Sympathetic Nervous System Dysregulation of Cardiac Function and Myocyte Potassium Channel Remodeling in Rodent Seizure Models: Candidate Mechanisms for SUDEP

[1]  M. Nei,et al.  Sudden Unexpected Death in Epilepsy , 2010, Current neurology and neuroscience reports.

[2]  R. Pandey,et al.  Cardiovascular autonomic functions in well-controlled and intractable partial epilepsies , 2009, Epilepsy Research.

[3]  M. Borggrefe,et al.  Channelopathies: Brugada syndrome, long QT syndrome, short QT syndrome, and CPVT , 2009, Herz Kardiovaskuläre Erkrankungen.

[4]  R. Hrachovy,et al.  Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation , 2009, Epilepsia.

[5]  P. Radwański,et al.  Status epilepticus produces chronic alterations in cardiac sympathovagal balance , 2009, Epilepsia.

[6]  Cheryl C. H. Yang,et al.  Heart rate variability in patients with frontal lobe epilepsy , 2009, Seizure.

[7]  B. Dumotier,et al.  Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts. , 2008, American journal of physiology. Heart and circulatory physiology.

[8]  D. Tompson,et al.  Lamotrigine does not prolong QTc in a thorough QT/QTc study in healthy subjects. , 2008, British journal of clinical pharmacology.

[9]  O. Bakiner,et al.  Subclinical Hypothyroidism Is Characterized by Increased QT Interval Dispersion among Women , 2008, Medical Principles and Practice.

[10]  F. Scorza,et al.  The other side of the coin: Beneficiary effect of omega-3 fatty acids in sudden unexpected death in epilepsy , 2008, Epilepsy & Behavior.

[11]  D. Tester,et al.  Syntrophin mutation associated with long QT syndrome through activation of the nNOS–SCN5A macromolecular complex , 2008, Proceedings of the National Academy of Sciences.

[12]  I. V. van Langen,et al.  A Case of Catecholaminergic Polymorphic Ventricular Tachycardia Caused by Two Calsequestrin 2 Mutations , 2008, Pacing and clinical electrophysiology : PACE.

[13]  F. Scorza,et al.  Preventive measures for sudden cardiac death in epilepsy beyond therapies , 2008, Epilepsy & Behavior.

[14]  S. S. Hull,et al.  Prediction of unexpected sudden death among healthy dogs by a novel marker of autonomic neural activity. , 2008, Heart rhythm.

[15]  M. W. Bungo,et al.  The mystery of sudden death: Mechanisms for risks , 2008, Epilepsy & Behavior.

[16]  J. Dobruch,et al.  Interaction of AT1 receptors and V1a receptors-mediated effects in the central cardiovascular control during the post-infarct state , 2007, Regulatory Peptides.

[17]  A. Biraben,et al.  Current approaches to the use of generic antiepileptic drugs , 2007, Epilepsy & Behavior.

[18]  P. Vestergaard,et al.  Adverse effects of antiepileptic drugs on bone mineral density in children , 2007, Expert opinion on drug safety.

[19]  J. Safdieh,et al.  The safety of levetiracetam , 2007, Expert opinion on drug safety.

[20]  A. Schulze-Bonhage,et al.  The influence of antiepileptic drugs on cognition: A comparison of levetiracetam with topiramate , 2007, Epilepsy & Behavior.

[21]  Josemir W Sander,et al.  Antiepileptic drugs: generic versus branded treatments , 2007, The Lancet Neurology.

[22]  W. Alves,et al.  Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures , 2007, Neurology.

[23]  S. Duncan.  Teratogenesis of sodium valproate , 2007, Current opinion in neurology.

[24]  F. Andermann,et al.  Compulsory Generic Switching of Antiepileptic Drugs: High Switchback Rates to Branded Compounds Compared with Other Drug Classes , 2007, Epilepsia.

[25]  J. Nerbonne,et al.  Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QT , 2007, The Journal of physiology.

[26]  M. Fishbein,et al.  New Perspectives on the Role of Autonomic Nervous System in the Genesis of Arrhythmias , 2007, Journal of cardiovascular electrophysiology.

