SPECT-CT

In view of the commercial success of integrated PET/CT scanners, there is an increasing interest in comparable SPECT/CT systems. SPECT in combination with CT enables a direct correlation of anatomic information and functional information, resulting in better localization and definition of scintigraphic findings. Besides anatomic referencing, the added value of CT coregistration is based on the attenuation correction capabilities of CT. The number of clinical studies is limited, but pilot studies have indicated a higher specificity and a significant reduction in indeterminate findings. The superiority of SPECT/CT over planar imaging or SPECT has been demonstrated in bone scintigraphy, somatostatin receptor scintigraphy, parathyroid scintigraphy, and adrenal gland scintigraphy. Also, rates of detection of sentinel nodes by biopsy can be increased with SPECT/CT. This review highlights recent technical developments in integrated SPECT/CT systems and summarizes the current literature on potential clinical uses and future directions for SPECT/CT in cardiac, neurologic, and oncologic applications.

[1]  M. Petretta,et al.  Assessment of coronary flow reserve by sestamibi imaging in patients with typical chest pain and normal coronary arteries , 2008, European Journal of Nuclear Medicine and Molecular Imaging.

[2]  Kevin Fung,et al.  Accuracy of technetium‐99m SPECT‐CT hybrid images in predicting the precise intraoperative anatomical location of parathyroid adenomas , 2008, Head & neck.

[3]  C. Cousens,et al.  SPECTCT cerebral perfusion scintigraphy; is the low-dose CT component of diagnostic value? , 2008, Clinical radiology.

[4]  J. Mangrum,et al.  The prevalence of extracardiac findings by multidetector computed tomography before atrial fibrillation ablation. , 2008, American heart journal.

[5]  I. Buvat,et al.  Comparison between 2D and 3D dosimetry protocols in 90Y-ibritumomab tiuxetan radioimmunotherapy of patients with non-Hodgkin's lymphoma. , 2008, Cancer biotherapy & radiopharmaceuticals.

[6]  Brian F. Hutton,et al.  Sources of attenuation-correction artefacts in cardiac PET/CT and SPECT/CT , 2008, European Journal of Nuclear Medicine and Molecular Imaging.

[7]  L. Shaw,et al.  Potential impact of noncontrast computed tomography as gatekeeper for myocardial perfusion positron emission tomography in patients admitted to the chest pain unit. , 2008, The American journal of cardiology.

[8]  Jeroen J. Bax,et al.  Comparison of multislice computed tomography to gated single-photon emission computed tomography for imaging of healed myocardial infarcts. , 2008, The American journal of cardiology.

[9]  Guido Germano,et al.  Applications and software techniques for integrated cardiac multimodality imaging , 2008, Expert review of cardiovascular therapy.

[10]  Oliver Lindner,et al.  Optimisation of protocol for low dose CT-derived attenuation correction in myocardial perfusion SPECT imaging , 2008, European Journal of Nuclear Medicine and Molecular Imaging.

[11]  G. Martinelli,et al.  High-Dose Radioimmunotherapy with 90Y-Ibritumomab Tiuxetan: Comparative Dosimetric Study for Tailored Treatment , 2007, Journal of Nuclear Medicine.

[12]  I. V. D. van der Ploeg,et al.  The Additional Value of SPECT/CT in Lymphatic Mapping in Breast Cancer and Melanoma , 2007, Journal of Nuclear Medicine.

[13]  Joachim Hornegger,et al.  Registration of Cardiac SPECT/CT Data Through Weighted Intensity Co-occurrence Priors , 2007, MICCAI.

[14]  C. Love,et al.  Diagnostic imaging tests and microbial infections , 2007, Cellular microbiology.

[15]  S. Nekolla,et al.  Attenuation correction in cardiac PET/CT with three different CT protocols: a comparison with conventional PET , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[16]  Tinsu Pan,et al.  Frequent Diagnostic Errors in Cardiac PET/CT Due to Misregistration of CT Attenuation and Emission PET Images: A Definitive Analysis of Causes, Consequences, and Corrections , 2007, Journal of Nuclear Medicine.

