In vivo multiphoton fluorescence imaging: A novel approach to oral malignancy

Current techniques for oral diagnosis require surgical biopsy of lesions, and may fail to detect early malignant change. Non‐invasive, sensitive tools providing early detection of oral cancer and a better understanding of malignant change are needed. These studies evaluated in vivo multiphoton excited fluorescence (MPM) techniques to (1) map epithelial and subepithelial changes through out oral carcinogenesis and (2) serve as an effective diagnostic modality.

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