Dual-task performance in Alzheimer's disease, mild cognitive impairment, and normal ageing.

Although several studies have shown that dual-tasking ability is impaired in Alzheimer's disease (AD), the stage at which this deficit manifests remains unclear. This study investigated if a new paper-and-pencil assessment of dual-tasking ability could distinguish between AD, mild cognitive impairment (MCI) and normal ageing in a sample of 50 people with AD, 49 people with MCI, and 50 healthy age-matched controls. The AD group demonstrated a significant impairment in dual-task ability. There was no effect of either MCI or healthy ageing on dual-task performance, indicating that the dual-task impairment is specific to AD.

[1]  Alan D Baddeley,et al.  Is there a specific executive capacity for dual task coordination? Evidence from Alzheimer's disease. , 2004, Neuropsychology.

[2]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[3]  A. Baddeley,et al.  The Quarterly Journal of Experimental Psychology Section a Human Experimental Psychology Dementia and Working Memory Dementia and Working Memory , 2022 .

[4]  Maria Victoria Sebastian,et al.  Attentional Dysfunction of the Central Executive in Ad: Evidence from Dual Task and Perseveration Errors , 2006, Cortex.

[5]  E. Olsson,et al.  Effect of Divided Attention on Gait in Subjects With and Without Cognitive Impairment , 2007, Journal of geriatric psychiatry and neurology.

[6]  A. Wallin,et al.  The Goteborg MCI study: mild cognitive impairment is a heterogeneous condition , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[7]  F. Craik,et al.  Divided attention in younger and older adults: effects of strategy and relatedness on memory performance and secondary task costs. , 2005, Journal of experimental psychology. Learning, memory, and cognition.

[8]  A. Baddeley,et al.  Autobiographical memory and executive function in early dementia of Alzheimer type , 1995, Neuropsychologia.

[9]  A. Baddeley,et al.  Attentional control in Alzheimer's disease. , 2001, Brain : a journal of neurology.

[10]  E. Tangalos,et al.  Mild Cognitive Impairment Clinical Characterization and Outcome , 1999 .

[11]  L H Kuller,et al.  Neuropsychological characteristics of mild cognitive impairment subgroups , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[12]  Sarah E. MacPherson,et al.  Specific AD Impairment in Concurrent Performance of Two Memory Tasks , 2007, Cortex.

[13]  J. Touchon,et al.  Classification criteria for mild cognitive impairment , 2001, Neurology.

[14]  A. Baddeley,et al.  Working Memory and Vigilance: Evidence from Normal Aging and Alzheimer's Disease , 1999, Brain and Cognition.

[15]  J. Hodges,et al.  The nature and staging of attention dysfunction in early (minimal and mild) Alzheimer’s disease: relationship to episodic and semantic memory impairment , 2000, Neuropsychologia.

[16]  T. Salthouse,et al.  Aging of attention: Does the ability to divide decline? , 1995, Memory & cognition.

[17]  Sarah E. MacPherson,et al.  Dual-Task Interference on Encoding and Retrieval Processes in Healthy and Impaired Working Memory , 2004, Cortex.

[18]  J. Hodges,et al.  Perception, attention, and working memory are disproportionately impaired in dementia with Lewy bodies compared with Alzheimer's disease , 2001, Journal of neurology, neurosurgery, and psychiatry.

[19]  Roee Holtzer,et al.  The sensitivity of dual-task performance to cognitive status in aging , 2004, Journal of the International Neuropsychological Society.

[20]  S. Rose,et al.  Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging , 2000, Journal of neurology, neurosurgery, and psychiatry.

[21]  A. Baddeley.  Working Memory, Thought, and Action , 2007 .

[22]  H. Feldman,et al.  Potential for misclassification of mild cognitive impairment: A study of memory scores on the Wechsler Memory Scale-III in healthy older adults , 2008, Journal of the International Neuropsychological Society.

[23]  Steven DeKosky,et al.  Early Intervention Is Key to Successful Management of Alzheimer Disease , 2003, Alzheimer disease and associated disorders.

[24]  A D Baddeley,et al.  The decline of working memory in Alzheimer's disease. A longitudinal study. , 1991, Brain : a journal of neurology.

[25]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease: Report of the NINCDS—ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease , 2011, Neurology.

[26]  T. Salthouse,et al.  Division of attention: Age differences on a visually presented memory task , 1984, Memory & cognition.

[27]  Robert H. Logie,et al.  Alzheimer’s disease, but not ageing or depression, affects dual-tasking , 2009, Journal of Neurology.

[28]  A. Baddeley,et al.  Dual‐Task Paradigm: A Means To Examine the Central Executive , 1995, Annals of the New York Academy of Sciences.

[29]  D. Selkoe.  Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.

[30]  Zuzana Walker,et al.  The functional anatomy of divided attention in amnestic mild cognitive impairment. , 2005, Brain : a journal of neurology.

[31]  S. Belleville,et al.  Effect of normal aging on the manipulation of information in working memory , 1998, Memory & cognition.

[32]  The Other Side of Normal , 2007, Journal of the International Neuropsychological Society.

[33]  T. Tasdizen,et al.  Realizing the potential of positron emission tomography with 18F-fluorodeoxyglucose to improve the treatment of Alzheimer’s disease , 2008, Alzheimer's & Dementia.

[34]  Costanza Papagno,et al.  Testing central executive functioning with a pencil and paper test , 1997 .

[35]  B. Dubois,et al.  Apathy in patients with mild cognitive impairment and the risk of developing dementia of Alzheimer's disease A one-year follow-up study , 2006, Clinical Neurology and Neurosurgery.

[36]  L. Berg.  Clinical Dementia Rating (CDR). , 1988, Psychopharmacology bulletin.

[37]  A. Baddeley,et al.  Primary and working memory functioning in Alzheimer-type dementia. , 1988, Journal of clinical and experimental neuropsychology.

[38]  Sarah E. MacPherson,et al.  Dual Task Demands On Encoding And Retrieval Processes: Evidence From Healthy Adult Ageing , 2007, Cortex.

[39]  R. Morris,et al.  Short-term forgetting in senile dementia of the Alzheimer's type , 1986 .

[40]  R H Logie,et al.  Dual task effects of walking when talking in Alzheimer's disease. , 2004, Revue neurologique.

[41]  C. Bell.  Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision: DSM-IV-TR Quick Reference to the Diagnostic Criteria from DSM-IV-TR , 2001 .