[27]  J. Mintz,et al.  Exaggerated Cardiovascular Stress Responses and Impaired β-Adrenergic–Mediated Pressor Recovery in Obese Zucker Rats , 2006, Hypertension.

[28]  Hee-Sup Shin,et al.  Thyrotropin‐releasing hormone increases GABA release in rat hippocampus , 2006, The Journal of physiology.

[29]  P. Adamson,et al.  Reducing the Risk of Sudden Death in Heart Failure With β-Blockers , 2006 .

[30]  Michael J Ackerman,et al.  Mutant Caveolin-3 Induces Persistent Late Sodium Current and Is Associated With Long-QT Syndrome , 2006, Circulation.

[31]  P. Satishchandra,et al.  Cardiac autonomic dysfunctions in chronic refractory epilepsy , 2006, Epilepsy Research.

[32]  T. Herold.  Lamotrigine as a possible cause of QRS prolongation in a patient with known seizure disorder. , 2006, CJEM.

[33]  M. Holtmann,et al.  Beeinträchtigen subklinische epileptische Entladungen wirklich das Kurzzeitgedächtnis von Kindern , 2006 .

[34]  P. Schraeder,et al.  Stress and sudden death , 2006, Epilepsy & Behavior.

[35]  C. E. Elger,et al.  Finding the missing link between ictal bradyarrhythmia, ictal asystole, and sudden unexpected death in epilepsy , 2006, Epilepsy & Behavior.

[36]  Tracy Glauser,et al.  ILAE Treatment Guidelines: Evidence‐based Analysis of Antiepileptic Drug Efficacy and Effectiveness as Initial Monotherapy for Epileptic Seizures and Syndromes , 2006, Epilepsia.

[37]  F. Chiarelli,et al.  Bone Metabolism and Vitamin D Levels in Carbamazepine‐treated Patients , 2006, Epilepsia.

[38]  Gregory L. Holmes,et al.  Role of interictal epileptiform abnormalities in cognitive impairment , 2006, Epilepsy & Behavior.

[39]  H. Huikuri,et al.  Cardiac Autonomic Control in Patients with Refractory Epilepsy before and during Vagus Nerve Stimulation Treatment: A One‐Year Follow‐up Study , 2006, Epilepsia.

[40]  Josemir W Sander,et al.  Pregabalin: A new antiepileptic drug for refractory epilepsy , 2006, Seizure.

[41]  E. Perucca.  British Journal of Clinical Pharmacology Clinically Relevant Drug Interactions with Antiepileptic Drugs , 2022 .

[42]  R. Weiss,et al.  The Effects of Chronic Fluoxetine Treatment on Chronic Mild Stress-Induced Cardiovascular Changes and Anhedonia , 2006, Biological Psychiatry.

[43]  I. Leppik,et al.  Hyponatremia from oxcarbazepine and carbamazepine , 2005, Neurology.

[44]  C. Helmstaedter,et al.  EpiTrack: Tracking cognitive side effects of medication on attention and executive functions in patients with epilepsy , 2005, Epilepsy & Behavior.

[45]  A. Aldenkamp,et al.  Behaviour, cognition and epilepsy , 2005, Acta neurologica Scandinavica. Supplementum.

[46]  G. M. Kuz,et al.  Carbamazepine-Induced Hyponatremia: Assessment of Risk Factors , 2005, The Annals of pharmacotherapy.

[47]  G. Tomaselli,et al.  Molecular basis of arrhythmias. , 2005, Circulation.

[48]  P. Dorian.  Antiarrhythmic Action ofβ-Blockers: Potential Mechanisms , 2005 .

[49]  S. Hohnloser.  Ventricular Arrhythmias: Antiadrenergic Therapy for the Patient with Coronary Artery Disease , 2005, Journal of cardiovascular pharmacology and therapeutics.

[50]  G. Krauss,et al.  Improved tolerability and efficacy in epilepsy patients with extended-release carbamazepine , 2005, Neurology.

