Association between polymorphisms of heat-shock protein 70 genes and noise-induced hearing loss: A meta-analysis

Background Recent studies have evaluated the associations between polymorphisms of the heat-shock protein 70 (HSP70) encoding genes and noise-induced hearing loss (NIHL). However, the conclusions of these studies are conflicting. The objective of this meta-analysis was to clarify the association between all known polymorphisms of HSP70 genetic loci and susceptibility to NIHL, based on existing reports. Methods We conducted a meta-analysis of the association between Hsp70 polymorphisms (rs1043618, rs1061581, rs2075800, rs2227956, and rs2763979) and NIHL risk in both Chinese and Caucasian males. All statistical analysis was done with was conducted using the “meta” package (version 4.6–0) of R version 3.3.2 and RStudio version 1.0.44. Online databases were searched for eligible case-control studies on February 13, 2017. The odds ratio (OR), 95% confidence interval (CI), and P value were calculated using Mantel-Haenszel statistics under a random- or fixed-effect model. Results A total of five studies, reported via four articles from online databases, were included in our meta-analysis. For rs1061581 (from three studies), a significant association was detected in the allele model, homozygote model, and dominant model (G versus A: OR (95% CI) = 1.32(1.05–1.67), GG versus AA: OR (95% CI) = 1.93(1.1–3.36), GG + AG versus AA: OR (95% CI) = 1.45(1.05–2.02)), but not in the heterozygote model or the recessive model. For rs1043618 (from five studies), rs2075800 (from two studies), rs2227956 (from four studies), rs2763979 (from two studies), no significant association was found for any genetic model. After subgroup analyses by ethnicity, significant associations were observed for the allele model, heterozygote model, and dominant model for rs1061581 and any genetic model for rs2227956 in Caucasians. Conclusions The rs1043618, rs2075800, and rs2763979 polymorphisms were not found to be associated with susceptibility to NIHL; however, the rs1061581 and rs2227956 polymorphisms were significantly associated with NIHL in Caucasian males.

[1]  P. Luo,et al.  Association of polymorphisms in heat shock protein 70 genes with the susceptibility to noise-induced hearing loss: A meta-analysis , 2017, PloS one.

[2]  H. Hoffman,et al.  Vital Signs: Noise-Induced Hearing Loss Among Adults — United States 2011–2012 , 2017, MMWR. Morbidity and mortality weekly report.

[3]  Hui Wu,et al.  Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study , 2017, PloS one.

[4]  Jochen Schacht,et al.  Emerging therapeutic interventions against noise-induced hearing loss , 2017, Expert opinion on investigational drugs.

[5]  W. Ma,et al.  [Association between CDH23 gene polymorphisms and susceptibility to noise-induced hearing loss in the Chinese population: a meta-analysis]. , 2016, Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.

[6]  M. Hoffer,et al.  The Genomic Basis of Noise-induced Hearing Loss: A Literature Review Organized by Cellular Pathways , 2016, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[7]  Jun Li,et al.  Association of the C47T polymorphism in superoxide dismutase gene 2 with noise-induced hearing loss: a meta-analysis , 2016, Brazilian journal of otorhinolaryngology.

[8]  D. Cotanche,et al.  Genetic Polymorphisms Associated with Hearing Threshold Shift in Subjects during First Encounter with Occupational Impulse Noise , 2015, PloS one.

[9]  E. Eskin,et al.  Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss , 2015, PLoS genetics.

[10]  D. Bing,et al.  17-DMAG induces Hsp70 and protects the auditory hair cells from kanamycin ototoxicity in vitro , 2015, Neuroscience Letters.

[11]  Ran Wang,et al.  [Association of GSTM1 and GSTT1 polymorphisms with noise-induced hearing loss: a meta-analysis]. , 2014, Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.

[12]  S. Tans,et al.  Chaperone action at the single-molecule level. , 2014, Chemical reviews.

[13]  H. Saibil.  Chaperone machines for protein folding, unfolding and disaggregation , 2013, Nature Reviews Molecular Cell Biology.

[14]  S. Roy,et al.  Inner ear supporting cells protect hair cells by secreting HSP70. , 2013, The Journal of clinical investigation.

[15]  L. Hickson,et al.  Noise-induced hearing loss in Asia , 2011, International journal of audiology.

[16]  K. Ho,et al.  Association of Polymorphisms of Heat Shock Protein 70 with Susceptibility to Noise-Induced Hearing Loss in the Taiwanese Population , 2010, Audiology and Neurotology.

[17]  A. Trinidad,et al.  Heat shock protein 70 and cellular disturbances in cochlear cisplatin ototoxicity model , 2010, The Journal of Laryngology & Otology.

[18]  B. Mazurek,et al.  Geldanamycin induces production of heat shock protein 70 and partially attenuates ototoxicity caused by gentamicin in the organ of Corti explants , 2009, Journal of Biomedical Science.

[19]  A. Lusis,et al.  Genome-wide screening for genetic loci associated with noise-induced hearing loss , 2009, Mammalian Genome.

[20]  Julian Little,et al.  Systematic Reviews of Genetic Association Studies , 2009, PLoS medicine.

[21]  J. Huyghe,et al.  Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations , 2009, European Journal of Human Genetics.

[22]  F. Lee,et al.  Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death , 2009, Cell Stress and Chaperones.

[23]  M. Sone,et al.  Upregulation of HSP by geranylgeranylacetone protects the cochlear lateral wall from endotoxin-induced inflammation , 2005, Hearing Research.

[24]  Ammarin Thakkinstian,et al.  A method for meta‐analysis of molecular association studies , 2005, Statistics in medicine.

[25]  John P A Ioannidis,et al.  Heterogeneity testing in meta‐analysis of genome searches , 2005, Genetic epidemiology.

[26]  D. Altman,et al.  Measuring inconsistency in meta-analyses , 2003, BMJ : British Medical Journal.

[27]  S. Thompson,et al.  Quantifying heterogeneity in a meta‐analysis , 2002, Statistics in medicine.

[28]  D J Schaid,et al.  Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions. , 1999, American journal of epidemiology.

[29]  G. Smith,et al.  Bias in meta-analysis detected by a simple, graphical test , 1997, BMJ.

[30]  A. Thompson,et al.  Detection and localization of heat shock protein 70 in the normal guinea pig cochlea , 1991, Hearing Research.

[31]  P. Tugwell,et al.  The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses , 2014 .

[32]  M. Śliwińska-Kowalska,et al.  Contribution of genetic factors to noise-induced hearing loss: a human studies review. , 2013, Mutation research.

[33]  D. Moher,et al.  Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. , 2010, International journal of surgery.

[34]  Q. Wei,et al.  Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers , 2006, Cell stress & chaperones.