Design and development of controlled release intravaginal veterinary drug delivery systems

Publisher Summary The inception of intravaginal veterinary drug delivery dates back to the early 1960s when polyurethane sponges were investigated as a means to deliver synthetic progestagens to sheep and goats. In the 1990s, microchip technology was investigated as a means of delivering multiple drugs at different times and rates for the precise control of estrous synchrony and fertility. All the current intravaginal drug delivery systems used in animals have inherent pharmaceutical problems such as high residual drug loads. These limitations have not appeared to have affected their acceptability with the end-user. This chapter reviews the avenues of research taken by these innovative scientists with animal or plastic engineering backgrounds. The purpose of this chapter is to critically review the literature in order to glean the available information relating to the design and development of intravaginal veterinary drug delivery systems. This information provides the basis upon which to design and assess future intravaginal veterinary drug delivery systems.

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