[51]  Mike R. Schoenberg,et al.  Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteers , 2005, Neurology.

[52]  M. Dam,et al.  Sudden Unexpected Death in Epilepsy: Is Death by Seizures a Cardiac Disease? , 2005, The American journal of forensic medicine and pathology.

[53]  M Sculpher,et al.  Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation. , 2005, Health technology assessment.

[54]  Kelly C. Lear-Kaul,et al.  Sudden Unexpected Death in Epilepsy: A Retrospective Study , 2005, The American journal of forensic medicine and pathology.

[55]  S. McDougall,et al.  Differential gene expression in WKY and SHR brain following acute and chronic air-puff stress. , 2005, Brain research. Molecular brain research.

[56]  B. Uthman,et al.  Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy , 2005, Neurology.

[57]  D. Trenite,et al.  The impact of subclinical epileptiform discharges on complex tasks and cognition: relevance for aircrew and air traffic controllers , 2005, Epilepsy & Behavior.

[58]  J. Dobruch,et al.  Enhanced involvement of brain vasopressin V1 receptors in cardiovascular responses to stress in rats with myocardial infarction , 2005, Stress.

[59]  J. Duncan,et al.  Cardiac arrhythmias in focal epilepsy: a prospective long-term study , 2004, The Lancet.

[60]  M. Feucht,et al.  EKG abnormalities in children and adolescents with symptomatic temporal lobe epilepsy , 2004, Neurology.

[61]  N. Fukuoka.  [Influence of coadministered antiepileptic drugs on serum antiepileptic drug concentrations in epileptic patients -quantitative analysis based on suitable transforming factor]. , 2004, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[62]  Fabio Sebastiano,et al.  Ictal heart rate increase precedes EEG discharge in drug-resistant mesial temporal lobe seizures , 2004, Clinical Neurophysiology.

[63]  Maromi Nei,et al.  EEG and ECG in Sudden Unexplained Death in Epilepsy , 2004, Epilepsia.

[64]  M. Knip,et al.  Thyroid Function in Girls with Epilepsy with Carbamazepine, Oxcarbazepine, or Valproate Monotherapy and after Withdrawal of Medication , 2004, Epilepsia.

[65]  M. Morrell,et al.  Epilepsy and bone health in adults , 2004, Epilepsy & Behavior.

[66]  J. Arends,et al.  The Relative Influence of Epileptic EEG Discharges, Short Nonconvulsive Seizures, and Type of Epilepsy on Cognitive Function , 2004, Epilepsia.

[67]  C. Antzelevitch,et al.  Autonomic aspects of arrhythmogenesis: the enduring and the new , 2004, Current opinion in cardiology.

[68]  N. Fukuoka,et al.  Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor. , 2003, Biological & pharmaceutical bulletin.

[69]  C. Binnie,et al.  Cognitive impairment during epileptiform discharges: is it ever justifiable to treat the EEG? , 2003, The Lancet Neurology.

[70]  S. Berkovic,et al.  Risk factors for sudden unexpected death in epilepsy: a controlled prospective study based on coroners cases , 2003, Seizure.

[71]  C. Elger,et al.  Significant improvement in frontal lobe associated neuropsychological functions after withdrawal of Topiramate in epilepsy patients , 2003, Epilepsy Research.

[72]  H. Claycamp,et al.  Clinical Pharmacology of Topiramate versus Lamotrigine versus Phenobarbital: Comparison of Efficacy and Side Effects Using Odds Ratios , 2003, Journal of clinical pharmacology.

[73]  A. Johnson,et al.  Behavioral and cardiovascular changes in the chronic mild stress model of depression , 2003, Physiology & Behavior.

[74]  F. Dubeau,et al.  The Effects of Adjunctive Topiramate on Cognitive Function in Patients with Epilepsy , 2003, Epilepsia.

[75]  K. Anderson.  Sympathetic Nervous System Activity and Ventricular Tachyarrhythmias: Recent Advances , 2003, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[76]  A. Johnson,et al.  Cardiovascular alterations and autonomic imbalance in an experimental model of depression. , 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

[77]  M. Brodie,et al.  Topiramate in Patients with Learning Disability and Refractory Epilepsy , 2002, Epilepsia.

