We experienced a case of carcinosarcoma that is rare in the esophageal cancers. A 69-year-old man was admitted to the hospital because of dysphagia. X-ray examination showed a 2.3cm of indented wall adjacent to a 3.5×7.0cm well-demarcated oval shadow in the middle intrathoracic esophagus. Endoscopic findings revealed an irregular ulceration adjacent to a well-surfaced polyp. Subtotal esophagectomy was carried out. On histopathological examination, the ulcerative area was moderately differentiated squamous cell carcinoma and the polyp was sarcomatous change. Metastatic lymph nodes were not tissues of sarcomatous change but squamous cell carcinoma. The transitional area between the two elements was not recognized histopathologically. Silver staining of the sarcomatous element did not show any epithelial pattern. Immunohistochemical staining was negative for keratins and EMA, and was positive for vimentin and α1-ACT. These findings strongly supported that this case was of pseudosarcoma.
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