[17]  F. Bengel,et al.  Attenuation Correction in Myocardial Perfusion SPECT/CT: Effects of Misregistration and Value of Reregistration , 2007, Journal of Nuclear Medicine.

[18]  Harvey A. Ziessman,et al.  Comparison of SPECT/CT, SPECT, and Planar Imaging with Single- and Dual-Phase 99mTc-Sestamibi Parathyroid Scintigraphy , 2007, Journal of Nuclear Medicine.

[19]  R. Wahl,et al.  Three-Dimensional Radiobiologic Dosimetry: Application of Radiobiologic Modeling to Patient-Specific 3-Dimensional Imaging–Based Internal Dosimetry , 2007, Journal of Nuclear Medicine.

[20]  Nirav P. Shah,et al.  Infection Scintigraphy: Added Value of Single-photon Emission Computed Tomography/Computed Tomography Fusion Compared With Traditional Analysis , 2007, Journal of computer assisted tomography.

[21]  Hatem Alkadhi,et al.  Cardiac Image Fusion from Stand-Alone SPECT and CT: Clinical Experience , 2007, Journal of Nuclear Medicine.

[22]  Richard L Wahl,et al.  Prevalence of misregistration between SPECT and CT for attenuation-corrected myocardial perfusion SPECT , 2007, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[23]  Martin A Lodge,et al.  Methodology for quantifying absolute myocardial perfusion with PET and SPECT , 2007, Current cardiology reports.

[24]  Haim Azhari,et al.  Correction of Heart Motion Due to Respiration in Clinical Myocardial Perfusion SPECT Scans Using Respiratory Gating , 2007, Journal of Nuclear Medicine.

[25]  Mark T Madsen,et al.  Recent Advances in SPECT Imaging , 2007, Journal of Nuclear Medicine.

[26]  Rafael Beyar,et al.  Integrated single-photon emission computed tomography and computed tomography coronary angiography for the assessment of hemodynamically significant coronary artery lesions. , 2007, Journal of the American College of Cardiology.

[27]  W. Wijns.  Anatomic-functional imaging by single-photon emission computed tomography/computed tomography as the cornerstone of diagnosis and treatment for coronary patients: a glimpse into the (near) future? , 2007, Journal of the American College of Cardiology.

[28]  Ur Metser,et al.  Improved sentinel node identification by SPECT/CT in overweight patients with breast cancer. , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[29]  U. Metser,et al.  SPECT/multislice low-dose CT: a clinically relevant constituent in the imaging algorithm of nononcologic patients referred for bone scintigraphy. , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[30]  Nassir Navab,et al.  Artifacts from misaligned CT in cardiac perfusion PET/CT studies: frequency, effects, and potential solutions. , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[31]  G. Bakale,et al.  Synergistic value of single-photon emission computed tomography/computed tomography fusion to radioimmunoscintigraphic imaging of prostate cancer. , 2007, Seminars in nuclear medicine.

[32]  P. Mikosch,et al.  Sentinel node SPECT-CT in breast cancer , 2007, Nuklearmedizin.

[33]  G. Antoch,et al.  Can PET/CT replace separate diagnostic CT for cancer imaging? Optimizing CT protocols for imaging cancers of the chest and abdomen. , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[34]  H. Steinert,et al.  Single-photon emission computed tomography/computed tomographyfor sentinel node mapping in breast cancer. , 2007, Seminars in nuclear medicine.

[35]  H. Amthauer,et al.  Impact of image fusion and attenuation correction by SPECT-CT on the scintigraphic detection of parathyroid adenomas , 2007, Nuklearmedizin.

[36]  D. Berman,et al.  Comparative use of radionuclide stress testing, coronary artery calcium scanning, and noninvasive coronary angiography for diagnostic and prognostic cardiac assessment. , 2007, Seminars in nuclear medicine.