[78]  P. Schraeder,et al.  Clinical Pharmacology: Drugs as a Benefit and/or Risk in Sudden Unexpected Death in Epilepsy? , 2002, Journal of clinical pharmacology.

[79]  H V Huikuri,et al.  Heart rate dynamics in refractory and well controlled temporal lobe epilepsy , 2002, Journal of neurology, neurosurgery, and psychiatry.

[80]  M Radespiel-Tröger,et al.  Interictal cardiac autonomic dysfunction in temporal lobe epilepsy demonstrated by [(123)I]metaiodobenzylguanidine-SPECT. , 2001, Brain : a journal of neurology.

[81]  A. Aldenkamp.  Cognitive and behavioural assessment in clinical trials: when should they be done? , 2001, Epilepsy Research.

[82]  A J Camm,et al.  Baroreflex Sensitivity and Heart Rate Variability in the Identification of Patients at Risk for Life-Threatening Arrhythmias: Implications for Clinical Trials , 2001, Circulation.

[83]  G. Plosker,et al.  Levetiracetam. A review of its adjunctive use in the management of partial onset seizures. , 2000, Drugs.

[84]  M. Inoue,et al.  Short-term effects of rapid pacing on mRNA level of voltage-dependent K(+) channels in rat atrium: electrical remodeling in paroxysmal atrial tachycardia. , 2000, Circulation.

[85]  D. Ficker.  Sudden Unexplained Death and Injury in Epilepsy , 2000, Epilepsia.

[86]  S. Berkovic,et al.  Comparison of Antiepileptic Drug Levels in Sudden Unexpected Deaths in Epilepsy with Deaths from Other Causes , 1999, Epilepsia.

[87]  E. Mcgugan,et al.  Sudden Unexpected Deaths in Epileptics — A Literature Review , 1999, Scottish medical journal.

[88]  K. Bachmann,et al.  Differential Kinetics of Phenytoin in Elderly Patients , 1999, Drugs & aging.

[89]  S. Schachter.  Antiepileptic Drug Therapy: General Treatment Principles and Application for Special Patient Populations , 1999, Epilepsia.

[90]  K. Airaksinen.  Autonomic mechanisms and sudden death after abrupt coronary occlusion. , 1999, Annals of medicine.

[91]  L. Nilsson,et al.  Risk factors for sudden unexpected death in epilepsy: a case control study , 1999, The Lancet.

[92]  P. Hoff-Olsen,et al.  Sudden death in two patients with epilepsy and the syndrome of inappropriate antidiuretic hormone secretion (siadh) , 1998, Seizure.

[93]  P. Timmings.  Sudden unexpected death in epilepsy: is carbamazepine implicated? , 1998, Seizure.

[94]  T. Tomson,et al.  Postmortem changes in blood concentrations of phenytoin and carbamazepine: an experimental study. , 1998, Therapeutic drug monitoring.

[95]  G G Davis,et al.  Comparison of anti-epileptic drug levels in different cases of sudden death. , 1998, Journal of forensic sciences.

[96]  T. Tomson,et al.  Heart rate variability in patients with epilepsy 1 Presented in part at the 2nd European Congress of Epileptology, The Hague, September, 1996. 1 , 1998, Epilepsy Research.

[97]  P. Schwartz,et al.  Baroreflex Sensitivity as a Cardiac and Arrhythmia Mortality Risk Stratifier , 1997, Pacing and clinical electrophysiology : PACE.

[98]  T. Tomson,et al.  Changes in arrhythmia profile and heart rate variability during abrupt withdrawal of antiepileptic drugs. Implications for sudden death , 1997, Seizure.

[99]  J. Zihl,et al.  Illumination perception in photophobic patients suffering from panic disorder with agoraphobia , 1997, Acta psychiatrica Scandinavica.

[100]  Rungroj Krittayaphong,et al.  Heart Rate Variability in Patients with Coronary Artery Disease: Differences in Patients with Higher and Lower Depression Scores , 1997, Psychosomatic medicine.

