Association of high-sensitivity cardiac troponin T with mortality and cardiovascular events in a community-based prospective study in Beijing

Objective The prognostic value of cardiac troponins in apparently healthy populations is not well established. The aim of this study was to investigate the prognostic properties of high-sensitivity cardiac troponin T (hs-cTnT) for long-term adverse outcomes. Setting A community-dwelling prospective survey of residents from two communities in Beijing. Participants From September 2007 to January 2009, 1680 participants were initially enrolled. Of these, 1499 (870 females, mean age: 61.4 years) participants completed the survey and were followed up for a median of 4.8 years (IQR: 4.5–5.2). Outcome measures The primary outcome was the occurrence of all-cause mortality and major cardiovascular

[1]  A. Sharrett,et al.  Determinants of minimal elevation in high-sensitivity cardiac troponin T in the general population. , 2016, Clinical biochemistry.

[2]  P. Serruys,et al.  High-sensitivity Troponin T in relation to coronary plaque characteristics in patients with stable coronary artery disease; results of the ATHEROREMO-IVUS study. , 2016, Atherosclerosis.

[3]  G. Hillis,et al.  Cardiac Troponin and its Relationship to Cardiovascular Outcomes in Community Populations - A Systematic Review and Meta-analysis. , 2016, Heart, lung & circulation.

[4]  D. Siscovick,et al.  Serial measurement of N-terminal pro-B-type natriuretic peptide and cardiac troponin T for cardiovascular disease risk assessment in the Multi-Ethnic Study of Atherosclerosis (MESA). , 2015, American heart journal.

[5]  N. Sotoodehnia,et al.  Serial measures of cardiac troponin T levels by a highly sensitive assay and incident atrial fibrillation in a prospective cohort of ambulatory older adults. , 2015, Heart rhythm.

[6]  A. Dominiczak,et al.  Biomarkers of cardiomyocyte injury and stress identify left atrial and left ventricular remodelling and dysfunction: A population-based study. , 2015, International journal of cardiology.

[7]  P. Stein,et al.  Cardiomyocyte injury assessed by a highly sensitive troponin assay and sudden cardiac death in the community: the Cardiovascular Health Study. , 2013, Journal of the American College of Cardiology.

[8]  J. D. de Lemos,et al.  Prevalence and significance of detectable troponins as measured by highly sensitive assays in the general population , 2013, Coronary artery disease.

[9]  P. Collinson,et al.  The Association Between Cortisol Response to Mental Stress and High-Sensitivity Cardiac Troponin T Plasma Concentration in Healthy Adults , 2013, Journal of the American College of Cardiology.

[10]  W. März,et al.  High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide predict mortality in stable coronary artery disease: results from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study , 2013, Clinical chemistry and laboratory medicine.

[11]  T. Kawasaki,et al.  Usefulness of high-sensitivity cardiac troponin T and brain natriuretic peptide as biomarkers of myocardial fibrosis in patients with hypertrophic cardiomyopathy. , 2013, The American journal of cardiology.

[12]  A. Siegbahn,et al.  High-sensitive cardiac troponin T and its relations to cardiovascular risk factors, morbidity, and mortality in elderly men. , 2013, American heart journal.

[13]  Mary G. George,et al.  An Updated Definition of Stroke for the 21st Century: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association , 2013, Stroke.

[14]  M. Whooley,et al.  High-sensitivity cardiac troponin T levels and secondary events in outpatients with coronary heart disease from the Heart and Soul Study. , 2013, JAMA internal medicine.

[15]  A. Folsom,et al.  Troponin T, N-Terminal Pro–B-Type Natriuretic Peptide, and Incidence of Stroke: The Atherosclerosis Risk in Communities Study , 2013, Stroke.

[16]  F. Forastiere,et al.  High‐sensitivity cardiac troponin T for detection of subtle abnormalities of cardiac phenotype in a general population of elderly individuals , 2013, Journal of internal medicine.

[17]  L. V. Van Pelt,et al.  High-sensitive troponin T and N-terminal pro-B type natriuretic peptide are associated with cardiovascular events despite the cross-sectional association with albuminuria and glomerular filtration rate. , 2012, European heart journal.

[18]  L. Tavazzi,et al.  Serial Measurement of Cardiac Troponin T Using a Highly Sensitive Assay in Patients With Chronic Heart Failure: Data From 2 Large Randomized Clinical Trials , 2012, Circulation.

[19]  T. Edvardsen,et al.  Prognostic usefulness of circulating high-sensitivity troponin T in aortic stenosis and relation to echocardiographic indexes of cardiac function and anatomy. , 2011, The American journal of cardiology.

[20]  J. Cigarroa,et al.  Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study. , 2011, Journal of the American College of Cardiology.

[21]  H. White.  Pathobiology of troponin elevations: do elevations occur with myocardial ischemia as well as necrosis? , 2011, Journal of the American College of Cardiology.

[22]  Eric Boerwinkle,et al.  Cardiac Troponin T Measured by a Highly Sensitive Assay Predicts Coronary Heart Disease, Heart Failure, and Mortality in the Atherosclerosis Risk in Communities Study , 2011, Circulation.

[23]  A. Khera,et al.  Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. , 2010, JAMA.

[24]  M. Zhan,et al.  Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults. , 2010, JAMA.

[25]  Mario Plebani,et al.  Recommendations for the use of cardiac troponin measurement in acute cardiac care. , 2010, European heart journal.

[26]  Olli Saarela,et al.  Contribution of 30 Biomarkers to 10-Year Cardiovascular Risk Estimation in 2 Population Cohorts: The MONICA, Risk, Genetics, Archiving, and Monograph (MORGAM) Biomarker Project , 2010, Circulation.

[27]  A. Jaffe,et al.  Analytical validation of a high-sensitivity cardiac troponin T assay. , 2010, Clinical chemistry.

[28]  U. Siebert,et al.  Prognostic value, clinical effectiveness, and cost-effectiveness of high-sensitivity C-reactive protein as a marker for major cardiac events in asymptomatic individuals: A health technology assessment report , 2010, International Journal of Technology Assessment in Health Care.

[29]  M. Pencina,et al.  Novel and conventional biomarkers for prediction of incident cardiovascular events in the community. , 2009, JAMA.

[30]  D. Mozaffarian,et al.  Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2009, Circulation.

[31]  D. Mozaffarian,et al.  Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2009, Circulation.

[32]  E. Barrett-Connor,et al.  Minimally elevated cardiac troponin T and elevated N-terminal pro-B-type natriuretic peptide predict mortality in older adults: results from the Rancho Bernardo Study. , 2008, Journal of the American College of Cardiology.

[33]  Anders Larsson,et al.  Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. , 2008, The New England journal of medicine.

[34]  Song-min Huang,et al.  Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. , 2006, Journal of the American Society of Nephrology : JASN.

[35]  Qi-dong Yang,et al.  Incidence of Cerebral Hemorrhage in the Changsha Community , 2004, Cerebrovascular Diseases.

[36]  Eric J Topol,et al.  Prevalence of conventional risk factors in patients with coronary heart disease. , 2003, JAMA.

[37]  Neil R. Powe,et al.  The Atherosclerosis Risk in Communities Study , 2006 .

[38]  H. Tunstall-Pedoe,et al.  Definitions for Acute Coronary Heart Disease in Epidemiology and Clinical Research Studies , 2003 .