[37]  Heinrich R Schelbert,et al.  Improvements in cancer staging with PET/CT: literature-based evidence as of September 2006. , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[38]  C. Claussen,et al.  Added value of SPECT/CT in patients suspected of having bone infection: preliminary results , 2007, Archives of Orthopaedic and Trauma Surgery.

[39]  L. Fig,et al.  Contemporary adrenal scintigraphy , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[40]  Hatem Alkadhi,et al.  Validation of a new cardiac image fusion software for three-dimensional integration of myocardial perfusion SPECT and stand-alone 64-slice CT angiography , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[41]  Dale L Bailey,et al.  SPECT/CT imaging using a spiral CT scanner for anatomical localization: Impact on diagnostic accuracy and reporter confidence in clinical practice , 2006, Nuclear medicine communications.

[42]  G. Bakale,et al.  Fused SPECT/CT imaging of Peri-iliopsoas infection using Indium-111-labeled leukocytes. , 2006, Clinical nuclear medicine.

[43]  Orazio Schillaci,et al.  Usefulness of hybrid SPECT/CT in 99mTc-HMPAO-labeled leukocyte scintigraphy for bone and joint infections. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[44]  Nirav P. Shah,et al.  Endocrine Neoplasm Scintigraphy: Added Value of Fusing SPECT/CT Images Compared With Traditional Side-by-Side Analysis , 2006, Clinical nuclear medicine.

[45]  Brad J Kemp,et al.  Single-photon emission computed tomography/computed tomography: basic instrumentation and innovations. , 2006, Seminars in nuclear medicine.

[46]  Z. Gil,et al.  Lymphoscintigraphy for sentinel node mapping using a hybrid single photon emission CT (SPECT)/CT system in oral cavity squamous cell carcinoma , 2006, Head & neck.

[47]  K. Juergens,et al.  Whole-body PET/CT with 11C-meta-hydroxyephedrine in tumors of the sympathetic nervous system: feasibility study and comparison with 123I-MIBG SPECT/CT. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[48]  G. Nakazawa,et al.  Noncardiac findings in cardiac imaging with multidetector computed tomography. , 2006, Journal of the American College of Cardiology.

[49]  T. Kauppinen,et al.  Sentinel lymph node mapping using SPECT–CT fusion imaging in patients with oral cavity squamous cell carcinoma , 2006, European Archives of Oto-Rhino-Laryngology and Head & Neck.

[50]  A. Sherif,et al.  Hybrid SPECT-CT: an additional technique for sentinel node detection of patients with invasive bladder cancer. , 2006, European urology.

[51]  L. Fig,et al.  Adrenal gland scintigraphy. , 2006, Seminars in nuclear medicine.

[52]  Torsten Kuwert,et al.  SPECT-guided CT for evaluating foci of increased bone metabolism classified as indeterminate on SPECT in cancer patients. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[53]  G. Luijckx,et al.  Persistent aseptic meningitis due to post-surgical spinal CSF leakage: value of fused 111mIn-DTPA SPECT-CT cisternography , 2006, European Journal of Nuclear Medicine and Molecular Imaging.

[54]  A. Engel,et al.  SPECT/CT using 67Ga and 111In-labeled leukocyte scintigraphy for diagnosis of infection. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[55]  Joachim Hornegger,et al.  Isotropic reconstruction of SPECT data using OSEM3D: correlation with CT. , 2006, Academic radiology.

[56]  Thomas F Hany,et al.  Integrated PET/CT: current applications and future directions. , 2006, Radiology.

[57]  R. Zheng,et al.  [Clinical application of sentinel lymph node detection to early stage cervical cancer]. , 2006, Ai zheng = Aizheng = Chinese journal of cancer.

[58]  Henry R. Halperin,et al.  Contrast-Enhanced Multidetector Computed Tomography Viability Imaging After Myocardial Infarction: Characterization of Myocyte Death, Microvascular Obstruction, and Chronic Scar , 2006, Circulation.