[101]  Paul Schraeder,et al.  Sudden Unexplained Death in Epilepsy: Observations from a Large Clinical Development Program , 1997, Epilepsia.

[102]  J. Cai,et al.  Association of cardiac autonomic function and the development of hypertension: the ARIC study. , 1996, American journal of hypertension.

[103]  T. May,et al.  Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication. , 1996, Therapeutic drug monitoring.

[104]  T. Hasegawa,et al.  The necessity of adjusting the dosage of zonisamide when coadministered with other anti-epileptic drugs. , 1996, Biological & pharmaceutical bulletin.

[105]  G. Breithardt,et al.  Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. , 1996 .

[106]  P. Schraeder,et al.  Clinical Pharmacology of Antiepileptic Drug Use: “Clinical Pearls about the Perils of Patty” , 1995, Journal of clinical pharmacology.

[107]  F. Besag.  The therapeutic dilemma: treating subtle seizures or indulging in electroencephalogram cosmetics? , 1995, Seminars in pediatric neurology.

[108]  J. Annegers,et al.  Cohort Study of Incidence of Sudden Unexplained Death in Persons with Seizure Disorder Treated with Antiepileptic Drugs in Saskatchewan, Canada , 1995, Epilepsia.

[109]  K. Meador.  Cognitive Side Effects of Antiepileptic Drugs , 1994, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[110]  Josemir W Sander,et al.  Newer Antiepileptic Drugs , 1994, Drug safety.

[111]  P. Stein,et al.  Heart rate variability: a measure of cardiac autonomic tone. , 1994, American heart journal.

[112]  Orrin Devinsky,et al.  Interictal Autonomic Nervous System Function in Patients with Epilepsy , 1994, Epilepsia.

[113]  M. Duchowny,et al.  Carbamazepine toxicity resulting from generic substitution , 1993, Neurology.

[114]  P. Timmings,et al.  Sudden unexpected death in epilepsy: a local audit , 1993, Seizure.

[115]  P. Schraeder,et al.  The Effect of Phenobarbital on Autonomic Function and Epileptogenic Activity Induced by the Hippocampal Injection of Penicillin in Cats , 1993, Journal of clinical pharmacology.

[116]  H. V. van Geijn,et al.  Heart Rate Variability , 1993, Annals of Internal Medicine.

[117]  A. Pakarinen,et al.  Thyroid Function with Antiepileptic Drugs , 1992, Epilepsia.

[118]  R. Dasheiff,et al.  Sudden unexpected death in epilepsy: a series from an epilepsy surgery program and speculation on the relationship to sudden cardiac death. , 1991, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[119]  R. Ramsay,et al.  Carbamazepine Metabolism in Humans: Effect of Concurrent Anticonvulsant Therapy , 1990, Therapeutic drug monitoring.

[120]  R. Levin,et al.  The Effect of Dilevalol on Cardiac Autonomic Neural Discharge, Plasma Catecholamines, and Myocardial Beta Receptor Density Associated with Coronary Occlusion , 1990, Journal of clinical pharmacology.

[121]  C. Lathers,et al.  The relationship of the lock-step phenomenon and precipitous changes in mean arterial blood pressure. , 1989, Electroencephalography and clinical neurophysiology.

[122]  P. Schraeder,et al.  Paroxysmal autonomie dysfunction, epileptogenic activity and sudden death , 1989, Epilepsy Research.

[123]  C. Lathers,et al.  Does Chlorpromazine Produce Cardiac Arrhythmia Via the Central Nervous System? , 1988, Journal of clinical pharmacology.

[124]  R. Levin,et al.  The Effect of Chronic Timolol in an Animal Model for Myocardial Infarction , 1988, Journal of clinical pharmacology.

[125]  C. D. Binnie,et al.  Psychological effects of subclinical epileptiform EEG discharges. I. Scholastic skills , 1988, Epilepsy Research.

