Relationship Between Changes in Left Ventricular Dimensions and the Ejection Fraction in Man

Left ventricular length and calculated diameter were derived from angiocardiograms in 24 subjects with various heart diseases. Chamber diameter was noted to decrease an average of 27.5% from end-diastole to end-systole, and chamber length decreased 13%. Only subjects with calculations of left ventricular mass differing less than 25% from end-diastole to end-systole were accepted in order to avoid effects of spurious increases in end-systolic wall thickness on calculated diameter. Patients with localized disorders of contraction were also excluded. An extremely close linear relationship between the percentage change in diameter and the ejection fraction was demonstrated. Analysis of the radii of curvature showed that the lateral wall usually straightens during systole. However, if extreme ventricular dilatation is present, the lateral-wall curvature increases with systole. The possible implications of this alteration in contraction pattern and its effect upon the ejection fraction were discussed.

[1]  W. C. Elliott,et al.  LEFT VENTRICULAR VOLUME IN MAN MEASURED BY THERMODILUTION. , 1964, The Journal of clinical investigation.

[2]  H. Dodge,et al.  The use of biplane angiocardigraphy for the measurement of left ventricular volume in man. , 1960, American heart journal.

[3]  R. Steiner,et al.  THE CARDIAC IMPULSE AND THE MOTION OF THE HEART , 1964, British heart journal.

[4]  E H Wood,et al.  Volume, ejection fraction, and internal dimensions of left ventricle determined by biplane videometry. , 1969, Federation proceedings.

[5]  J. Criley,et al.  Pressure Gradients without Obstruction: A New Concept of “Hypertrophic Subaortic Stenosis” , 1965, Circulation.

[6]  H. Dodge,et al.  Left ventricular mass , 1967 .

[7]  D. Ghista,et al.  Mechanical and dynamic implications of dimensional measurements of the left ventricle. , 1969, Federation proceedings.

[8]  Edward W. Hawthorne,et al.  Dynamic geometry of the left ventricle , 1966 .

[9]  C Grant,et al.  Estimation of Left Ventricular Volume by One‐Plane Cineangiography , 1967, Circulation.

[10]  H. Westcott Vayo,et al.  A Hemodynamic Study of Left Ventricular Aneurysm , 1967, Circulation.

[11]  R. Brawley,et al.  Can outflow obstruction be induced within the normal left ventricle? , 1965, The American journal of cardiology.

[12]  R. F. Rushmer,et al.  The Functional Anatomy of Ventricular Contraction , 1953, Circulation research.

[13]  I G McDonald,et al.  The shape and movements of the human left ventricle during systole. A study by cineangiography and by cineradiography of epicardial markers. , 1970, The American journal of cardiology.

[14]  H. Feigenbaum,et al.  Correlation of ultrasound with angiocardiography in measuring left ventricular diastolic volume , 1969 .

[15]  P G Hugenholtz,et al.  Application of fiberoptic dye-dilution technic to the assessment of myocardial function. I. Description of technic and results in 100 patients with congenital or acquired heart disease. , 1969, The American journal of cardiology.

[16]  A cineangiocardiographic study of the regional contraction sequence of the normal and diseased left ventricle in man. , 1969, Japanese heart journal.

[17]  H. Dodge,et al.  Quantitation of valvular insufficiency in man by angiocardiography. , 1963, American heart journal.

[18]  Robert I. White,et al.  Experimental production of intracavity pressure differences. Possible significance in the interpretation of human hemodynamic studies. , 1967, The American journal of cardiology.

[19]  P G Hugenholtz,et al.  Determination of left ventricular wall thickness by angiocardiography. , 1969, American heart journal.

[20]  E. Sallin.  Fiber orientation and ejection fraction in the human left ventricle. , 1969, Biophysical journal.

[21]  K Wildenthal,et al.  Geometrical studies of the left ventricle utilizing biplane cinefluorography. , 1969, Federation proceedings.

[22]  H Sandler,et al.  Dimensional analysis of the heart--a review. , 1970, The American journal of the medical sciences.

[23]  J. Bristow,et al.  LEFT VENTRICULAR VOLUME MEASUREMENTS IN MAN BY THERMODILUTION. , 1964, The Journal of clinical investigation.

[24]  J Ross,et al.  Contractile State of the Left Ventricle in Man: Instantaneous Tension‐Velocity‐Length Relations in Patients With And Without Disease of the Left Ventricular Myocardium , 1968, Circulation research.

[25]  J. W. Kennedy,et al.  Measurement of left ventricular volumes in man by single-plane cineangiocardiography. , 1969, Investigative radiology.

[26]  M. Sanmarco,et al.  An analysis of the fit of mathematical models applicable to the measurement of left ventricular volume. , 1966, The American journal of cardiology.

[27]  Kass Is,et al.  Measurement of left ventricular volumes in man by single-plane cineangiocardiography. , 1969, Investigative radiology.

[28]  H J Hermann,et al.  Left ventricular volumes by angiocardiography: comparison of methods and simplification of techniques. , 1968, Cardiovascular research.

[29]  L. Horwitz,et al.  Left ventricular transverse internal diameter: value in studying left ventricular function. , 1970, American heart journal.

[30]  E W HAWTHORNE,et al.  Instantaneous Dimensional Changes of the Left Ventricle in Dogs , 1961, Circulation research.

[31]  H. Dodge,et al.  Left Ventricular Chamber Volume, Mass, and Function in Severe Coronary Artery Disease , 1970, Circulation.

[32]  R. F. Rushmer,et al.  The Mechanics of Ventricular Contraction: A Cinefluorographic Study , 1951, Circulation.

[33]  E. Sonnenblick,et al.  THE ULTRASTRUCTURAL BASIS OF STARLING'S LAW OF THE HEART. THE ROLE OF THE SARCOMERE IN DETERMINING VENTRICULAR SIZE AND STROKE VOLUME. , 1964, American heart journal.

[34]  J. W. Kennedy,et al.  Left ventricular volume and mass from single-plane cineangiocardiogram. A comparison of anteroposterior and right anterior oblique methods. , 1970, American heart journal.

[35]  C Grant,et al.  Left ventricular wall stress calculated from one-plane cineangiography. , 1970, Circulation research.

[36]  H. Dodge,et al.  A Method for Determining Left Ventricular Mass in Man , 1964, Circulation.

[37]  H Sandler,et al.  Usefulness and limitations of radiographic methods for determining left ventricular volume. , 1966, The American journal of cardiology.

[38]  Rolandfolse,et al.  Determination of Fraction of Left Ventricular Volume Ejected per Beat and of Ventricular End-Diastolic and Residual Volumes , 1962 .

[39]  A. H. Khan,et al.  Primary myocardial disease. Clinical, hemodynamic and angiocardiographic correlates in fifty patients. , 1970, The American journal of cardiology.

[40]  R A Heinle,et al.  Localized disorders in myocardial contraction. Asynergy and its role in congestive heart failure. , 1967, The New England journal of medicine.

[41]  H. Swan,et al.  Myocardial Function and Left Ventricular Volumes in Acquired Valvular Insufficiency , 1965, Circulation.