[59]  J. Marving,et al.  The role of SPECT-CT in the lymphoscintigraphic identification of sentinel nodes in patients with oral cancer , 2006, Acta oto-laryngologica.

[60]  Tracy L Faber,et al.  Automated quality control of emission-transmission misalignment for attenuation correction in myocardial perfusion imaging with SPECT-CT systems. , 2006, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[61]  W. Tindale,et al.  The clinical impact of a combined gamma camera/CT imaging system on somatostatin receptor imaging of neuroendocrine tumours. , 2006, Clinical radiology.

[62]  A. Engel,et al.  Images in cardiovascular medicine. Hybrid cardiac single photon emission computed tomography/computed tomography imaging with myocardial perfusion single photon emission computed tomography and multidetector computed tomography coronary angiography for the assessment of unstable angina pectoris afte , 2006, Circulation.

[63]  Kazuo Awai,et al.  Added value of SPECT/CT fusion in assessing suspected bone metastasis: comparison with scintigraphy alone and nonfused scintigraphy and CT. , 2006, Radiology.

[64]  Michael Lassmann,et al.  The impact of PET and SPECT on dosimetry for targeted radionuclide therapy. , 2006, Zeitschrift fur medizinische Physik.

[65]  R. Ellis,et al.  Fused radioimmunoscintigraphy for treatment planning. , 2006, Reviews in urology.

[66]  2006 Image of the Year: Focus on cardiac SPECT/CT. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[67]  D. Berman,et al.  Roles of nuclear cardiology, cardiac computed tomography, and cardiac magnetic resonance: assessment of patients with suspected coronary artery disease. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[68]  U. Metser,et al.  Lymphoscintigraphic sentinel node identification in patients with breast cancer: the role of SPECT-CT , 2006, European Journal of Nuclear Medicine and Molecular Imaging.

[69]  I. Narabayashi,et al.  Comparison of methods of attenuation and scatter correction in brain perfusion SPECT. , 2005, Journal of nuclear medicine technology.

[70]  Frans J. Th. Wackers,et al.  Clinical validation of SPECT attenuation correction using x-ray computed tomography—derived attenuation maps: Multicenter clinical trial with angiographic correlation , 2005, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[71]  R. Bale,et al.  Image fusion analysis of 99mTc-HYNIC-Tyr3-octreotide SPECT and diagnostic CT using an immobilisation device with external markers in patients with endocrine tumours , 2005, European Journal of Nuclear Medicine and Molecular Imaging.

[72]  E. Even-Sapir.  Imaging of malignant bone involvement by morphologic, scintigraphic, and hybrid modalities. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[73]  Klaus Bacher,et al.  Patient dosimetry in radionuclide therapy: the whys and the wherefores , 2005, Nuclear medicine communications.

[74]  Cyrill Burger,et al.  Integrated PET/CT for the assessment of coronary artery disease: a feasibility study. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[75]  Eugenio Picano,et al.  Economic and biological costs of cardiac imaging , 2005, Cardiovascular ultrasound.

[76]  Mingshan Sun,et al.  Correction of photon attenuation and collimator response for a body-contouring SPECT/CT imaging system. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[77]  D. Berman,et al.  Computed tomography coronary calcium screening and myocardial perfusion imaging , 2005, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[78]  William D Erwin,et al.  The value of 99mTc-sestamibi SPECT/CT over conventional SPECT in the evaluation of parathyroid adenomas or hyperplasia. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[79]  Ora Israel,et al.  Technetium-99m-MIBI SPECT/CT in Primary Hyperparathyroidism , 2005, World Journal of Surgery.

[80]  J. Bouček,et al.  Validation of prospective whole-body bone marrow dosimetry by SPECT/CT multimodality imaging in 131I-anti-CD20 rituximab radioimmunotherapy of non-Hodgkin’s lymphoma , 2005, European Journal of Nuclear Medicine and Molecular Imaging.

[81]  R. Günther,et al.  Sixteen-slice spiral CT versus MR imaging for the assessment of left ventricular function in acute myocardial infarction , 2005, European Radiology.