[126]  P. Schraeder,et al.  Synchronization of cardiac autonomic neural discharge with epileptogenic activity: the lockstep phenomenon. , 1987, Electroencephalography and clinical neurophysiology.

[127]  P. Schraeder,et al.  Review of Autonomic Dysfunction, Cardiac Arrhythmias, and Epileptogenic Activity , 1987, Journal of clinical pharmacology.

[128]  C. Lathers,et al.  Psychoactive Agents, Seizure Production, and Sudden Death in Epilepsy , 1987, Journal of clinical pharmacology.

[129]  J. Miller,et al.  Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. , 1987, The American journal of cardiology.

[130]  C. Lathers,et al.  Cardiac Arrhythmia, Sudden Death, and Psychoactive Agents , 1987, Journal of clinical pharmacology.

[131]  R. Levin,et al.  The effect of acute and chronic administration of timolol on cardiac sympathetic neural discharge, arrhythmia, and beta adrenergic receptor density associated with coronary occlusion in the cat. , 1986, Life sciences.

[132]  R. Levin,et al.  Regional distribution of myocardial β-adrenoceptors in the cat , 1986 .

[133]  C. Lathers,et al.  The Effect of C1 Spinal Cord Transection or Bilateral Adrenal Vein Ligation on Thioridazine‐Induced Arrhythmia and Death in the Cat , 1986, Journal of clinical pharmacology.

[134]  C. Lathers,et al.  Chlorpromazine: cardiac arrhythmogenicity in the cat. , 1986, Life sciences.

[135]  H. Gormsen,et al.  The role of antiepileptics in sudden death in epilepsy , 1985, Acta neurologica Scandinavica.

[136]  M. Aminoff,et al.  Changes in plasma catecholamines after tonic‐clonic seizures , 1984, Neurology.

[137]  P. Schraeder,et al.  Cardiac neural discharge and epileptogenic activity in the cat: an animal model for unexplained death. , 1983, Life sciences.

[138]  P. Schraeder,et al.  Autonomic Dysfunction in Epilepsy: Characterization of Autonomic Cardiac Neural Discharge Associated with Pentylenetetrazol‐Induced Epileptogenic Activity , 1982, Epilepsia.

[139]  G. Celesia,et al.  The effects of epileptogenic activity on auditory evoked potentials in cats. , 1977, Archives of neurology.

[140]  Anne Sabers,et al.  Effect of Antiepileptic Drugs on Cognitive Function in Individuals with Epilepsy , 2012, Drugs.

[141]  T. Takano,et al.  Neurogenic stunned myocardium associated with status epileptics and postictal catecholamine surge. , 2008, Internal medicine.

[142]  R. Levy,et al.  Risk and predictability of drug interactions in the elderly. , 2007, International review of neurobiology.

[143]  Y. Kamijo,et al.  Intermittent complete atrioventricular block after long term low-dose carbamazepine therapy with a serum concentration less than the therapeutic level. , 2007, Internal medicine.

[144]  T. Tomson,et al.  Pharmacokinetic Variability of Newer Antiepileptic Drugs , 2006, Clinical pharmacokinetics.

[145]  D. Figgitt,et al.  Pregabalin , 2005, CNS drugs.

[146]  C. Davies,et al.  Inhibition of α1E Ca2+ Channels by Carbonic Anhydrase Inhibitors , 2004 .

[147]  G. Holmes,et al.  Prescribing Antiepileptic Drugs , 2004, CNS drugs.

[148]  N. Fukuoka,et al.  Effects of concomitant antiepileptic drugs on serum carbamazepine concentration in epileptic patients: quantitative analysis based on extracellular water volume as a transforming factor. , 2003, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[149]  L. Stephen.  Drug Treatment of Epilepsy in Elderly People , 2003, Drugs & aging.

[150]  D. Dunn,et al.  Progressive behavioral changes in children with epilepsy. , 2002, Progress in brain research.

[151]  P. Stein,et al.  Insights from the study of heart rate variability. , 1999, Annual review of medicine.

[152]  R. Campbell.  Predisposing Factors for Ventricular Arrhythmias , 1991, Journal of cardiovascular pharmacology.