospital pharmacy.

[5]  A. Kales,et al.  Are over-the-counter sleep medications effective? All-night EEG studies. , 1971, Current therapeutic research, clinical and experimental.

[6]  E. Bixler,et al.  Sleep Profiles of Insomnia and Hypnotic Drug Effectiveness , 1975 .

[7]  E. C. Hammond,et al.  Smoking in relation to physical complaints. , 1961, Archives of environmental health.

[8]  C. Guilleminault,et al.  Two occult causes of insomnia and their therapeutic problems. , 1976, Archives of general psychiatry.

[9]  P. Hauri,et al.  Effectiveness of intermediate‐term use of secobarbital , 1976, Clinical pharmacology and therapeutics.

[10]  A. Kales,et al.  Personality patterns in insomnia. Theoretical implications. , 1976, Archives of general psychiatry.

[11]  Erwin N. Koranyi Fatalities in 2,070 Psychiatric Outpatients: Preventative Features , 1977 .

[12]  W C Dement,et al.  Self-reports versus sleep laboratory findings in 122 drug-free subjects with complaints of chronic insomnia. , 1976, The American journal of psychiatry.

[13]  Carolyn J. Hursch,et al.  Electroencephalography (EEG) of human sleep : clinical applications , 1974 .

[14]  C. Guilleminault,et al.  Sleep-related periodic myoclonus in patients complaining of insomnia. , 1975, Transactions of the American Neurological Association.

[15]  F. Snyder,et al.  Recorded and reported sleep in chronic primary insomnia. , 1976, Archives of general psychiatry.

[16]  E. Kahn,et al.  THE SLEEP CHARACTERISTICS OF THE NORMAL AGED MALE , 1969, The Journal of nervous and mental disease.

[17]  E. Bixler,et al.  Chronic hypnotic-drug use. Ineffectiveness, drug-withdrawal insomnia, and dependence. , 1974, JAMA.

[18]  W C Dement,et al.  The sleep apnea syndromes. , 1976, Annual review of medicine.

[19]  F. Halberg,et al.  Chronobiology of the life sequence. , 1972 .

[20]  E. C. Hammond,et al.  SOME PRELIMINARY FINDINGS ON PHYSICAL COMPLAINTS FROM A PROSPECTIVE STUDY OF 1,064,004 MEN AND WOMEN. , 1964, American journal of public health and the nation's health.

[21]  Q. Regestein,et al.  Treating insomnia: a practical guide for managing chronic sleeplessness, circa 1975. , 1976, Comprehensive psychiatry.

[22]  N B Belloc,et al.  Relationship of health practices and mortality. , 1973, Preventive medicine.

[23]  A. Kales,et al.  Hypnotic drugs and their effectiveness. All-night EEG studies of insomniac subjects. , 1970, Archives of general psychiatry.

[24]  J. Yager,et al.  Sleep Disorder and Psychobiological Symptomatology in Male Psychiatric Outpatients and Male Nonpatients , 1976, Psychosomatic medicine.

[25]  P. Bickel,et al.  Sex Bias in Graduate Admissions: Data from Berkeley , 1975, Science.

[26]  R. Walter,et al.  MEASUREMENTS OF ALL‐NIGHT SLEEP IN NORMAL ELDERLY PERSONS: EFFECTS OF AGING * , 1967, Journal of the American Geriatrics Society.