[82]  H. Amthauer,et al.  Impact of SPECT and integrated low-dose CT after radioiodine therapy on the management of patients with thyroid carcinoma , 2004, Nuclear medicine communications.

[83]  Kurt Schicho,et al.  SPECT-CT for topographic mapping of sentinel lymph nodes prior to gamma probe-guided biopsy in head and neck squamous cell carcinoma. , 2004, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[84]  Mario Petretta,et al.  Estimation of coronary flow reserve by Tc-99m sestamibi imaging in patients with coronary artery disease: Comparison with the results of intracoronary Doppler technique , 2004, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[85]  C. Nanni,et al.  Myocardial SPECT: what do we gain from attenuation correction (and when)? , 2004, The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of....

[86]  C. Claussen,et al.  Evaluation of combined transmission and emission tomography for classification of skeletal lesions. , 2004, AJR. American journal of roentgenology.

[87]  Naoto T Ueno,et al.  Bone imaging in metastatic breast cancer. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[88]  W. Martin,et al.  Impact of 131I-SPECT/CT images obtained with an integrated system in the follow-up of patients with thyroid carcinoma , 2004, European Journal of Nuclear Medicine and Molecular Imaging.

[89]  J. Eary,et al.  High-dose (131)I-tositumomab (anti-CD20) radioimmunotherapy for non-Hodgkin's lymphoma: adjusting radiation absorbed dose to actual organ volumes. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[90]  Cyrill Burger,et al.  CT attenuation correction for myocardial perfusion quantification using a PET/CT hybrid scanner. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[91]  Y. Nishiyama,et al.  Clinical usefulness of fusion of 131I SPECT and CT images in patients with differentiated thyroid carcinoma. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[92]  A. Engel,et al.  SPECT/CT hybrid imaging with 111In‐pentetreotide in assessment of neuroendocrine tumours , 2003, Clinical endocrinology.

[93]  E. Even-Sapir,et al.  Lymphoscintigraphy for sentinel node mapping using a hybrid SPECT/CT system. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[94]  M. Minoves.  Bone and joint sports injuries: the role of bone scintigraphy , 2003, Nuclear medicine communications.

[95]  William C. Barber,et al.  Dual-Modality Imaging of Cancer with SPECT/CT , 2002, Technology in cancer research & treatment.

[96]  Peter Bartenstein,et al.  SPET/CT image co-registration in the abdomen with a simple and cost-effective tool , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[97]  A. Engel,et al.  The new technology of combined transmission and emission tomography in evaluation of endocrine neoplasms. , 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[98]  B H Hasegawa,et al.  Absolute quantification of regional myocardial uptake of 99mTc-sestamibi with SPECT: experimental validation in a porcine model. , 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[99]  K Van Laere,et al.  Automated stereotactic standardization of brain SPECT receptor data using single-photon transmission images. , 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[100]  Michael Wilk,et al.  Gamma camera-mounted anatomical X-ray tomography: technology, system characteristics and first images , 2000, European Journal of Nuclear Medicine.

[101]  O. Simonetti,et al.  Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. , 1999, Circulation.

[102]  B H Hasegawa,et al.  Myocardial perfusion imaging with a combined x-ray CT and SPECT system. , 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[103]  J C Liehn,et al.  Thoracic and abdominal SPECT-CT image fusion without external markers in endocrine carcinomas. The Group of Thyroid Tumoral Pathology of Champagne-Ardenne. , 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[104]  J. Bishop,et al.  Decision logic for retreatment of asymptomatic lung cancer recurrence based on positron emission tomography findings. , 1995, International journal of radiation oncology, biology, physics.

[105]  Robert M. Lewitt,et al.  Fourier correction for spatially variant collimator blurring in SPECT , 1995, IEEE Trans. Medical Imaging.

[106]  Lee-Tzuu Chang,et al.  A Method for Attenuation Correction in Radionuclide Computed Tomography , 1978, IEEE Transactions on Nuclear Science.