production in subacute sclerosing panencephalitis

DivisionofChildNeurology, Institute of Neurological Sciences, Tottori University, Yonago, Tottori, JapanLive measles virus-specific T helper 1/T helper 2-cytokine productions byperipheral blood mononuclear cells in response to live measles, mumps orvaricella virus were measured in 15 patients with subacute sclerosingpanencephalitis and 15 controls by enzyme-linked immunosorbent assays.Mostpatientswithsubacutesclerosingpanencephalitis hadadefect in measlesvirus-specific production of interferon-g, one of the T helper 1 type cytokines,despite persistent presence of measles virus, with preserved interleukin-10 (Thelper 2 type cytokine) synthesis. Patients with subacute sclerosing panence-phalitis were divided into two groups: responders (group A) with significantinterferon-gproduction(420 pg/mL)inresponsetolivemeaslesvirusandnon-responders (group B) with a little or no interferon-gproduction. Comparison ofthe clinical courses between groups A and B revealed that all the patients ofgroupAretainedreceptivefunctionforalongtime,whilemostpatientsofgroupBlostthefunctionrapidly(P50.01).Aninversecorrelationbetweeninterferon-g production by peripheral blood mononuclear cells and disease progressionsuggested that interferon-g plays an antiviral role in subacute sclerosingpanencephalitis.Journal of NeuroVirology(2000) 6, 121–126.Keywords: interferon-g; interleukin-2; interleukin-10; prognosis

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