Sickle β‐thalassemia: Identical twins differing in severity implicate nongenetic factors influencing course

25‐yr old female identical twins of Italian‐American origin concordant for sickle β‐thalassemia were studied to explain their clinical differences. One of them has been severely affected from childhood with one aplastic crisis, an earlier onset of vaso‐occlusive crises, and recent cardiac decompensation; the other twin shows no cardiac decompensation.

[1]  G. Stamatoyannopoulos,et al.  Globin synthesis in fractionated Normoblasts of beta-thalassemia heterozygotes. , 1975, The Journal of clinical investigation.

[2]  J. Young,et al.  The relationships between arterial oxygen flow rate, oxygen binding by hemoglobin, and oxygen utilization after myocardial infarction. , 1974, The Journal of clinical investigation.

[3]  P. Gillette,et al.  Hemolysis in sickle cell disease. , 1974, Archives of internal medicine.

[4]  E. Evans,et al.  New membrane concept applied to the analysis of fluid shear- and micropipette-deformed red blood cells. , 1973, Biophysical journal.

[5]  H. Bakwin.  Body‐weight Regulation in Twins , 1973, Developmental medicine and child neurology.

[6]  M. Farace,et al.  Changes in globin synthesis with erythroid cell maturation in sickle thalassemia. , 1973, Blood.

[7]  F. Gill,et al.  Synthesis of globin chains in sickle -thalassemia. , 1973, The Journal of clinical investigation.

[8]  P. Milner,et al.  The Clinical Features of Sickle‐Cell/β Thalassaemia in Jamaica , 1973, British journal of haematology.

[9]  P. Rowley,et al.  High resolution analysis of hemoglobins: polyacrylamide isoelectric focusing. , 1972, Biochemical medicine.

[10]  Lacelle Pl.  Alteration of membrane deformability in hemolytic anemias. , 1970 .

[11]  S. L. Wolfson,et al.  Transfusion-reversible functional asplenia in young children with sickle-cell anemia. , 1970, The New England journal of medicine.

[12]  H. Pearson.  HEMOGLOBIN S‐THALASSEMIA SYNDROME IN NEGRO CHILDREN 1 , 1969, Annals of the New York Academy of Sciences.

[13]  L. Diamond.  The concept of functional asplenia. , 1969, The New England journal of medicine.

[14]  R. P. Spencer,et al.  Functional asplenia in sickle-cell anemia. , 1969, The New England journal of medicine.

[15]  P. L. Celle.  Alteration of Deformability of the Erythrocyte Membrane in Stored Blood , 1969 .

[16]  E. Merrill,et al.  Metabolic dependence of red cell deformability. , 1969, The Journal of clinical investigation.

[17]  A. Bank,et al.  Intracellular Loss of Free α Chains in β Thalassaemia , 1969, Nature.

[18]  S. Pontremoli,et al.  The Correlation between Red‐Cell Survival and Excess of α‐Globin Synthesis in β‐Thalassaemia , 1969 .

[19]  W. Muir,et al.  Influence of splenectomy on insoluble hemoglobin inclusion bodies in beta thalassemic erythrocytes. , 1968, Blood.

[20]  S. Pontremoli,et al.  Excess of α‐Globin Synthesis in Homozygous β‐Thalassemia and its Removal from the Red Blood Cell Cytoplasm , 1968 .

[21]  E. Huehns,et al.  Haemoglobin Synthesis in β‐Thalassaemia , 1969, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[22]  R. Gunn,et al.  Thalassemia: the consequences of unbalanced hemoglobin synthesis. , 1966, The American journal of medicine.

[23]  J. Clegg,et al.  Abnormal human haemoglobins , 1966 .

[24]  S. Schwartz,et al.  The S‐Thalassemia Syndrome * , 1964, Annals of the New York Academy of Sciences.

[25]  D. Weatherall.  Biochemical Phenotypes of Thalassemia in the American Negro Population * , 1964, Annals of the New York Academy of Sciences.

[26]  S. Boyer,et al.  MODULATION OF PROTEIN SYNTHESIS IN MAN: AN IN VITRO STUDY OF HEMOGLOBIN SYNTHESIS BY HETEROZYGOTES. , 1964, Cold Spring Harbor symposia on quantitative biology.

[27]  J. Lingrel,et al.  A Comparison of Amino Acid Incorporation into the Hemoglobin and Ribosomes of Marrow Erythroid Cells and Circulating Reticulocytes of Severely Anemic Rabbits , 1963 .

[28]  C. Conley,et al.  Hereditary persistence of fetal hemoglobin. A family study. , 1960, The American journal of medicine.

[29]  L. Penrose,et al.  MONOZYGOTIC AND DIZYGOTIC TWIN DIAGNOSIS , 1955, Annals of human genetics.